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The team, led by Dipanjan Pan, Dorothy Foehr Huck & J. Lloyd Huck Chair Professor in Nanomedicine and professor of materials science and engineering and of nuclear engineering, published their work —the first of its kind, they said—in ACS Nano.

“Borophene is a very interesting material, as it resembles carbon very closely including its atomic weight and electron structure but with more remarkable properties. Researchers are only starting to explore its applications,” Pan said.

“To the best of our knowledge, this is the first study to understand the biological interactions of borophene and the first report of imparting chirality on borophene structures.”

Researchers have developed a new vaccine technology that has been shown in mice to provide protection against a broad range of coronaviruses with potential for future disease outbreaks—including ones we don’t even know about. The results are published in the journal Nature Nanotechnology.

Skin functions as a sophisticated sensorial system in the human body, capable not only of detecting environmental stimuli—such as temperature, pressure, strain, and vibration—but also of actively responding to these changes. Among these, the temperature regulation capability of the skin plays a critical role in maintaining the stability of homeothermic animals.

An international team, led by researchers from Australia, have developed a system using nanotechnology that could allow people with diabetes to take oral insulin in the future. The researchers say the new insulin could be eaten by taking a tablet or even embedded within a piece of chocolate.

A team of chemists and bioengineers at Rice University and the University of Houston have achieved a significant milestone in their work to create a biomaterial that can be used to grow biological tissues outside the human body.

The results of a metagenomic study from the University of Trento suggest that the CRISPR toolbox will need to make room for another CRISPR enzyme. The disruption should be minimal because the newly identified enzyme is unusually compact. It consists of just over 1,000 amino acids. And yet it is also strongly active and highly precise. The hope is that it can be packaged with guide RNA within the tight quarters afforded by adeno-associated virus (AAV) vectors, and thereby expand the use of in vivo gene editing in therapeutic applications.

The study was led by Anna Cereseto, PhD, and Nicola Segata, PhD, of the department of cellular, computational, and integrative biology. Cereseto leads a laboratory that develops advanced genome editing technologies and their application in the medical sector. Segata is the head of a laboratory of metagenomics, where he studies the variety and characteristics of the human microbiome and its role in health. Their collaboration has led to the identification, in a bacterium of the intestine, of new CRISPR-Cas9 molecules that could have a clinical potential to treat genetic diseases.

Detailed findings from the study recently appeared in Nature Communications, in an article titled, “CoCas9 is a compact nuclease from the human microbiome for efficient and precise genome editing.”

Nature Biotechnology volume 42, pages 551–554 (2024) Cite this article.

Move over, graphene. There’s a new, improved two-dimensional material in the lab. Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Now, researchers at Penn State have made the material potentially more useful by imparting chirality — or handedness — on it, which could make for advanced sensors and implantable medical devices. The chirality, induced via a method never before used on borophene, enables the material to interact in unique ways with different biological units such as cells and protein precursors.

The team, led by Dipanjan Pan, Dorothy Foehr Huck & J. Lloyd Huck Chair Professor in Nanomedicine and professor of materials science and engineering and of nuclear engineering, published their work — the first of its kind, they said — in ACS Nano.

“Borophene is a very interesting material, as it resembles carbon very closely including its atomic weight and electron structure but with more remarkable properties. Researchers are only starting to explore its applications,” Pan said. “To the best of our knowledge, this is the first study to understand the biological interactions of borophene and the first report of imparting chirality on borophene structures.”

Ever since superconductivity was discovered in the early 1900s, it has both captivated and mystified scientists. Superconductors conduct electricity with virtually zero resistance, allowing for highly efficient transmission of electrical currents. Among other uses, they create the strong magnetic fields we depend on for medical imaging with MRI machines.

The first known superconductor, mercury, only works when the temperature dips just below-450 F. Copper-containing materials called cuprates were found in the ’80s to become superconductors at warmer temperatures, though still inconveniently cold — closer to-200 F. Understanding how these so-called high-temperature superconductors work could eventually lead to ones that can operate in less frigid conditions.

One potential hallmark of high-temperature superconductors has remained purely theoretical, until now. A team of scientists, including several from the U.S. Department of Energy’s (DOE) Argonne National Laboratory, has observed an elusive state of matter called quantum spin nematic. The study, which was published in the journal Nature (“Quantum spin nematic phase in a square-lattice iridate”), used the Advanced Photon Source (APS), a DOE Office of Science user facility at Argonne that also happens to use superconductors. The results lend insight on both high-temperature superconductivity and some of the physics involved in quantum computing.