Lifeboat Foundation

On Wednesday, he published an essay on the worldwide effort to end poverty by 2030, and he says that he’s very much a believer that it can be done.

“There is good reason for optimism about progress on reducing inequity,” he writes. He published the essay from Davos, Switzerland, where the World Economic Forum is taking place this week.

Gates points out that since the turn of the century, “Maternal deaths have almost halved; child mortality and malaria deaths have halved; extreme poverty has more than halved.” Plus, thanks to the Global Fund, a project supported by the Gates Foundation, 17 million lives have been saved from malaria, AIDS, and tuberculosis.

The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe the sequencing, assembly, and annotation of the Tasmanian devil genome and whole-genome sequences for two geographically distant subclones of the cancer. Genomic analysis suggests that the cancer first arose from a female Tasmanian devil and that the clone has subsequently genetically diverged during its spread across Tasmania. The devil cancer genome contains more than 17,000 somatic base substitution mutations and bears the imprint of a distinct mutational process. Genotyping of somatic mutations in 104 geographically and temporally distributed Tasmanian devil tumors reveals the pattern of evolution and spread of this parasitic clonal lineage, with evidence of a selective sweep in one geographical area and persistence of parallel lineages in other populations.

Circa 2013

In a feat of “molecular time travel,” the researchers resurrected and analyzed the functions of the ancestors of genes that play key roles in modern human reproduction, development, immunity and cancer. By re-creating the same DNA changes that occurred during those genes’ ancient history, the team showed that two mutations set the stage for hormones like estrogen, testosterone and cortisol to take on their crucial present-day roles.

“Changes in just two letters of the genetic code in our deep evolutionary past caused a massive shift in the function of one protein and set in motion the evolution of our present-day hormonal and reproductive systems,” said Joe Thornton, PhD, professor of human genetics and ecology & evolution at the University of Chicago, who led the study.

“If those two mutations had not happened, our bodies today would have to use different mechanisms to regulate pregnancy, libido, the response to stress, kidney function, inflammation, and the development of male and female characteristics at puberty,” Thornton said.

Circa 2011 essentially cancer could help with evolution as it can challenge the immune system to be more strong. Essentially a symbiotic relationship to evolve with it and grow stronger with it then like it can be used as a good thing to make sure that evolution has stronger genetic code.

Evolutionary theories are critical for understanding cancer development at the level of species as well as at the level of cells and tissues, and for developing effective therapies. Animals have evolved potent tumor suppressive mechanisms to prevent cancer development. These mechanisms were initially necessary for the evolution of multi-cellular organisms, and became even more important as animals evolved large bodies and long lives. Indeed, the development and architecture of our tissues were evolutionarily constrained by the need to limit cancer. Cancer development within an individual is also an evolutionary process, which in many respects mirrors species evolution. Species evolve by mutation and selection acting on individuals in a population; tumors evolve by mutation and selection acting on cells in a tissue. The processes of mutation and selection are integral to the evolution of cancer at every step of multistage carcinogenesis, from tumor genesis to metastasis. Factors associated with cancer development, such as aging and carcinogens, have been shown to promote cancer evolution by impacting both mutation and selection processes. While there are therapies that can decimate a cancer cell population, unfortunately, cancers can also evolve resistance to these therapies, leading to the resurgence of treatment-refractory disease. Understanding cancer from an evolutionary perspective can allow us to appreciate better why cancers predominantly occur in the elderly, and why other conditions, from radiation exposure to smoking, are associated with increased cancers. Importantly, the application of evolutionary theory to cancer should engender new treatment strategies that could better control this dreaded disease.

We expect that the public generally views evolutionary biology as a science about the past, with stodgy old professors examining dusty fossils in poorly lit museum basements. Evolution must certainly be a field well-separated from modern medicine and biomedical research, right? If the public makes a connection between evolution and medicine, it is typically in the example of bacteria acquiring antibiotic resistance. But what does evolution have to do with afflictions like heart disease, obesity, and cancer? As it turns out, these diseases are intricately tied to our evolutionary histories, and understanding evolution is essential for preventing, managing and treating these diseases (1, 2). This review will focus on cancer: how evolutionary theories can be used to understand cancer development at the level of species as well as at the level of cells and tissues. We will also discuss the implications and benefits of an evolutionary perspective towards cancer prevention and therapies.

Continue reading “How cancer shapes evolution, and how evolution shapes cancer” »

Proteins function by folding into myriad, precise 3D structures. Image: Mohammed AlQuraishi.

It’s a city of 11 million.

Drug companies are trying to find new ways to discover new blockbuster drug treatments faster, and AI is beginning to answer the call.

If robots are to help out in places like hospitals and phone repair shops, they’re going to need a light touch. And what’s lighter than not touching at all? Researchers have created a gripper that uses ultrasonics to suspend an object in midair, potentially making it suitable for the most delicate tasks.

It’s done with an array of tiny speakers that emit sound at very carefully controlled frequencies and volumes. These produce a sort of standing pressure wave that can hold an object up or, if the pressure is coming from multiple directions, hold it in place or move it around.

This kind of “acoustic levitation,” as it’s called, is not exactly new — we see it being used as a trick here and there, but so far there have been no obvious practical applications. Marcel Schuck and his team at ETH Zürich, however, show that a portable such device could easily find a place in processes where tiny objects must be very lightly held.

Two studies find strong predictive power of microbiome in complex diseases and death.