Lifeboat Foundation

This study presents a discovery in the fight against hepatocellular carcinoma (HCC) by identifying the protein Schlafen 11 (SLFN11) as a key factor influencing the effectiveness of immune checkpoint inhibitors (ICIs). Through comprehensive analysis using humanized orthotopic HCC mouse models and in vitro co-culture systems, the research unveils how SLFN11’s deficiency in tumor cells leads to an increase in C-C motif chemokine ligand 2 (CCL2) secretion. This phenomenon promotes the infiltration of immunosuppressive macrophages and leads to immune evasion. The study also showcases the therapeutic potential of blocking CCL2/CCR2 signaling to enhance the efficacy of ICIs in patients with low SLFN11 expression. These findings pave the way for future research to explore additional therapeutic targets within the immune landscape of HCC, offering hope for more effective treatments and improved patient outcomes.

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, with advanced stages showing dismal survival rates due to limited treatment efficacy. The efforts to improve the situation have focused on immunotherapies, such as immune checkpoint inhibitors (ICIs), though their success varies significantly among individuals due to the complex interplay of tumor growth and immune evasion within the tumor microenvironment (TME). Previous studies have hinted at the role of tumor-associated macrophages (TAMs) and chemokines like CCL2 in the functional remodeling of TAMs. However, a comprehensive understanding of the mechanisms driving immune evasion and therapy resistance in HCC has been lacking. This research proposes a solution by identifying SLFN11’s role in modulating the immune landscape of HCC, specifically its influence on macrophage polarization and CCL2 signaling. The outcome offers new avenues for enhancing ICI therapy effectiveness.

Continue reading “Liver Cancer: How Tackling a Protein Could Boost Immunotherapy Success” »

While taking snapshots with the high-speed “electron camera” at the Department of Energy’s SLAC National Acceleratory Laboratory, researchers discovered new behavior in an ultrathin material that offers a promising approach to manipulating light that will be useful for devices that detect, control or emit light, collectively known as optoelectronic devices, and investigating how light is polarized within a material. Optoelectronic devices are used in many technologies that touch our daily lives, including light-emitting diodes (LEDs), optical fibers and medical imaging.

As reported in Nano Letters (“Giant Terahertz Birefringence in an Ultrathin Anisotropic Semimetal”), the team, led by SLAC and Stanford professor Aaron Lindenberg, found that when oriented in a specific direction and subjected to linear terahertz radiation, an ultrathin film of tungsten ditelluride, which has desirable properties for polarizing light used in optical devices, circularly polarizes the incoming light.

Snapshot taken by SLAC’s high-speed electron camera, an instrument for ultrafast electron diffraction (MeV-UED), showing evidence of circular polarization of terahertz light by an ultrathin sample of tungsten ditelluride. (Sie et al., Nano Letters, 8 May 2024)

While taking snapshots with the high-speed electron camera at the Department of Energy’s SLAC National Acceleratory Laboratory, researchers discovered new behavior in an ultrathin material that offers a promising approach to manipulating light that will be useful for devices that detect, control or emit light, collectively known as optoelectronic devices, and investigating how light is polarized within a material. Optoelectronic devices are used in many technologies that touch our daily lives, including light-emitting diodes (LEDs), optical fibers and medical imaging.

As reported in Nano Letters, the team, led by SLAC and Stanford professor Aaron Lindenberg, found that when oriented in a specific direction and subjected to linear terahertz radiation, an ultrathin film of tungsten ditelluride, which has desirable properties for polarizing light used in optical devices, circularly polarizes the incoming light.

Terahertz radiation lies between the microwave and the infrared regions in the electromagnetic spectrum and enables novel ways of both characterizing and controlling the properties of materials. Scientists would like to figure out a way to harness that light for the development of future optoelectronic devices.

Up to 3% of people with diabetes have an allergic reaction to insulin. A team at Forschungszentrum Jülich has now studied a method that could be used to deliver the active substance into the body in a masked form—in the form of tiny nanoparticles.

The insulin is only released in the target organ when the pH value deviates from the slightly alkaline environment in the blood. The molecular transport system could also serve as a platform for releasing other drugs in the body precisely at the target site.

It’s an old dream in pharmacy: To deliver an active ingredient to the exact place in the body where it is most needed—a cancer drug, for example, directly to the tumor tissue. This minimizes its side effects on other organs and ensures that it has its maximum effect at its target.

Humanoids, robotic or virtual systems with body structures that resemble the human body, have a wide range of real-world applications. As their limbs and bodies mirror those of humans, they could be made to reproduce a wide range of human movements, such as walking, crouching, jumping, swimming and so on.

Computationally generating realistic motions for virtual humanoid characters could have interesting implications for the development of video games, animated films, virtual reality (VR) experiences, and other media content. Yet the environments portrayed in video games and animations are often highly dynamic and complex, which can make planning motions for humanoids introduced in these environments more challenging.

Continue reading “A new model to plan and control the movements of humanoids in 3D environments” »

To create one-time cures for Alzheimer’s disease, researchers are investigating the application of CRISPR-Cas9 gene-editing for novel therapies. Cutting and pasting genes is difficult with current technology, but CRISPR gene editing may help later stages or those individuals with hereditary mutations. Variants in the lipid transport protein apolipoprotein E (APOE4) have been associated with late-onset Alzheimer’s disease, with a three-to twelve-fold increase in risk.

Researchers engineered the Christchurch gene variation into mice bearing human APOE4 using CRISPR. After that, these mice were crossed, resulting in progeny that carried one or two copies of the modified variation.

The group discovered that mice bearing a single copy of the APOE4-Christchurch variation exhibited a partial defense against Alzheimer’s disease. The disease did not exhibit typical symptoms in mice carrying two copies. The work mimics the advantageous effects of the Christchurch mutation to propose possible treatment strategies for Alzheimer’s disease associated with APOE4.

Ancient DNA from bones and teeth hints at a role of the plague in Stone Age population collapse. Contrary to previous beliefs, the plague may have diminished Europe’s populations long before the major plague outbreaks of the Middle Ages, new research published in the journal Nature shows.

In the 14th century Europe, the plague ravaged the population during the so-called “Black Death,” claiming the lives of nearly a third of the population.

But the plague arrived in Scandinavia several thousand years earlier, and despite several theories suggesting otherwise, the plague might have caused an epidemic, according to new research from the University of Copenhagen.

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In this video, we explore 20 emerging technologies changing our future, including super-intelligent AI companions, radical life extension through biotechnology and gene editing, and programmable matter. We also cover advancements in flying cars, the quantum internet, autonomous AI agents, and other groundbreaking innovations transforming the future.

Continue reading “20 Emerging Technologies That Will Change The Future” »

In early 2023, following an international conference that included dialogue with China, the United States released a “Political Declaration on Responsible Military Use of Artificial Intelligence and Autonomy,” urging states to adopt sensible policies that include ensuring ultimate human control over nuclear weapons. Yet the notion of “human control” itself is hazier than it might seem. If humans authorized a future AI system to “stop an incoming nuclear attack,” how much discretion should it have over how to do so? The challenge is that an AI general enough to successfully thwart such an attack could also be used for offensive purposes.

We need to recognize the fact that AI technologies are inherently dual-use. This is true even of systems already deployed. For instance, the very same drone that delivers medication to a hospital that is inaccessible by road during a rainy season could later carry an explosive to that same hospital. Keep in mind that military operations have for more than a decade been using drones so precise that they can send a missile through a particular window that is literally on the other side of the earth from its operators.

We also have to think through whether we would really want our side to observe a lethal autonomous weapons (LAW) ban if hostile military forces are not doing so. What if an enemy nation sent an AI-controlled contingent of advanced war machines to threaten your security? Wouldn’t you want your side to have an even more intelligent capability to defeat them and keep you safe? This is the primary reason that the “Campaign to Stop Killer Robots” has failed to gain major traction. As of 2024, all major military powers have declined to endorse the campaign, with the notable exception of China, which did so in 2018 but later clarified that it supported a ban on only use, not development—although even this is likely more for strategic and political reasons than moral ones, as autonomous weapons used by the United States and its allies could disadvantage Beijing militarily.