Lifeboat Foundation

A great new biomarker for senescent cells is available and will allow researchers to more measure levels of aged cells easier and faster. Great news for gerontologists wishing to demonstrate changes to aged cell populations after therapies.

Scientists have discovered a new way to look for ageing cells across a wide range of biological materials; the new method will boost understanding of cellular development and ageing as well as the causes of diverse diseases.

Frustrated by the limitations of commercially available biomarkers — researchers led by The University of Manchester’s Professor Paul Townsend and senior author of the resulting paper, and honorary professor at Manchester, Professor Vassilis Gorgoulis, have developed a universally applicable method to assess senescence across biomedicine, from cancer research to gerontology.

Continue reading “New method to detect ageing cells – and aid rejuvenation therapies — developed” »

In Brief.

• Every year, more than 795,000 people in the United States have a stroke.
• A team of scientists has discovered a common mechanism chain leading to brain cell death which involves proteins eating away at a cell’s DNA.

A team of scientists has discovered that, despite having varied causes and symptoms, most brain diseases all share a common mechanism chain leading to brain cell death. The process, aptly named parthanatos after an enzyme called PARP and the Greek god of death, involves proteins eating away at the cell’s DNA.

Rapamycin could lead to the development of drugs to delay some aspects of aging in particular the immune systems decline with age.

Nearly a decade of research showing that Rapamycin makes mice live up to 60% longer, scientists are trying it out as an anti-aging drug in dogs and humans.

Researchers at the University of Washington’s Dog Aging Project gave rapamycin to 16 dogs and imaged their hearts.

Continue reading “Side Effects of Antiaging drug Rapamycin can be managed with lower doses and appears to improve the immune system, restore vitality and delay heart disease and dementia” »

Summary: Researchers have identified a set of heat sensing neurons that prompt both nervous system and behavioral changes that help cool the body.

Source: NIH.

The body’s temperature is closely regulated. We sense temperature changes in the environment through specialized nerve cells in the outer layers of the skin. If we are too hot or too cold, our nervous system activates responses to help change our temperature. We can sweat to cool down or shiver to generate heat. Our blood vessels can constrict to conserve heat or expand to release heat. To avoid discomfort, we sometimes seek out different environments―choosing to go into an air conditioned room or sit by a heater.

In Brief.

Researchers have a new way to deliver antiobesity drugs to specific locations of the body by using nanoparticles, effectively stimulating weight loss without any harmful side effects.

Researchers from MIT, Brigham, and Women’s Hospital have recently tested a new way to stimulate fat loss through a pair antiobesity drugs. In this novel method, they made use of nanoparticles to deliver them to specific areas of the body.

Continue reading “Antiobesity Drugs In Nanoparticles Target Fat Cells Like Missiles” »

In our project to “print” skin cells on burn wounds.we place cells in vials, rather than in cartridges, and “print” them through an ink jet printer head.

Xconomy National —

Drugs that use molecular scissors to snip out or replace defective genes. Altered mosquitoes meant to sabotage entire disease-carrying populations. Both are potential uses of genome editing, which thanks to the CRISPR-Cas9 system has spread throughout the world’s biology labs and is now on the doorstep of the outside world. But with its first applications could also come unintended consequences for human health and the environment. The U.S. Defense Advanced Research Projects Agency—a famed military R&D group—wants to finance safety measures for the new gene-editing age.

The idea for the funding program, called Safe Genes, is to get out ahead of problems that could bring the field to a screeching halt. “We should couple innovation with biosecurity,” DARPA program manager Renee Wegrzyn, said Tuesday at the SynBioBeta conference in South San Francisco. “We need new safety measures that don’t slow us down. You have brakes in your car so that you can go fast but can stop when you need to.”

Continue reading “With New Program, DARPA To Encourage Safety ‘Brakes’ For Gene Editing” »

You really have to wonder sometimes.

THE futuristic world depicted in the classic science-fiction film Fantastic Voyage, starring Raquel Welch in a very clingy catsuit, could very soon be a reality as scientists have discovered a way of shrinking vehicles that could be placed inside the human body.

The Nobel Prize in chemistry was awarded on Wednesday to scientists based in the US, France, and the Netherlands for breakthroughs in designing molecular machines that can carry out tasks— and even mimic a four-wheel-drive car — when given a jolt of energy.

Winners J. Fraser Stoddart, Jean-Pierre Sauvage, and Bernard L. Feringa discovered how to build tiny motors — 1,000 times thinner than a strand of hair.

The machinery includes rings on axles, spinning blades, and even unimaginably small creations consisting of only a few molecules that can lift themselves off a surface like tiny robots rising on tip-toe. Those molecular robots can pluck, grasp, and connect individual amino acids. The machines can also be used as a novel mechanism of drug delivery.