Lifeboat Foundation

Mumbai: A five-year-old child from Majalgaon village in Beed, who may soon undergo a genital reconstruction surgery, was admitted to St George Hospital on Thursday. Parents of Aiman Khan, who was raised as a girl, have now made her Aadhaar number with the new male identity as Aman.

Medical superintendent Dr. Madhukar Gaikwad said the child’s sonography was carried out on Thursday. “We will be doing all the required medical examinations and then schedule the surgery.” The child’s karyotype study, which determines chromosomes, shows the presence of male XY chromosomes.

Plastic surgeon Dr. Rajat Kapoor, who evaluated the minor, has found the presence of testes, a male reproductive organ, and absence of female internal organs. He said the genitalia looks like that of a female due to underdevelopment.

Continue reading “Genital reconstruction: 5-year-old from Beed admitted to St George” »

Today, we want to point out a new publication that dives into the world of senolytics, which are drugs or therapies that seek and destroy harmful non-dividing cells that resist the programmed cell death known as apoptosis.

These cells linger in the body, and, as we age, more and more of them accumulate and contribute to the chronic age-related inflammation known as “inflammaging” while reducing tissue regeneration and repair and contributing to the development of various age-related diseases.

One approach to dealing with these problem cells is to tip them over the edge and cause them to self-destruct, thus removing them and the inflammation they cause. A new class of drugs known as senolytics was discovered a few years ago, and the interest in developing them to potentially combat age-related diseases has been growing rapidly.

Continue reading “A Review of Cellular Senescence and Senolytics” »

A new potential method to administer gene therapy without triggering an immune response.

Scientists at Stanford University School of Medicine managed to administer effective gene therapy in mice without triggering an autoimmune reaction. The research, led by Dr. Peggy Ho, Ph.D., was published in the Proceedings of the National Academy of Sciences [1].

Study abstract

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An in depth print cover story out on life extension by Forbes Africa—probably destined to become one of the main go-to articles for people on the continent seeking info on the topic. Myself, Aubrey de Grey, and others are featured in it. Excited to see #Africa join the race to overcome death and disease:

Science is pumping in billions searching for solutions that will help humans live longer – and better – and one day even indefinitely.

A new research discovered the mechanism behind the positive effect of consuming food rich in unsaturated fats. The role of the plasma protein- Apolipo IV as an inhibitor of aggregation of platelets for the diminishing occurrence of heart attack, stroke, atherosclerosis was established.

Foods high in unsaturated fats may protect against cardiovascular disease, and new research published today in Nature Communications has uncovered why.

Apolipoprotein A-IV, known as ApoA-IV, is a plasma protein. Levels of ApoA-IV increase after the digestion of foods, particularly foods high in unsaturated fats, such as olive oil. Higher levels of ApoA-IV in the blood have been reported to be associated with lower rates of cardiovascular disease.

Continue reading “How olive oil and sleep could stave off heart attacks and strokes—new study examines plasma protein’s role” »

The overarching goal of the talks, which open tomorrow at the United Nations in New York City, is crafting a new agreement to protect biodiversity in the high seas, which include two-thirds of the ocean. Much of discussions, which will run until 17 September, are expected to focus on long-standing proposals to establish protected zones where fishing and development would be limited or banned. But the negotiations also aim to replace today’s free-for-all scramble for marine genetic resources with a more orderly and perhaps fairer regime.

Nations open historic negotiations on marine biodiversity pact.

Los Angeles County officials launched a program Wednesday to help locate people with autism, Alzheimer’s disease or dementia who may wander off and go missing.

The program, called L.A. Found, will make use of bracelets that can be tracked through radio frequency by sheriff’s deputies. It will also create a new office, housed within the department of Workforce Development, Aging and Community Services, to coordinate a countywide response when somebody goes missing.

“If you get lost, we will help find you,” county Supervisor Janice Hahn, who championed the initiative, said at a news conference.

Continue reading “L.A. County Launches Tracking Program to Locate People With Dementia, Others Who Wander” »

More than a quarter (1.4 billion) of the world’s adult population were insufficiently active in 2016, putting them at greater risk of cardiovascular disease, type 2 diabetes, dementia, and some cancers, according to the first study to estimate global physical activity trends over time. The study was undertaken by researchers from the World Health Organization (WHO) and published in The Lancet Global Health journal.

Together, these estimates demonstrate that there has been little progress in improving physical activity levels between 2001 and 2016. The data show that if current trends continue, the 2025 global activity target of a 10% relative reduction in insufficient physical activity will not be met.

“Unlike other major global health risks, levels of insufficient physical activity are not falling worldwide, on average, and over a quarter of all adults are not reaching the recommended levels of physical activity for good health,” warns the study’s lead author, Dr. Regina Guthold of the WHO, Switzerland.

Continue reading “Globally, 1.4 billion adults at risk of disease from not doing enough physical activity” »

Principles of game theory offer new ways of understanding genetic behavior, a pair of researchers has concluded in a new analysis appearing in the Journal of the Royal Society Interface. Its work opens the possibility of comprehending biological processes, and specifically biochemistry, through a new scientific lens.

The exploration considers signaling game theory, which involves sender and receiver interactions with both seeking payoffs.

“The view of genes as players in a signaling game effectively animates genes and bestows simple utilities and strategies—thus, unique personalities—on them,” explains Bhubaneswar “Bud” Mishra, a professor at NYU’s Courant Institute of Mathematical Sciences, who co-authored the analysis with Steven Massey, an associate professor at the University of Puerto Rico. “In this view, the genome possesses characteristics of a molecular society, complete with deception, imitation, cooperation, and competition—not unlike human society. This adds a grandeur to a traditional view of life and the interactions it is made up of.”

Continue reading “Researchers outline game-theory approach to better understand genetics” »