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“Fahy’s fascination with the thymus goes back to 1986, when he read a study in which scientists transplanted growth-hormone-secreting cells into rats, apparently rejuvenating their immune systems,” Nature reported. “He was surprised that no one seemed to have followed up on the result with a clinical trial. A decade later, at age 46, he treated himself for a month with growth hormone and DHEA, and found some regeneration of his own thymus.”

The thymus is located in the chest between the lungs and the breastbone and is crucial for efficient immune function. “White blood cells are produced in bone marrow and then mature inside the thymus, where they become specialized T-cells that help the body to fight infections and cancers,” Nature reported. “But the gland starts to shrink after puberty and increasingly becomes clogged with fat. Evidence from animal and some human studies shows that growth hormone stimulates regeneration of the thymus. But this hormone can also promote diabetes, so the trial included two widely used anti-diabetic drugs, dehydroepiandrosterone (DHEA) and metformin, in the treatment cocktail.”

Continue reading “Cocktail Of Drugs Gives First Hope That ‘Biological Age’ Can Be Reversed” »

All living beings are made up of cells. Some of them are made up of only one cell and others have many cells. The average adult human body has around 37.2 trillion cells. WOW, that’s a lot of cells. So many, in fact, that it’s hard to picture. But let’s try to imagine it: If we lined up all the cells in a human body end to end, could the line reach around the Earth? If so, how many times?

Heart problems are more likely for people taller than 5ft 7 inches, a new study suggests, with the risk increasing with every inch.

Scientists in the US found that height is linked to an increased chance of developing atrial fibrillation, an irregular and often rapid heartbeat that can lead to stroke and heart failure.

Researchers studied more than 600,000 people involved in the Penn Medicine Biobank, of whom 65,446 (12.5 per cent) had atrial fibrillation.

Beyond cortical and limbic systems, the company Neuralink could add a third layer of digital superintelligence to humans and avoid artificial intelligence enslavement, its founder Elon Musk claimed Tuesday. The brain-computer linkup firm is working to treat medical conditions using its implanted chip as early as next year, but during a podcast appearance, Musk reiterated his belief that the technology could avoid some of the worst consequences of advanced machines.

https://www.youtube.com/watch?v=smK9dgdTl40

“It’s important that Neuralink solves this problem sooner rather than later, because the point at which we have digital superintelligence, that’s when we pass the singularity and things become just very uncertain,” Musk said during an interview with MIT professor Lex Fridman.

Continue reading “Elon Musk says Neuralink could bring A.I. ‘superintelligence’ to the brain” »

An international team based in Austria has unearthed a previously unknown type of virus in samples of human bodily fluids. The researchers were looking for viruses that infect bacteria, known as bacteriophages, with an emphasis on those that attack the Escherichia coli (E. coli) bacterium found in the human gut. The team identified a total of 43 bacteriophages in samples of human bodily fluids, particularly in blood samples. The discovery of such phages in the human body is especially significant because they can pass antibiotic resistance genes on to bacteria. Consequently, information about the prevalence and frequency of phages in humans, as well as the relationships between them, is urgently needed. The findings of a team from Karl Landsteiner University of Health Sciences under the lead of University of Veterinary Medicine Vienna, which have now been published in an international journal, will make a major contribution in this regard.

The human body is teeming with countless fungi, bacteria and viruses. Bacteriophages are one of the great unknowns in this human ecosystem. Interest in them has grown rapidly in light of research carried out in Austria, which highlighted the prevalence of antibiotic resistance genes in bacteria. A team of researchers from Karl Landsteiner University of Health Sciences (KL Krems), the University of Veterinary Medicine Vienna and the University of Lisbon has now isolated 43 bacteriophages from samples of human bodily fluids, including one which is thought to be a previously unknown type.

“We examined 111 samples of blood, urine and other human body fluids to see if they contained phages. And we found them in almost one in seven samples,” explained Dr. Cátia Pacífico, scientist at KL Krems and lead author of the study. “We also found a new kind of phage from the Tunavirinae subfamily. The presence of phages in so many samples and the discovery of a new form show just how little we know about phages in the human body.”

New research from the University of Adelaide suggests living great apes are smarter than our pre-human ancestor Australopithecus, a group that included the famous “Lucy.”

The study, conducted in partnership with the Evolutionary Studies Institute of the University of the Witwatersrand and published today in the Proceedings of the Royal Society B, challenges the long-held idea that, because the brain of Australopithecus was larger than that of many modern apes, it was smarter.

The new research measured the rate of blood flow to the cognitive part of the brain, based on the size of the holes in the skull that passed the supply arteries. This technique was calibrated in humans and other mammals and applied to 96 great ape skulls and 11 Australopithecus fossil skulls.

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The 65-year-old is the first paralyzed American to finish a marathon.

Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians—meaning people over the age of 110—have an excess of a type of immune cell called cytotoxic CD4 T-cells.

Supercentenarians are a unique group of people. First, they are extremely rare. For example, in Japan in 2015 there were more than 61,000 people over the age of 100, but just 146 over the age of 110. And studies have found that these individuals were relatively immune to illnesses such as infections and cancer during their whole lifetimes. This led to the idea that it might be that they have a particularly strong immune system, and the researchers set out to find out what might explain this.

To answer the question, they looked at circulating immune cells from a group of supercentenarians and younger controls. They acquired a total of 41,208 cells from seven supercentenarians (an average of 5,887 per subject) and 19,994 cells for controls (an average of 3,999 per subject) from five controls aged in their fifties to eighties. They found that while the number of B-cells was lower in the supercentenarians, the number of T-cells was approximately the same, and in particular, the number of one subset of T-cells was increased in the supercentenarians. Analyzing these cells, the authors found that the supercentenarians had a very high level of cells that are cytotoxic, meaning that they can kill other cells, sometimes amounting to 80 percent of all T-cells, compared to just 10 or 20 percent in the controls.