The gut microbiota is a key player in multiple facets of human health, influencing disease development and prevention. An interdisciplinary collaboration is needed to unravel its complexities and to finding potential avenues for therapeutic interventions.
Explore the following trending articles in Frontiers in Cellular and Infection Microbiology and Frontiers in Gastroenterology.
CAR T-cell (chimeric antigen receptor) therapy, a promising form of immunotherapy, involves reprogramming the patient’s T cells to enhance their ability to identify and combat antigens on the surface of cancer cells.
However, this therapy, which is currently approved for the treatment of leukemia and lymphoma, has a significant downside. During the process of destroying cancer cells, many of the engineered T cells get contaminated with residual cancer antigens, leading them to attack fellow T cells. This eventually results in a decrease in the body’s population of cancer-fighting cells, opening the door for a recurrence of cancer.
A new Yale study, however, has identified a way to tame the self-destructive tendencies of these killer T cells. Simply fusing a molecular tail onto the engineered T cells used in therapy, researchers say, can inhibit their proclivity to attack each other. The study was published July 27 in the journal Nature Immunology.
Could this be the future of medicine?
In order for chatbots to be useful to doctors and other health professionals, they are going to need access to the latest research. But current models simply don’t have access to data beyond their latest update. Daniel Nadler has been working to resolve this issue with his new startup OpenEvidence.
He plans to achieve his lofty goal by “marrying these language models with a real-time firehose of clinical documents,” Nadler told Forbes on Thursday. He claims that his new model “can answer with an open book, as opposed to a closed book.”
Science: In my opinion the main cause of aging is the accumulation of mutations in DNA 🧬 more than telomere size reduction or “toxin’s”. But the control of these “toxins” together with drug’s that simulate the restriction of calories and the transfusion of blood from young people to old people. And future drugs to make the telomeres grow again.
These four treatments together maybe can promote life extension. I am also enthusiastic in regenerative treatment with stem cells and “replace” old organs by new one’s growing in lab from stem cells. However I believe that immortality only when you make the enzymes “fix” in 100% the mutations caused by radicals.
High levels of toxic chemicals in the body, such as formaldehyde, which is best known as an embalming agent, have recently been found to be naturally made by cells and also to cause ageing.
Continue reading “Scientists in breakthrough towards secret of eternal youth” »
Recent developments in various domains have led to a growing interest in the potential of artificial intelligence to enhance our lives and environments. In particular, the application of artificial intelligence in the management of complex human diseases, such as cancer, has garnered significant attention. The evolution of artificial intelligence is thought to be influenced by multiple factors, including human intervention and environmental factors. Similarly, tumors, being heterogeneous and complex diseases, continue to evolve due to changes in the physical, chemical, and biological environment. Additionally, the concept of cellular intelligence within biological systems has been recognized as a potential attribute of biological entities. Therefore, it is plausible that the tumor intelligence present in cancer cells of affected individuals could undergo super-evolution due to changes in the pro-tumor environment. Thus, a comparative analysis of the evolution of artificial intelligence and super-complex tumor intelligence could yield valuable insights to develop better artificial intelligence-based tools for cancer management.
Tumor evolution refers to the changes that occur in a cancerous tumor over time as it grows and spreads (Hanahan and Weinberg, 2011; Lyssiotis and Kimmelman, 2017). These changes are the result of genetic mutations and changes in gene expression that can give rise to new subpopulations of cells within the tumor (Lyssiotis and Kimmelman, 2017; Balaparya and De, 2018). Over time, these subpopulations may accumulate subsequent mutations that confer enhanced survival and heightened proliferative capacity, thereby culminating in the emergence of a more formidable tumor exhibiting either heightened aggressiveness or treatment resistance (Balaparya and De, 2018; Gui and Bivona, 2022; Shin and Cho, 2023). Tumor evolution can have important implications for cancer diagnosis and treatment.
The U.S Food and Drug Administration (FDA) has approved a new drug combination for men with metastatic, castration-resistant prostate cancer (mCRPC) and certain DNA repair gene mutations, widening treatment options for this large patient population.
The androgen-receptor inhibitor enzalutamide plus the PARP inhibitor talazoparib can now be used as first-line treatment for mCRPC patients who have homologous recombination repair (HRR) gene alterations.
#MetastaticProstateCancer.
Continue reading “FDA Approves First-Line Enzalutamide/Talazoparib Combo in Prostate Cancer” »
Rothschild calls this “living tech,” which starts with the power of the cell. Microscopic organisms will produce silk, wool, latex, silica, and other materials. We’ll send digital information to biofactories on Mars through DNA sequences. We’ll generate and store power using living organisms. Rothschild said one of her students incorporated silver atoms into plant DNA to make an electrical wire.
“Once you think of life as technology,” Rothschild said, “you’ve got the solution.”
Continue reading “How Humans Will Become a Multi-Planetary Species” »
The first generalist medical AI system is out. DeepMind just announced Med-PaLM M, a Multimodal Generative AI model that understands:
The World Health Organization stated it’s possible but based this on limited evidence and no explanation of the mechanism for causing it.
One of the challenges in treating cancer is stopping it from metastasizing, and a new study reveals one of the fundamental mechanisms through which this happens. Now we know about this mechanism, perhaps we can stop it.
Key to this newly discovered process is GRP78, and it’s what’s known as a chaperone protein. It’s a type of protein that lends a hand in the folding or unfolding of larger proteins, basically building them up (or tearing them down), which then affects whether they’re biologically active and functional.
A team led by the Keck School of Medicine at the University of Southern California (USC) in the US found that cancer cells can hijack GRP78, using the protein to spread further in the body and resist treatment.
