Gene therapy and correction can be used in almost all diseases and pathological conditions because of recent advancements, but some questions still have yet to be answered in this field of advancement. Based on the requirements and compatibility, gene therapy is divided into two parts: somatic gene therapy and germline gene therapy. If the transfer of DNA segments is done to cells that will affect the next generation, this is called somatic gene therapy. Somatic gene therapy is currently more efficient in research due to its less ethical issue and less complexity. The toughest task for curing diabetes with gene therapy is to have glucose responsiveness to insulin transgene expression. So studies were carried out to decrease obesity by gene therapy to decrease type 2 diabetes prevalence. Gene therapy using viral vectors remains risky and is still under scrutiny to ensure safety and efficacy during clinical trials.
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