which envisions coordinating hundreds of #robots for missions in urban areas. http://ow.ly/OtWm50H8by5
Researchers have refined a molecule that shows promise for the prevention of Parkinson’s disease.
Researchers have refined a molecule that shows promise for the prevention of Parkinson’s disease.… See more.
Summary: Researchers have refined a molecule that shows promise for the prevention of Parkinson’s disease.
Source: University of Bath
Continue reading “Are Scientists Homing in on a Cure for Parkinson’s Disease?” »
Experimental compound, which has received orphan drug and pediatric rare disease designations from the FDA, displays effectiveness in treating symptoms of Autism and Alzheimer’s disease. Researchers developed a novel model to assess the effect of this experimental drug on symptoms related to au.
After DeepMind’s breakthrough in protein folding last year, Alphabet will double down on artificial intelligence in biology and health with its new venture.
A newly approved eye drop hitting the market on Thursday could change the lives of millions of Americans with age-related blurred near vision, a condition affecting mostly people 40 and older.
Vuity, which was approved by the Food and Drug Administration in October, would potentially replace reading glasses for some of the 128 million Americans who have trouble seeing close-up. The new medicine takes effect in about 15 minutes, with one drop on each eye providing sharper vision for six to 10 hours, according to the company.
Toni Wright, one of the 750 participants in a clinical trial to test the drug, said she liked what she saw.
The brain is considered a very expensive organ to run.
Your brain may be leaking … energy, according to a new study that may explain why your noggin consumes 20% of the energy needed to keep your body running.
The study researchers found that tiny sacs called vesicles that hold messages being transmitted between brain cells may be constantly oozing energy, and that leakage is likely a trade-off for the brain being ready to fire at all times, according to a new study published Dec. 3 in the journal Science Advances.
These longstanding challenges are both related to how functionals behave when presented with a system that exhibits “fractional electron character.” By using a neural network to represent the functional and tailoring our training dataset to capture the fractional electron behaviour expected for the exact functional, we found that we could solve the problems of delocalization and spin symmetry-breaking. Our functional also showed itself to be highly accurate on broad, large-scale benchmarks, suggesting that this data-driven approach can capture aspects of the exact functional that have thus far been elusive.
For years, computer simulations have played a central role in modern engineering, making it possible to provide reliable answers to questions like “will this bridge stay up?” to “will this rocket make it into space?” As technology increasingly turns to the quantum scale to explore questions about materials, medicines, and catalysts, including those we’ve never seen or even imagined, deep learning shows promise to accurately simulate matter at this quantum mechanical level.
Researchers in China have developed a new three-pronged method to fight liver cancer that shows promise in tests in mice. The technique combines drugs and CRISPR-Cas9 gene editing into lipid nanoparticles, then activates them with ultrasound.
One emerging treatment against cancer is known as sonodynamic therapy (SDT), which involves delivering drugs to the tumor and then activating them with ultrasound pulses. That produces reactive oxygen species (ROS) that can induce oxidative stress on the cancer cells to kill them. Unfortunately, cancer can counter this attack with antioxidant enzymes, reducing the method’s efficiency.
So for the new study, the researchers investigated a way to remove that defense system. The team suspected that they could use CRISPR to switch off a gene called NFE2L2, which cancer cells use to set off their antioxidant defenses. The team packaged both the CRISPR machinery and the ROS-producing drugs into lipid nanoparticles, which could be activated with ultrasound pulses.
Many intractable diseases are the result of a genetic mutation. Genome editing technology promises to correct the mutation and thus new treatments for patients. However, getting the technology to the cells that need the correction remains a major challenge. A new study led by CiRA Junior Associate Professor Akitsu Hotta and in collaboration with Takeda Pharmaceutical Company Limited as part of the T-CiRA Joint Research Program reports how lipid nanoparticles provide an effective means for the delivery to treat Duchenne muscular dystrophy (DMD) in mice.
Last year’s Nobel Prize for Chemistry to the discoverers of CRISPR-Cas9 cemented the impact of genome editing technology. While CRISPR-Cas9 can be applied to agriculture and livestock for more nutritious food and robust crops, most media attention is on its medical potential. DMD is just one of the many diseases that researchers foresee a treatment using CRISPR-Cas9.
“Oligonucleotide drugs are now available for DMD, but their effects are transient, so the patient has to undergo weekly treatments. On the other hand, CRISPR-Cas9 effects are long lasting,” said Hotta.
Gene therapy is a powerful developing technology that has the potential to address myriad diseases. For example, Huntington’s disease, a neurodegenerative disorder, is caused by a mutation in a single gene, and if researchers could go into specific cells and correct that defect, theoretically those cells could regain normal function.
A major challenge, however, has been creating the right “delivery vehicles” that can carry genes and molecules into the cells that need treatment, while avoiding the cells that do not.
Now, a team led by Caltech researchers has developed a gene-delivery system that can specifically target brain cells while avoiding the liver. This is important because a gene therapy intended to treat a disorder in the brain, for example, could also have the side effect of creating a toxic immune response in the liver, hence the desire to find delivery vehicles that only go to their intended target. The findings were shown in both mouse and marmoset models, an important step towards translating the technology into humans.
