Lifeboat Foundation

Researchers at Washington University School of Medicine in St. Louis have found a new druggable pathway that potentially could be used to help prevent Alzheimer’s dementia.

Amyloid beta accumulation in the brain is the first step in the development of Alzheimer’s dementia. Scientists have poured countless hours and millions of dollars into finding ways to clear amyloid away before cognitive symptoms arise, with largely disappointing results.

In this study, published Aug. 24 in the journal Brain, researchers found a way to increase clearance of waste products from the brains of mice by ramping up a genetic quirk known as readthrough. This same strategy also may be effective for other neurodegenerative diseases characterized by the buildup of toxic proteins, such as Parkinson’s disease, the researchers said.

Life science continued dominating the research schedule aboard the International Space Station on Wednesday to benefit humans living on and off the Earth. The seven Expedition 67 orbital residents explored how living in microgravity affects tissue regeneration, crew psychology, and the human digestion system.

Learning to heal wounds in space is critical as NASA and its international partners plan crewed missions to the Moon, Mars, and beyond. Four station astronauts have been partnering together this week for the skin healing study taking place inside the Kibo laboratory module. Flight Engineers Kjell Lindgren, Bob Hines, and Jessica Watkins, all from NASA, with Samantha Cristoforetti of ESA (European Space Agency), are studying surgical techniques such as biopsies, suture splints, and wound dressing, inside Kibo’s Life Science Glovebox.

Scientists on Earth seek to identify the molecular mechanisms that occur during tissue regeneration in weightlessness. Observations may offer advanced therapies and provide insights into how space-caused accelerated skin aging affects an astronaut’s healing properties. The biomedical experiment may also contribute to better wound healing techniques on Earth.

The number of vulnerability disclosures impacting extended internet of things (XIoT) devices increased by 57% in the first half of 2022 compared to the previous six months, according to a new report by Team82, the research team of cyber-physical systems (CPS) security firm Claroty.

The research also found that vendor self-disclosures increased by 69%. This would be a first for the industry, which usually relies more for disclosures on independent research teams. According to Team82, the trend indicates that more operational technology (OT), IoT, and internet of medical things (IoMT) vendors are establishing vulnerability disclosure programs and dedicating more resources to them.

Additionally, fully or partially remediated firmware vulnerabilities increased by 79% over the same time period, a significant improvement considering the relative challenges in patching firmware versus software vulnerabilities.

The Tasmanian devil may hold the key to cancer immunity especially if we use crispr to edit it into our dna.

Evidence suggests newly evolved genes protect the iconic marsupials against devil tumor facial disease.

Talking about some of the ideas and philosophy surrounding life extension technologies. Our own psychology and coping mechanisms that view death as a good thing. The same way we used to see some diseases as a part of a gods plan. As soon as we cured these diseases, somehow they were not a part of gods plan anymore. The same will happen with aging and death, and that is just a matter of time. Picking apart some of the ways of thinking that suggest a longer life would be a boring or bad thing. We live for all of the pleasant and amazing experiences that we can have in the world, what else could possibly matter more. The end and absence of meaning (death) does not give life meaning. It is life that gives life meaning.

In order to bridge the gap between AI researchers and medical professionals we developed a very accessible free prototype system which can be used by medical professionals to understand the reality of Deep Learning tools for chest X-ray diagnostics.

“I believe we can train the algorithm not only to picture accurately a face you’re looking at, but also any face you imagine vividly, such as your mother’s,” explains Dado.

“By developing this technology, it would be fascinating to decode and recreate subjective experiences, perhaps even your dreams,” Dado says. “Such technological knowledge could also be incorporated into clinical applications such as communicating with patients who are locked within deep comas.”

Continue reading “‘Mind-Reading’ Technology Translates Brainwaves into Photos” »

The success of COVID-19 vaccines is a great example of gene medicine’s tremendous potential to prevent viral infections. One reason for the vaccines’ success is their use of lipid nanoparticles, or LNPs, to carry delicate messenger RNA to cells to generate and boost immunity. LNPs—tiny fat particles—have become increasingly popular as a carrier to deliver various gene-based medicines to cells, but their use is complicated because each LNP must be tailored specifically for the therapeutic payload it carries.

A team led by Hai-Quan Mao, a Johns Hopkins materials scientist, has created a platform that shows promise to speed up the LNP design process and make it more affordable. The new approach also can be adapted to other gene therapies.

“In a nutshell, what we have done is creating a method that screens lipid nanoparticle components and their proportions to quickly help identify and create the optimal design for use with various therapeutic genes,” said Mao, director of the Institute for NanoBioTechnology at Johns Hopkins Whiting School of Engineering and professor in the departments of Materials Science and Engineering and Biomedical Engineering.

The lead in some bullets used for hunting deer, moose, and elk is toxic to the humans who eat the harvested meat and to scavenger animals that feast on remains left in the field.

A team of researchers from the Canadian Light Source at the University of Saskatchewan (USask) and the College of Medicine at USask has for the first time used synchrotron imaging to study both the size and spread of bullet fragments in big game shot by hunters. Their findings were published today in PLOS ONE.

Continue reading “New research on the risks of lead exposure from bullets used in big game hunting” »