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Archive for the ‘biotech/medical’ category: Page 65

Jun 27, 2024

Tiny Titan: MIT’s Revolutionary Coin-Sized 3D Printer Fits in Your Pocket

Posted by in categories: 3D printing, biotech/medical, computing, engineering

Researchers from MIT and the University of Texas have developed a prototype for a handheld, chip-based 3D printer using a photonic chip that emits beams of light to cure resin into solid objects. This innovative technology could revolutionize the production of customized, low-cost objects on-the-go and has potential applications in medical and engineering fields.

Portable 3D Printing Technology

Imagine a portable 3D printer you could hold in the palm of your hand. The tiny device could enable a user to rapidly create customized, low-cost objects on the go, like a fastener to repair a wobbly bicycle wheel or a component for a critical medical operation.

Jun 27, 2024

Unlocking Human Brain Evolution

Posted by in categories: biotech/medical, evolution, neuroscience

Summary: Researchers made a significant discovery in the study of human brain evolution, identifying epiregulin as a key factor in the expansion of the human neocortex. By comparing brain development between mice and humans and utilizing 3D brain organoids, the team found that epiregulin promotes the division and expansion of stem cells, crucial for neocortex development.

This study, which utilized cutting-edge 3D culture technology, suggests that the quantity of epiregulin, rather than its presence or absence, distinguishes human brain development from that of other species, including primates like gorillas. The research offers new insights into what makes the human brain unique and underscores the value of innovative methodologies in understanding complex evolutionary processes.

Jun 27, 2024

Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons

Posted by in categories: biotech/medical, neuroscience

Development of a cognitive enhancer based on preclinical findings has translational potential (Stepan et al., in 30 April 2024 issue).

Jun 27, 2024

Advances in the study of the structure that is formed around gold nanoparticles

Posted by in categories: biotech/medical, nanotechnology

Gold nanoparticles have been the subject of intense research for several decades due to their interesting applications in fields such as catalysis and medicine. “Surface ligands” are organic molecules typically present on the surface of gold nanoparticles. During synthesis, these surface ligands play an important role in controlling the size and shape of the nanoparticles.

For several decades, the CIC biomaGUNE team led by Ikerbasque Research Professor Luis Liz-Marzán has studied in detail the growth mechanisms and properties of these nanoparticles. Despite numerous advances that have recognized the importance of surface ligands, many questions remain about their exact behavior during and after growth. Direct observation of surface ligands and their interface with gold nanoparticles has therefore been a long-standing goal for many scientists in this field.

Transmission Electron Microscopy (TEM) is the technique most widely used to investigate nanoparticles. However, the study of surface ligands by means of TEM presents significant challenges; the reason is that the ligands are sensitive to the electron beam, their contrast is limited and their structure in vacuum differs from their native state in solution.

Jun 27, 2024

Anti-aging molecule successfully restores multiple markers of youth

Posted by in categories: biotech/medical, life extension, neuroscience

In pre-clinical trials, a small molecule effectively regrew neurons, reduced inflammation, and improved memory, speed, coordination, grip strength, and more. The finding could have a profound impact on aging and the diseases that accompany it.

In conducting the research, scientists at the University of Texas MD Anderson Cancer Center, turned their focus to telomerase reverse transcriptase (TERT), an enzyme that is known to help synthesize and extend telomeres, the protective caps at the ends of chromosomes that help cells divide. TERT levels are reduced as we age.

Without sufficient levels of TERT, when our telomeres shrink or get seriously modified, they can lead to a process that continually damages our DNA, which causes cells to release inflammatory compounds that can in turn lead to aging, tissue damage, and cancer.

Jun 27, 2024

Can MRI Help Elucidate Iron-Based Neurotoxicity?

Posted by in categories: biotech/medical, neuroscience

A new technique combining magnetic resonance imaging and x-ray fluorescence can characterize, with single-neuron resolution, the presence of toxic forms of iron that might be associated with neurodegenerative diseases.

Iron plays a major role in life. Most obviously, it keeps us alive, helping to ferry oxygen around our bloodstreams. It is also essential in cellular energy production, in the immune-system response, and in brain function—where it helps catalyze the synthesis of dopamine and other neurotransmitters. Iron can, however, be a double-edged sword. An iron excess has been implicated in many ailments, including neurodegenerative conditions such as Alzheimer’s, multiple sclerosis, and Parkinson’s disease—where dopaminergic neurons (neurons that use iron to synthesize dopamine) degenerate. It is thought that the toxicity of iron depends on how it is stored: iron firmly bound within proteins such as ferritin may be less toxic than iron more loosely bound to low-affinity sites, where it is more able to participate in reactions that generate cell-damaging hydroxyl radicals [1].

Jun 27, 2024

Researchers capture detailed picture of electron acceleration in one shot

Posted by in categories: biotech/medical, quantum physics

Adjusting experimental methods achieved the first “single-shot” diagnosis of electron acceleration through a laser wakefield accelerator along a curved trajectory, according to a recent study led by University of Michigan researchers. The findings are published in the journal Physical Review Letters.

This optical-based technique could help engineers develop more powerful electron accelerators for fundamental studies of quantum and —or more compact accelerators for use in medicine and industry.

Compared to traditional accelerators which can be kilometers long, laser wakefield accelerators can apply 1,000 times more energy per meter, allowing a vastly more compact design able to fit into a large room.

Jun 27, 2024

Revolutionizing Regeneration: Rat Stem Cells Restore Mouse Brain Circuits

Posted by in categories: biotech/medical, evolution, neuroscience

Research teams have successfully regenerated mouse brain circuits using rat stem cells, showcasing a new method for restoring brain function and studying interspecies brain development.

These findings open up possibilities for treating neurological diseases and understanding brain evolution, while also hinting at future clinical applications and ethical challenges in using similar techniques for human organ transplantation.

Scientists regenerate neural pathways in mice with cells from rats.

Jun 27, 2024

MIT Reveals Hidden Codes in DNA: A Breakthrough That Could Revolutionize Medicine

Posted by in categories: biotech/medical, genetics

MIT researchers have innovated a method to observe the interaction between genes and enhancers by monitoring their activation times, helping to pinpoint drug targets for genetic disorders. This technique also enhances understanding of eRNA’s function in gene regulation and disease treatment.

Gene Expression and Enhancer Mapping

Although the human genome contains about 23,000 genes, only a fraction of those genes are turned on inside a cell at any given time. The complex network of regulatory elements that controls gene expression includes regions of the genome called enhancers. These are often located far from the genes that they regulate.

Jun 27, 2024

Non-Coding RNA can Beneficially Boost Gene Activity in Cells

Posted by in category: biotech/medical

Proteins carry out many of the essential function of cells, and scientists have spent years learning about the expression of protein-coding genes. When genes are active, they are transcribed as messenger RNA (mRNA) molecules, which are then exported from the nucleus of the cell, where the DNA is kept, and into the cytoplasm, where mRNA molecules are translated into proteins. But many RNA molecules that do not code for protein are also exported from the nucleus and into the cytoplasm.

Scientists wanted to know more about what this non-coding RNA is doing, especially since it can often be found at high levels. Reporting in Nature, scientists have now used yeast cells to show that many of these non-coding RNA molecules are antisense RNAs (asRNAs), which have sequences that are complementary to mRNAs. So the right asRNA can anneal to its mRNA match. This turns out to promote the export of mRNAs from the nucleus to the cytoplasm, which boosts gene expression; a kind of “superhighway” for the transport of mRNAs is created with asRNAs to accelerate gene activity.

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