Lifeboat Foundation

At first glance, a pack of wolves has little to do with a vinaigrette. However, a team led by Ramin Golestanian, Director at the Max Planck Institute for Dynamics and Self-Organization, has developed a model that establishes a link between the movement of predators and prey and the segregation of vinegar and oil. They expanded a theoretical framework that until now was only valid for inanimate matter. In addition to predators and prey, other living systems such as enzymes or self-organizing cells can now be described.

Order is not always apparent at first glance. If you ran with a pack of wolves hunting deer, the movements would appear disordered. However, if the hunt is observed from a bird’s eye view and over a longer period of time, patterns become apparent in the movement of the animals. In physics, such behavior is considered orderly. But how does this order emerge? The Department of Living Matter Physics of Ramin Golestanian is dedicated to this question and investigates the physical rules that govern motion in living or active systems. Golestanian’s aim is to reveal universal characteristics of active, living matter. This includes not only larger organisms such as predators and prey but also bacteria, enzymes and motor proteins as well as artificial systems such as micro-robots. When we describe a group of such active systems over great distances and long periods of time, the specific details of the systems lose importance.

In Project Apollo, life support was based on carrying pretty much everything that astronauts needed from launch to splashdown. That meant all of the food, air, and fuel. Fuel in particular took up most of the mass that was launched. The enormous three-stage Saturn-V rocket was basically a gigantic container for fuel, and even the Apollo spacecraft that the Saturn carried into space was mostly fuel, because fuel was needed also to return from the Moon. If NASA’s new Orion spacecraft takes astronauts back to the Moon, they’ll also use massive amounts of fuel going back and forth; and the same is true if they journey to a near-Earth asteroid. However, once a lunar base is set up, astronauts will be able use microorganisms carried from Earth to process lunar rock into fuel, along with oxygen. The latter is needed not just for breathing, but also in rocket engines where it mixes with the fuel.

Currently, there are microorganisms available naturally that draw energy from rock and in the process release chemical products that can be used as fuel. However, as with agricultural plants like corn and soy, modifying such organisms can potentially make a biologically-based lunar rock processing much more efficient. Synthetic biology refers to engineering organisms to pump out specific products under specific conditions. For spaceflight applications, organisms can be engineered specifically to live on the Moon, or for that matter on an asteroid, or on Mars, and to synthesize the consumables that humans will need in those environments.

In the case of Mars, a major resource that can be processed by synthetic biology is the atmosphere. While the Martian air is extremely thin, it can be concentrated in a biological reactor. The principal component of the Martian air is carbon dioxide, which can be turned into oxygen, food, and rocket fuel by a variety of organisms that are native to Earth. As with the Moon rocks, however, genetic techniques can make targeted changes to organisms’ capabilities to allow them to do more than simply survive on Mars. They could be made to thrive there.

DARPA’s SIGMA+ program conducted a week-long deployment of advanced chemical and biological sensing systems in the Indianapolis metro region in August, collecting more than 250 hours of daily life background atmospheric data across five neighborhoods that helped train algorithms to more accurately detect chemical and biological threats. The testing marked the first time in the program the advanced laboratory grade instruments for chemical and biological sensing were successfully deployed as mobile sensors, increasing their versatility on the SIGMA+ network.

“Spending a week gathering real-world background data from a major Midwestern metropolitan region was extremely valuable as we further develop our SIGMA+ sensors and networks to provide city and regional-scale coverage for chem and bio threat detection,” said Mark Wrobel, program manager in DARPA’s Defense Sciences Office. “Collecting chemical and biological environment data provided an enhanced understanding of the urban environment and is helping us make refinements of the threat-detection algorithms to minimize false positives and false negatives.”

SIGMA+ expands on the original SIGMA program’s advanced capability to detect illicit radioactive and nuclear materials by developing new sensors and networks that would alert authorities with high sensitivity to chemical, biological, and explosives threats as well. SIGMA, which began in 2014, has demonstrated city-scale capability for detecting radiological threats and is now operationally deployed with the Port Authority of New York and New Jersey, helping protect the greater New York City region.

What we pay attention to shapes our opinions and views and our opinions and views shape our actions—well beyond clicks and taps on a screen.

But this is only the beginning. The internet and its enabling tools were the last great generation of technology. New generations are already making their presence known. In coming decades, technology will more compellingly seduce our attention, will escape its silicon-and-glass cage, will animate the inanimate, and even shape our biology.

The answer isn’t to do away with technology. There’s no putting the genie back in the bottle—nor should we want to. Besides negative outcomes, technology remains a powerful tool for good too. But as individuals, as a society, we need to become far more aware of how we interact with technology, to keep a closer eye on business incentives, and to consciously employ our tools in ways that firmly align with our goals.

When and how did the first animals appear? Science has long sought an answer to this question. Uppsala University researchers and colleagues in Denmark have now jointly found, in Greenland, embryo-like microfossils up to 570 million years old, revealing that organisms of this type were dispersed throughout the world. The study is published in Communications Biology.

“We believe this discovery of ours improves our scope for understanding the period in Earth’s history when animals first appeared—and is likely to prompt many interesting discussions,” says Sebastian Willman, the study’s first author and a palaeontologist at Uppsala University.

The existence of animals on Earth around 540 million years ago (mya) is well substantiated. This was when the event in evolution known as the “Cambrian Explosion” took place. Fossils from a huge number of creatures from the Cambrian period, many of them shelled, exist. The first animals must have evolved earlier still; but there are divergent views in the research community on whether the extant fossils dating back to the Precambrian Era are genuinely classifiable as animals.

The idea of terraforming Mars is a fascinating idea. … But just how long would such an endeavor take, what would it cost us, and is it really an effective use of our time and energy?

Ultimately, Yakovlev thinks that space biospheres could also be accomplished within a reasonable timeframe – i.e. between 2030 and 2050 – which is simply not possible with terraforming. Citing the growing presence and power of the commercial space sector, Yakovlev also believed a lot of the infrastructure that is necessary is already in place (or under development).

Continue reading “The future of space colonization – terraforming or space habitats?” »

Circa 2011

There is a physical and electrical disconnect between the world of electronics and the world of biology. Electronics tend to be rigid, operate using electrons, and are inherently two-dimensional. The brain, as a basis for comparison, is soft, operates using ions, and is three-dimensional. Researchers have therefore been looking to find different routes to create biocompatible devices that work well in wet environments like biological systems. In an exiting new development, researchers from North Carolina State University have fabricated a memory device that is soft, entirely based on liquid-based matter, and functions well in wet environments — opening the door to a new generation of biocompatible electronic devices.

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

Researchers at the Department of Energy’s Oak Ridge National Laboratory used neutron scattering to identify key information to improve the effectiveness of drug inhibitors designed to block the virus’s replication mechanism. The research is published in the Journal of Biological Chemistry.

The SARS-CoV-2 virus, which causes the COVID-19 disease, expresses long chains of proteins composed of approximately 1,900 amino acid residues. For the virus to reproduce, those chains have to be broken down and cut into smaller strands by an enzyme called the main protease. The active protease enzyme is formed from two identical protein molecules held together by hydrogen bonds. Developing a drug that inhibits or blocks the protease activity will prevent the virus from replicating and spreading to other cells in the body.

The discovery puts a nail in the coffin of a long-held assumption about the limits of where the essential process can occur.