Lifeboat Foundation

New research from Oregon Health & Science University could one day lead to therapies that prevent or treat diseases and infections tied to a protein that’s found in all human cells.

A study published today in the journal Molecular Cell describes how the protein ubiquitin is modified during bacterial infection.

The study details the steps taken to create a form of the protein known as lysine 6 polyubiquitin, where a long chain of ubiquitin molecules are linked through the amino acid lysine. This form of ubiquitin helps cells communicate by sending a molecular message—communication that remains poorly understood.

Google has released a new Pro model of its latest AI, Gemini, and company sources say it has outperformed GPT-3.5 (the free version of ChatGPT) in widespread testing. According to performance reports, Gemini Ultra exceeds current state-of-the-art results on 30 of the 32 widely-used academic benchmarks used in large language model (LLM) research and development. Google has been accused of lagging behind OpenAI’s ChatGPT, widely regarded as the most popular and powerful in the AI space. Google says Gemini was trained to be multimodal, meaning it can process different types of media such as text, pictures, video, and audio.

Insider also reports that, with a score of 90.0%, Gemini Ultra is the first model to outperform human experts on MMLU (massive multitask language understanding), which uses a combination of 57 subjects such as math, physics, history, law, medicine and ethics for testing both world knowledge and problem-solving abilities.

The Google-based AI comes in three sizes, or stages, for the Gemini platform: Ultra, which is the flagship model, Pro and Nano (designed for mobile devices). According to reports from TechCrunch, the company says it’s making Gemini Pro available to enterprise customers through its Vertex AI program, and for developers in AI Studio, on December 13. Reports indicate that the Pro version can also be accessed via Bard, the company’s chatbot interface.

The model can help evolve “better methods for growing cells for blood transfusions, novel cell therapies, and hematopoietic stem cell transplants.”

Remarkably, heX-Embryoid models developed structures akin to blood islands, the initial sites supporting the generation of blood cells in developing embryos. The study identified progenitors for red blood cells, platelets, and various white blood cell types—a pivotal advancement in the field, according to the team.

Researchers claim the model successfully replicated a process closely resembling the initial stages of blood production in humans. “This is exciting because there are extensive possibilities to apply this model to better understand how blood is formed and develop better methods for growing cells for blood transfusions, novel cell therapies, and hematopoietic stem cell transplants,” said Mo Ebrahimkhani, senior author and an associate professor at the Pittsburgh Liver Institute and the Department of Bioengineering at Pitt, in a statement.

Continue reading “Scientists craft embryo model mimicking early human blood development” »

Tiny made from human windpipe cells encouraged damaged neural tissue to repair itself in a lab experiment — potentially foreshadowing a future in which creations like this patrol our bodies, healing damage, delivering drugs, and more.

The background: In a study published in 2020, researchers at Tufts University and the University of Vermont (UVM) harvested and incubated skin cells from frog embryos until they were tiny balls.

Continue reading “Tiny biobots surprise their creators by healing wound” »

Cloning, a topic that has captured the imagination of many, continues to be a subject of scientific interest, ethical debates, and speculative musings. While its various forms and implications have been widely discussed, this article aims to provide an overview of cloning, present examples of successful cloning in different organisms, explore the mechanisms involved, and address the reports and speculations surrounding possible human cloning.

Understanding Cloning: Cloning is the process of creating an organism that is genetically identical to another individual. It can occur naturally, such as with identical twins, or it can be achieved artificially through scientific techniques. Artificial cloning techniques include somatic cell nuclear transfer (SCNT), where the nucleus of a donor cell is transferred into an enucleated egg cell, and reproductive cloning, which aims to create a living copy of an existing organism.

A recent study conducted by Oregon State University has unveiled new insights into how certain polyunsaturated fatty acids, specifically omega 3, combat a severe liver condition. This discovery paves the way for novel drug research for nonalcoholic steatohepatitis (NASH), a disease currently without any FDA-approved treatments.

Scientists led by Oregon State’s Natalia Shulzhenko, Andrey Morgun and Donald Jump used a technique known as multi-omic network analysis to identify the mechanism through which dietary omega 3 supplements alleviated nonalcoholic steatohepatitis, usually abbreviated to NASH.

The mechanism involves betacellulin, a protein growth factor that plays multiple positive roles in the body but also contributes to liver fibrosis, or scarring, and the progression to cirrhosis and liver cancer.

Osaka-based Marukan Co., Ltd., the maker of a new range of nutritional cat food with AIM protein to prevent kidney disease, wants to help extend the lives of cats to 30 years.

Learn more about a protein-enriched cat food aiming to help cats live longer.

A stroke happens when blood flow is lost to part of the brain. Your brain cells cannot get the oxygen and nutrients they need from blood, and they start to die in a few minutes. This can cause lasting brain damage, long-term disability, or even death.

A stroke can occur when an obstruction such as a blood clot travels from another part of the body and lodges inside an artery in the brain.

When an arterial wall becomes damaged, various types of emboli, or obstructions, can form. Emboli can be made up of various substances such as platelets, elements in the blood that help it clot, blood clots that form elsewhere and pass to the damaged area, cholesterol, or a combination of things.

Continue reading “Stroke — Health Video: MedlinePlus Medical Encyclopedia” »

Headquartered in Oxford, UK, MitoRx is working on orally delivered mitochondrial protective therapeutics targeting mitochondrial dysfunction linked to the progression of conditions such as Duchenne muscular dystrophy and Huntington’s disease, along with other neurodegenerative diseases. The company says the new funding will be allocated towards its preclinical work in Huntington’s disease, activating its first neurodegenerative disease program, and exploring research collaborations and partnerships.

MitoRx anticipates delivering preclinical results in Duchenne muscular dystrophy, Huntington’s disease, and COPD next year.

“Interim results in our Duchenne program demonstrate that our muscle-penetrative lead asset preserves strength in oxidative muscle, and confirms mitochondrial modulation,” said Dr Christine Charman, Chief Development Officer at MitoRx. “These results will be presented at the Muscular Dystrophy Association Clinical and Scientific Conference in Orlando during March 2024.”