Lifeboat Foundation

𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐬𝐡𝐨𝐰𝐬 𝐢𝐧𝐯𝐞𝐬𝐭𝐢𝐠𝐚𝐭𝐢𝐨𝐧𝐚𝐥 𝐝𝐫𝐮𝐠 𝐟𝐨𝐬𝐭𝐞𝐫𝐬 𝐧𝐞𝐫𝐯𝐞 𝐫𝐞𝐩𝐚𝐢𝐫 𝐚𝐟𝐭𝐞𝐫 𝐢𝐧𝐣𝐮𝐫𝐲

Scientists from the University of Birmingham have shown that a brain-penetrating candidate drug currently in development as a cancer therapy can foster regeneration of damaged nerves after spinal trauma.

The research, published today in Clinical and Translational Medicine, used cell and animal models to demonstrate that when taken orally the candidate drug, known as AZD1390, can block the response to DNA damage in nerve cells and promote regeneration of damaged nerves, so restoring sensory and motor function after spinal injury.

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How the virus behind covid-19 enters the brain was somewhat of a mystery, but new evidence hints it may build tiny tubes from nose cells to brain cells that it can shuttle through.

Targeted repairs with ‘nicks’ of single DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

People who have at least two of the conditions type 2 diabetes, heart disease, or stroke are twice as likely to develop dementia. Research from Sweden’s Karolinska Institutet that was published in the journal Alzheimer’s.

Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.

US Rep Jason Crow, of the US House Intelligence Committee, warned that bio-weapons are being made that use a target’s DNA to only kill that person at a security forum on Friday.

New research from Binghamton University, State University of New York offers a second life for CDs: Turn them into flexible biosensors that are inexpensive and easy to manufacture.

In a paper published this month in Nature Communications, Matthew Brown, Ph.D. ‘22, and Assistant Professor Ahyeon Koh from the Department of Biomedical Engineering show how a gold CD’s thin metallic layer can be separated from the rigid plastic and fashioned into sensors to monitor electrical activity in human hearts and muscles as well as lactate, glucose, pH and oxygen levels. The sensors can communicate with a smartphone via Bluetooth.

The fabrication is completed in 20 to 30 minutes without releasing toxic chemicals or needing expensive equipment, and it costs about $1.50 per device. According to the paper, “this sustainable approach for upcycling electronic waste provides an advantageous research-based waste stream that does not require cutting-edge microfabrication facilities, expensive materials or high-caliber engineering skills.”

Researchers from the University of Michigan Rogel Cancer Center, studying the molecular landscape of over 500 patients with an aggressive form of multiple myeloma, discovered a prevalence of activated key oncogenic pathways in these patients, much more than previously thought. Upwards of 45–65% of NF-κB and RAS/MAPK pathways each had alterations. The study was published in Nature Communications.

Further, Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology, and his team found a link between mutations and RASopathies, a certain group of genetic syndromes, in patients with relapsed treatment-resistant multiple myeloma. This was the first observation of its kind.

The team compared the molecular makeup of patients with untreated multiple myeloma to those with the relapsed treatment-resistant version of the disease. Comparing these patients allowed researchers to describe drivers of the more aggressive form of multiple myeloma.

University of Iowa researchers have confirmed in a new study that a specific region in the brain is critical to governing the mind’s communication with the body’s motor control system. The findings could yield advances in treatment for Parkinson’s disease, as declining motor coordination is a central symptom of the disorder.

In experiments with humans, the researchers pinpointed the subthalamic nucleus as the region in the brain that communicates with the motor system to help the body stop an action. This communication is vital because it helps humans avoid surprises and react to potentially dangerous or unforeseen circumstances.

The subthalamic nucleus is a tiny grouping of cells that is part of the basal ganglia, which is a key circuit in controlling movement. The basal ganglia takes initial motor commands generated in the brain and either amplify or halt specific parts of those commands as they pass from the central nervous system to the spinal cord.

Figuring out what’s going on in the brain is generally considered to be somewhere between extremely difficult and impossible. One major challenge is that the best ways to do so are room-sized machines relegated to hospitals — but brain.space is hoping that its portable, powerful and, most importantly, user-friendly EEG helmet could power new applications and treatments at home and, as a sort of cork pop for its debut, in space.

Electroencephalography, or EEG, is an established method for monitoring certain signals the brain produces. An EEG can indicate which areas of the cortex are active, whether the user is concentrating, agitated, and so on. It’s not nearly as precise as an MRI, but all you need for an EEG is a set of electrical contacts on the scalp, while an MRI machine is huge, loud and incredibly expensive.

There’s been precious little advancement in EEG tech, though, and it’s often done more or less the same way it was done decades ago. Recently, that’s begun to change with devices like Cognixion’s, which uses re-engineered EEG to interpret specific signals with the goal of allowing people with motor impairments to communicate.