Throughout life, cells of the body acquire somatic mutations. In frozen post-mortem human brains, researchers from Yale University have found that somatic, or non-inherited, mutations are considerably more likely to accumulate in roughly 6% of brains, and these “hypermutable” brains are typically 40 years of age or older.
The behavior, comparable to clonal hematopoiesis in the bone marrow that can result in blood cancer in elderly people, is attributed to cell lines with mutations that outcompete other cell lines.
This is the first large-scale study of somatic mutations in human brains. Scientists were not expecting to find this hypermutability in older populations.
Four billion years ago, the Earth looked very different than it does today, devoid of life and covered by a vast ocean. Over the course of millions of years, in that primordial soup, life emerged. Researchers have long theorized how molecules came together to spark this transition. Now, scientists at Scripps Research have discovered a new set of chemical reactions that use cyanide, ammonia and carbon dioxide—all thought to be common on the early earth—to generate amino acids and nucleic acids, the building blocks of proteins and DNA.
“We’ve come up with a new paradigm to explain this shift from prebiotic to biotic chemistry,” says Ramanarayanan Krishnamurthy, Ph.D., an associate professor of chemistry at Scripps Research, and lead author of the new paper, published July 28, 2022 in the journal Nature Chemistry. “We think the kind of reactions we’ve described are probably what could have happened on early earth.”
In addition to giving researchers insight into the chemistry of the early earth, the newly discovered chemical reactions are also useful in certain manufacturing processes, such as the generation of custom labeled biomolecules from inexpensive starting materials.
Self-organizing lasers could lead to new materials for sensing, computing, light sources, and displays by mimicking features of living systems.
Although many artificial materials have advanced properties, they have a long way to go to combine the versatility and functionality of living materials that can adapt to their situation. For example, in the human body bone and muscle continuously reorganize their structure and composition to better sustain changing weight and level of activity.
Now, scientists have demonstrated the first spontaneously self-organizing laser device, which can reconfigure when conditions change.
Human-like temporal variability in movements is a powerful hint that humans use to ascribe humanness to robots.
A team of researchers at the University of Geneva has found that ketamine is unlikely to be addictive to people who use it for extended periods of time. In their paper published in the journal Nature, the group describes their study of the impact of the synthetic compound on the brains of mice and what they learned about its impact on different brain regions. Rianne Campbell and Mary Kay Lobo, with the University of Maryland School of Medicine have published a News and Views piece in the same journal issue outlining the work done by the team in Switzerland.
A team of researchers at the University of Geneva has found that ketamine is unlikely to be addictive to people who use it for extended periods of time. In their paper published in the journal Nature, the group describes their study of the impact of the synthetic compound on the brains of mice and what they learned about its impact on different brain regions. Rianne Campbell and Mary Kay Lobo, with the University of Maryland School of Medicine have published a News and Views piece in the same journal issue outlining the work done by the team in Switzerland.
This single study has cracked open an entirely new field of scientific research, which Hadany calls phytoacoustics.
Veits wants to know more about the underlying mechanisms behind the phenomenon the research team observed. For instance, what molecular or mechanical processes are driving the vibration and nectar response? She also hopes the work will affirm the idea that it doesn’t always take a traditional sense organ to perceive the world.
“Some people may think, How can [plants] hear or smell?” Veits says. “I’d like people to understand that hearing is not only for ears.”
Why do some individuals always seem to be healthy while other people often get viruses and bacteria? Despite sleeping close to their sick partner every night, how can a sick person’s spouse avoid contracting their illness? During the COVID-19.
First identified in 2019 in Wuhan, China, Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has spread globally, resulting in the 2019–20 coronavirus pandemic.
“DEATH DEFANGED Cryonics, Cryothanasia and the Future of Sentience” with David Pearce, Author, Philosopher and well-known TransHumanistThis service will be on ZOOM and YouTube Live Stream only, not in person. Zoom at 6:00 PM Eastern Time. Live Stream at 7:00 PM Eastern Time. Stay after the close of the YouTube streaming for the Zoom After Party until??:00 pm. Enjoy fellowship in the extended discussions with Neal and Immortalists & Friends from Around the World, sharing bold ideas on health, longevity, and technology!(Note: Mr. Pearce was scheduled last month to give a presentation but due to circumstances beyond our control we did not have that presentation. We look forward this month to have David Pearce join us!)David Pearce is the author of 4 major works:“The Hedonistic Imperative”, “The Biointelligence Explosion: How Recursively Self-Improving Organic Robots will Modify their Own Source Code and Bootstrap Our Way to Full-Spectrum Superintelligence”, “Singularity Hypotheses: A Scientific and Philosophical Assessment”, & “Can Biotechnology Abolish Suffering?” The Hedonistic Imperative (1995) advocates the use of biotechnology to abolish suffering throughout the living world. In 1998, he co-founded the World Transhumanist Association (H+) with Nick Bostrom. Transhumanists believe in the use of technology to overcome our biological limitations. Currently, Pearce is a fellow of the Institute for Ethics and Emerging Technologies, and sits on the futurist advisory board of the Lifeboat Foundation. He is also the director of bioethics of Invincible Wellbeing and is on the advisory boards of the Center on Long-Term Risk, the Organization for the Prevention of Intense Suffering and since 2021 the Qualia Research Institute. Please share this event with someone that you care about. Would you like to make a Donation to Perpetual Life? Your donations help us grow & improve our services. To donate, go to our website http://Perpetual.Life and use the PayPal button at the top right of the page. Thank you for your generous donations, we appreciate it immensely!“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“ - Nikolai F. FedorovWe hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime. Working to Save Lives with Age Reversal Education. ========== Perpetual Life Creed ==========We believe that all of life is sacred and that we have been given this one life to make unlimited. We believe in our Creator’s divine plan for all of humanity to have infinite lifespans in perfect health and eternal joy, rendering death to be optional. By following our Gospel we achieve eternal life creating a heaven here on earth. We follow Nikolai Fyodorov, who taught that the transcendence of the creator will only be solved when humanity in our unified efforts become an instrument of universal resuscitation, when the divine word becomes our divine action. And we follow Arthur C. Clarke, who said “The only way to discover the limits of the possible is to go beyond them into the impossible.“And so, we enter each day energized in Spirit and empowered by the words of our prophets to live in joy, serving our creator and all of mankind, Forever and Ever.==========Wishing you Perfect Health and Great Longevity!Perpetual Life, a science-faith based church is open to people of all faiths & belief systems. We are non-denominational & non-judgmental and a central gathering place of Immortalists & Transhumans. What unites us is our common faith, belief and desire in Unlimited Life Spans. We are located in Pompano Beach FL at 950 South Cypress Road.
A single chemical could be responsible for whether people go bald or not, a new study has found.
In the UK, approximately two thirds of men will face male pattern baldness. The study says the discovery of the chemical could “not only treat baldness, but ultimately speed wound healing”.
Researchers at the University of California, Riverside, found that a sole chemical is responsible for hair follicles dividing and dying.
The platform, still in the early development phase, is called Druglike, according to a press release that circulated on July 25. Its goals are ostensibly lofty, but the details are extremely sketchy, and Shkreli’s intentions have already drawn skepticism. It’s also unclear whether the enterprise will run Shkreli afoul of his lifetime ban from the pharmaceutical industry, which stemmed from the abrupt and callous 4,000 percent price hike of a life-saving drug that made him infamous.
Shkreli, who is named as a cofounder of Druglike, says the platform aims to make early-stage drug discovery more affordable and accessible. “Druglike will remove barriers to early-stage drug discovery, increase innovation and allow a broader group of contributors to share the rewards,” Shkreli said in the press release. “Underserved and underfunded communities, such as those focused on rare diseases or in developing markets, will also benefit from access to these tools.”
Generally, early-stage drug development can sometimes involve virtual screens to identify potential drug candidates. In these cases, pharmaceutical scientists first identify a “target”—a specific compound or protein that plays a critical role in developing a disease or condition. Then researchers look for compounds or small molecules that could interfere with that target, sometimes binding or “docking” directly to the target in a way that keeps it from functioning. This can be done in physical labs using massive libraries of compounds in high-throughput chemical screens. But it can also be done virtually, using specialized software and a lot of computing power, which can be resource-intensive.
