In a discovery three decades in the making, scientists at Rutgers and Brookhaven National Laboratory have acquired detailed knowledge about the internal structures and mode of regulation for a specialized protein and are proceeding to develop tools that can capitalize on its ability to help plants combat a wide range of diseases.
The work, which exploits a natural process where plant cells die on purpose to help the host plant stay healthy, is expected to have wide applications in the agricultural sector, offering new ways to protect major food crops from a variety of devastating diseases, the scientists said.
In a study published in Nature Communications, a team led by Eric Lam at Rutgers University-New Brunswick and Qun Liu at Brookhaven National Laboratory in New York reported that advanced crystallography and computer modeling techniques have enabled them to obtain the best picture yet of a pivotal plant protease, a protein enzyme that cuts other proteins, known as metacaspase 9.