Lifeboat Foundation

What a challenge COVID-19 has had on our global supply chains, exposing vulnerabilities in production capacity, shipping logistics and in particular last mile enablements. According to a recent report of Technavio, the last mile delivery market will grow to USD $14.96B from 2021 to 2025, with a CAGR of 15.06%. Also according to tier one market research firm, Gartner Group, by 2023, 50% of leading global enterprises will have invested in real-time transportation visibility solutions.

Last mile delivery is defined as the transportation of goods and services from a distribution hub to the final customer destination, within a reasonable time at an affordable rate and in mint condition. Supply chain focus on the last mile has significantly become top of mind given the COVID-19 global pandemic, as organizations have had to refresh/rethink their conveyance systems and develop new creative strategies to build more proficient conveyance intelligence.

In times of unprecedented challenges, especially in the past two years, companies are accelerating their investments in robotics, trade channel expansion, laser precision targeted product and supply chains, and last mile intelligence systems.

Up to 90% of patients who undergo open abdominal or pelvic surgery develop postoperative adhesions, or scar tissue. Minimally invasive laparoscopic surgical approaches can reduce the severity of the adhesions, but the scar tissue still forms. The cellular response to injury—even intentional injury, such as surgery to repair a problem—results in a cascade of molecules pouring to the site to heal the tissue. But the molecules, working quickly to close the wound, often go too far and bind the wound to nearby healthy tissue. Depending on the location, the resulting scar tissue can cause chronic pain, bowel obstruction and even death.

There may be a potential solution available soon, according to researchers from Southern Medical University in China. They have developed an injectable hydrogel that can plug up wounds without sticking to off target tissue, effectively preventing postoperative adhesions.

Their approach, tested in rats and rabbits, was published on Nov. 18 in Advanced Functional Materials.

Sediments in which archaeological finds are embedded have long been regarded by most archaeologists as unimportant by-products of excavations. However, in recent years it has been shown that sediments can contain ancient biomolecules, including DNA. “The retrieval of ancient human and faunal DNA from sediments offers exciting new opportunities to investigate the geographical and temporal distribution of ancient humans and other organisms at sites where their skeletal remains are rare or absent,” says Matthias Meyer, senior author of the study and researcher at the Max Planck Institute for Evolutionary Anthropology in Leipzig.

To investigate the origin of DNA in the sediment, Max Planck researchers teamed up with an international group of geoarchaeologists—archaeologists who apply geological techniques to reconstruct the formation of sediment and sites—to study DNA preservation in sediment at a microscopic scale. They used undisturbed blocks of sediment that had been previously removed from archaeological sites and soaked in synthetic plastic-like (polyester) resin. The hardened blocks were taken to the laboratory and sliced in sections for microscopic imaging and genetic analysis.

The researchers successfully extracted DNA from a collection of blocks of sediment prepared as long as 40 years ago, from sites in Africa, Asia, Europe and North America. “The fact that these blocks are an excellent source of ancient DNA—including that originating from hominins—despite often decades of storage in plastic, provides access to a vast untapped repository of genetic information. The study opens up a new era of ancient DNA studies that will revisit samples stored in labs, allowing for analysis of sites that have long since been back-filled, which is especially important given travel restriction and site inaccessibility in a pandemic world,” says Mike Morley from Flinders University in Australia who led some of the geoarchaeological analyses.

The COVID-19 pandemic highlighted the devastating impact of acute lung inflammation (ALI), which is part of the acute respiratory distress syndrome (ARDS) that is the dominant cause of death in COVID-19. A potential new route to the diagnosis and treatment of ARDS comes from studying how neutrophils—the white blood cells responsible for detecting and eliminating harmful particles in the body—differentiate what materials to uptake by the material’s surface structure, and favor uptake of particles that exhibit “protein clumping,” according to new research from the Perelman School of Medicine at the University of Pennsylvania. The findings are published in Nature Nanotechnology.

Researchers investigated how neutrophils are able to differentiate between bacteria to be destroyed and other compounds in the bloodstream, such as cholesterol particles. They tested a library consisting of 23 different protein-based nanoparticles in mice with ALI which revealed a set of “rules” that predict uptake by neutrophils. Neutrophils don’t take up symmetrical, rigid particles, such as viruses, but they do take up particles that exhibited “protein clumping,” which the researchers call nanoparticles with agglutinated protein (NAPs).

“We want to utilize the existing function of neutrophils that identifies and eliminates invaders to inform how to design a ‘Trojan horse’ nanoparticle that overactive neutrophils will intake and deliver treatment to alleviate ALI and ARDS,” said study lead author Jacob Myerson, Ph.D., a postdoctoral research fellow in the Department of Systems Pharmacology and Translational Therapeutics. “In order to build this ‘Trojan horse’ delivery system, though, we had to determine how neutrophils identify which particles in the blood to take up.”

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Undoubtedly the fear of death, encoded in our DNA to improve our chances of survival, is one of the least pleasant characteristics we are forced to live with. The idea that our life must have an end and then there is nothingness is not at all attractive, so it is not surprising that in the course of his history man has imagined countless ways to circumvent death.
Immortality (or eternal life) is the concept of surviving forever or for an indefinite period of time, without facing death or overcoming death itself.

Immortality can be intended in two main meanings, physical and spiritual. Physical immortality is generally conceived as the endless existence of the mind from a physical source, such as a brain or a computer. Spiritual immortality is generally conceived as the endless existence of an individual after physical death.

Continue reading “The Future Technology To Become Immortal” »

A small box glowing with a brilliant blue light has saved the lives of numerous babies since its inception, and it’s only getting started.

This innovative box is called Crib A’Glow, and it’s a low-cost phototherapy solution for treating newborn babies with neonatal jaundice, a condition in which a baby’s skin and the whites of the eyes appear yellow due to excess bilirubin. When untreated, this ailment, which is extremely common as newborns haven’t developed the liver function to properly process the bilirubin, can cause hearing loss, blindness, brain damage, and even death, which is why instant treatment is recommended. This is where the novel phototherapy unit comes in.

Crib A’Glow was developed by Virtue Oboro 0, a mother and graphic designer from Nigeria, after her son’s experience with jaundice. Shortly after giving birth in 2015, Oboro noticed the classic yellow hue commonly associated with the disease in her son, and right after, he was diagnosed with jaundice. However, due to a lack of available phototherapy units in the hospital, his health deteriorated to the point that a blood transfusion was needed immediately. Her son survived the incident; however, Oboro was a changed woman after that.

When technology allows you to do things by just thinking, it provides a massive boost to people whose functional independence has been taken away.

A magnetic field can be used to switch nanolasers on and off, shows new research from Aalto University. The physics underlying this discovery paves the way for the development of optical signals that cannot be disturbed by external disruptions, leading to unprecedented robustness in signal processing.

Lasers concentrate light into extremely bright beams that are useful in a variety of domains, such as broadband communication and medical diagnostics devices. About ten years ago, extremely small and fast lasers known as plasmonic nanolasers were developed. These nanolasers are potentially more power-efficient than traditional lasers, and they have been of great advantage in many fields—for example, nanolasers have increased the sensitivity of biosensors used in medical diagnostics.

So far, switching nanolasers on and off has required manipulating them directly, either mechanically or with the use of heat or light. Now, researchers have found a way to remotely control nanolasers.

A major new study of ancient DNA has traced the movement of people into southern Britain during the Bronze Age. In the largest such analysis published to date, scientists examined the DNA of nearly 800 ancient individuals.

The new study, led by the University of York, Harvard Medical School, and the University of Vienna, shows that people moving into southern Britain around 1300‒800 BC were responsible for around half the genetic ancestry of subsequent populations.

The combined DNA and archaeological evidence suggests that, rather than a violent invasion or a single migratory event, the genetic structure of the population changed through sustained contacts between mainland Britain and Europe over several centuries, such as the movement of traders, intermarriage, and small scale movements of family groups.