Lifeboat Foundation

A flamingo lives 40 years and a human being lives 90 years; a mouse lives two years and an elephant lives 60. Why? What determines the lifespan of a species? After analyzing nine species of mammals and birds, researchers at the Spanish National Cancer Research Center (CNIO) found a very clear relationship between the lifespan of these species and the shortening rate of their telomeres, the structures that protect the chromosomes and the genes they contain. The relationship is expressed as a mathematical equation, a formula that can accurately predict the longevity of the species. The study was done in collaboration with the Madrid Zoo Aquarium and the University of Barcelona.

“The telomere shortening rate is a powerful predictor of species lifespan,” the authors write in the prestigious journal Proceedings of the National Academy of Sciences (PNAS).

The study compares the telomeres of mice, goats, dolphins, gulls, reindeer, vultures, flamingos, elephants and humans, and reveals that species whose telomeres shorten faster have shorter lives.

(KINSHASA, Congo) — Doctors in Congo say that two Ebola patients who were treated with new anti-Ebola drugs in Goma in eastern Congo have been declared “cured.”

Doctors fighting Ebola quickly used the case on Tuesday to press the message that people with Ebola can recover if they seek proper care.

An international team of subsurface explorers from the University of Adelaide in Australia and the University of Aberdeen in Scotland have uncovered a previously undescribed ‘Jurassic World’ of around 100 ancient volcanoes buried deep within the Cooper-Eromanga Basins of central Australia.

The Cooper-Eromanga Basins in the north-eastern corner of South Australia and south-western corner of Queensland is Australia’s largest onshore oil and gas producing region of Australia. But, despite about 60 years of petroleum exploration and production, this ancient Jurassic volcanic underground landscape has gone largely unnoticed.

Published in the journal Gondwana Research, the researchers used advanced subsurface imaging techniques, analogous to medical CT scanning, to identify the plethora of volcanic craters and lava flows, and the deeper magma chambers that fed them. They’ve called the volcanic region the Warnie Volcanic Province, with a nod to Australian cricket legend Shane Warne.

Last September, an American traveling in Kenya suffered a serious stroke, and was hospitalized there for a month. The stay didn’t go well: The person suffered a bout of pneumonia, a urinary tract infection, and a brush with sepsis, a life-threatening immune reaction to infection.

Maryn McKenna (@marynmck) is an Ideas contributor for WIRED, a senior fellow at the Schuster Institute for Investigative Journalism at Brandeis University, and the author of Big Chicken.

Eventually the traveler’s condition stabilized enough to be brought home, to the intensive care unit of a hospital in Maryland. Because they had been in that foreign hospital for so long, the US institution decided to be extra careful. It put the patient (who hasn’t been named publicly, to respect medical privacy) into an isolation room and required that everyone on the treatment team wear a gown and gloves. After consulting the state health department, the hospital also decided to check the patient for any superbugs that might have been picked up overseas.

Thin, flexible fibers made of carbon nanotubes have now proven able to bridge damaged heart tissues and deliver the electrical signals needed to keep those hearts beating.

Scientists at Texas Heart Institute (THI) report they have used those biocompatible fibers in studies that showed sewing them directly into damaged tissue can restore electrical function to hearts.

“Instead of shocking and defibrillating, we are actually correcting diseased conduction of the largest major pumping chamber of the heart by creating a bridge to bypass and conduct over a scarred area of a damaged heart,” said Dr. Mehdi Razavi, a cardiologist and director of Electrophysiology Clinical Research and Innovations at THI, who co-led the study with Rice chemical and biomolecular engineer Matteo Pasquali.

Animal models provide benefits for biomedical research, but translating such findings to human physiology can be difficult. The human heart’s energy needs and functions are difficult to reproduce in other animals, such as mice and rats. One new system looks to circumvent these issues and provide a functional view of how different treatments can help ailing cells in the heart following oxygen and nutrient deprivations.

Researchers have unveiled a new silicon chip that holds human lab-grown heart muscle cells for assessing the effectiveness of new drugs. The system includes heart cells, called cardiomyocytes, patterned on the chip with electrodes that can both stimulate and measure electrical activity within the cells. The researchers discuss their work in this week’s APL Bioengineering.

These capabilities provide a way for determining how the restriction of blood supply, a dangerous state known as ischemia, changes a heart’s conduction velocity, beat frequency and important electrical intervals associated with heart function.

Today, we want to highlight an interview with billionaire investor Jim Mellon that our friend, Adam Ford of Science, Technology, and the Future, has conducted. Like us, Adam was at the Undoing Aging conference in Berlin earlier this year, and, just as we were, he was busy conducting a number of interviews with the researchers and industry thought leaders there.

Jim Mellon is an interesting figure in the industry and the cofounder of Juvenescence, a company that has been investing in a number of promising companies that are developing rejuvenation biotechnology to treat age-related diseases.

Continue reading “Adam Ford Talks With Jim Mellon of Juvenescence” »

With the rise of fad diets, “superfoods,” and a growing range of dietary supplement choices, it’s sometimes hard to know what to eat.

This can be particularly relevant as we grow older and are trying to make the best choices to minimize the risk of health problems such as high blood pressure, obesity, type 2 diabetes, and heart (cardiovascular) problems.

We now have evidence these health problems also all affect brain function: they increase nerve degeneration in the brain, leading to a higher risk of Alzheimer’s disease and other brain conditions including vascular dementia and Parkinson’s disease.

Amid unrelenting chaos and violence, scientists and doctors in the Democratic Republic of Congo have been running a clinical trial of new drugs to try to combat a year-long Ebola outbreak. On Monday, the trial’s cosponsors at the World Health Organization and the National Institutes of Health announced that two of the experimental treatments appear to dramatically boost survival rates.

While an experimental vaccine previously had been shown to shield people from catching Ebola, the news marks a first for people who already have been infected. “From now on, we will no longer say that Ebola is incurable,” said Jean-Jacques Muyembe, director general of the Institut National de Recherche Biomedicale in the DRC, which has overseen the trial’s operations on the ground.

Starting last November, patients in four treatment centers in the country’s east, where the outbreak is at its worst, were randomly assigned to receive one of four investigational therapies—either an antiviral drug called remdesivir or one of three drugs that use monoclonal antibodies. Scientists concocted these big, Y-shaped proteins to recognize the specific shapes of invading bacteria and viruses and then recruit immune cells to attack those pathogens. One of these, a drug called ZMapp, is currently considered the standard of care during Ebola outbreaks. It had been tested and used during the devastating Ebola epidemic in West Africa in 2014, and the goal was to see if those other drugs could outperform it. But preliminary data from the first 681 patients (out of a planned 725) showed such strong results that the trial has now been stopped.