Lifeboat Foundation

The neocortex is the part of the brain that enables us to speak, dream, or think. The underlying mechanism that led to the expansion of this brain region during evolution, however, is not yet understood. A research team headed by Wieland Huttner, director at the Max Planck Institute of Molecular Cell Biology and Genetics, now reports an important finding that paves the way for further research on brain evolution: The researchers analyzed the gyrencephaly index, indicating the degree of cortical folding, of 100 mammalian brains and identified a threshold value that separates mammalian species into two distinct groups: Those above the threshold have highly folded brains, whereas those below it have only slightly folded or unfolded brains. The research team also found that differences in cortical folding did not evolve linearly across species.

The Dresden researchers examined brain sections from more than 100 different mammalian species with regard to the gyrencephaly index, which indicates the degree of folding of the neocortex. The data indicate that a highly folded neocortex is ancestral – the first mammals that appeared more than 200 million years ago had folded brains. Like brain size, the folding of the brain, too, has increased and decreased along the various mammalian lineages. Life-history traits seem to influence this: For instance, mammals with slightly folded or unfolded brains live in rather small social groups in narrow habitats, whereas those with highly folded brains form rather large social groups spreading across wide habitats.

A threshold value of the folding index at 1.5 separates mammalian species into two distinct groups: Dolphins and foxes, for example, are above this threshold value – their brains are highly folded and consist of several billion neurons. This is so because basal progenitors capable of symmetric proliferative divisions are present in the neurogenic program of these animals. In contrast, basal progenitors in mice and manatees lack this proliferative capacity and thus produce less neurons and less folded or unfolded brains.

The cerebral cortex, which controls higher processes such as perception, thought and cognition, is the most complex structure in the mammalian central nervous system. Although much is known about the intricate structure of this brain region, the processes governing its formation remain uncertain. Research led by Carina Hanashima from the RIKEN Center for Developmental Biology has now uncovered how feedback between cells, as well as molecular factors, helps shape cortical development during mouse embryogenesis.

The cortex is made up of layers of interconnecting cells that are produced in a particular order from progenitor cells. The relatively cell-sparse outer layer is formed first, then the dense deep layer, and finally the tightly packed upper layer. Hanashima and her colleagues were interested to discover exactly how the various layers form, so they created a mouse model that enabled them to control the expression of a particular protein, Foxg1, known to be involved in cortical development.

The Foxg1 gene, if switched on toward the end of embryogenesis after the outer layer of neurons has formed, triggers the production of deep-layer neurons, followed by upper-layer neurons (Fig. 1). The researchers found that it does this by repressing the activity of another gene, called Tbr1, in the outer-layer neurons.

A matter-wave interferometer can probe the magnetism of a broad range of species, from single atoms to very large, weakly magnetic molecules.

This year marks the centenary of the ground-breaking experiment of Otto Stern and Walther Gerlach that demonstrated the quantization of the spin angular momentum of an atom [1]. The evidence came from the observation that a beam of silver atoms, upon traversing a spatially varying magnetic field, split into two beams. The spatial splitting of the spin-up and spin-down atoms corresponded to an atomic magnetic moment of 1 Bohr magneton—the magnetic moment of a single spinning electron. The deflection of particle beams in a spatially varying magnetic field remains the basis of techniques for characterizing the magnetic properties of isolated atoms and molecules. Such techniques, however, aren’t sufficiently sensitive to study very large, weakly magnetic molecules, including many biological molecules.

Alcohol Fermentation or ethanol fermentation is a biological method wherein the sugar gets transformed into carbon dioxide and alcohol.

This Video Explains Alcoholic Fermentation.
Ethanol fermentation, also called alcoholic fermentation, is a biological process which converts sugars such as glucose into cellular energy under anaerobic conditions and producing ethanol and carbon dioxide as by-products.
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Circa 2019 The pineal gland is often misunderstood even today we still are glimpsing the vast universe of the human mind but until we can essentially know all input and output of the human brain we may not know everything that is needed for proper care of the human brain much like back in the 1900s when we still talked about aether or even miasma. We can see Manu things like the pineal gland produces dmt, HGH, melatonin, aswell as many other biological functions for circadian rhythm even dreams but still are scratching the surface.

Keywords: autism, pineal gland, N, N-dimethyltryptamine (DMT), melatonin, neural plasticity.

Citation: Shomrat T and Nesher N (2019) Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders. Front. Endocrinol. 10:37. doi: 10.3389/fendo.2019.

Continue reading “Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders” »

face_with_colon_three circa 2018.

Understanding the fundamental constituents of the universe is tough. Making sense of the brain is another challenge entirely. Each cubic millimetre of human brain contains around 4 km of neuronal “wires” carrying millivolt-level signals, connecting innumerable cells that define everything we are and do. The ancient Egyptians already knew that different parts of the brain govern different physical functions, and a couple of centuries have passed since physicians entertained crowds by passing currents through corpses to make them seem alive. But only in recent decades have neuroscientists been able to delve deep into the brain’s circuitry.

On 25 January, speaking to a packed audience in CERN’s Theory department, Vijay Balasubramanian of the University of Pennsylvania described a physicist’s approach to solving the brain. Balasubramanian did his PhD in theoretical particle physics at Princeton University and also worked on the UA1 experiment at CERN’s Super Proton Synchrotron in the 1980s. Today, his research ranges from string theory to theoretical biophysics, where he applies methodologies common in physics to model the neural topography of information processing in the brain.

Continue reading “Particle physics on the brain” »

Humanity has left its mark on the Earth, from cities of steel to mountains of styrofoam. The latter is proving to be a problem, as many of the synthetic materials we produce don’t degrade in anything approaching a human timescale. Scientists have long sought to develop better plastic recycling methods, and the answer might be crawling around in the wild. Researchers from the University of Queensland in Australia say that a beetle larvae (it looks like a worm in larval form) may hold the key to eliminating polystyrene from the environment.

Styrofoam, technically known as polystyrene, is one of the most common types of plastic, accounting for 7–10 percent of all the non-fibrous plastics produced. You probably encounter it frequently in packing materials where the material’s foam conformation is adept at absorbing impacts. The solid version of polystyrene can be used to make transparent containers, disposable utensils, and more. However, polystyrene carries a recycling ID of 6, meaning it’s difficult to process and is not accepted at most curbside pickups.

Scientists have long searched for microbes or insect enzymes that could help break down durable plastics like polystyrene, and a beetle known as Zophobas morio might have it. It’s a species of darkling beetle, and the larval form is more commonly known as a superworm. They look like larger mealworms and are often used as a food source for insectivorous animals. In addition to being a high-protein, low-carb snack, this creature’s gut carries a unique mixture of bacterial enzymes that can digest polystyrene. The researchers reported that darkling beetle larva can subsist entirely on a diet of polystyrene — they can even grow while eating a pile of plastic.

Scientists have shed new light on the timing and likely cause of major volcanic events that occurred millions of years ago and caused such climatic and biological upheaval that they drove some of the most devastating extinction events in Earth’s history.

Surprisingly, the new research, published today in Science Advances, suggests a slowing of continental plate movement was the critical event that enabled magma to rise to the Earth’s surface and deliver the devastating knock-on impacts.

Earth’s history has been marked by major volcanic events, called large igneous provinces (LIPs)—the largest of which have caused major increases in atmospheric carbon emissions that warmed Earth’s climate, drove unprecedented changes to ecosystems, and resulted in mass extinctions on land and in the oceans.

In this video I discuss 5 Types of Compute which can replace our traditional Computers in the Future.

Watch Next:
➞ Analog Compute: https://youtu.be/f4A85foHPZY
➞ Biological Compute: https://youtu.be/FuzoLdrRX5Q
➞ Compute with Light: https://youtu.be/mt8I71VUazw.
➞ Quantum Computers: https://youtu.be/j9eYQ_ggqJk.
➞ RF compute paper: https://www.researchgate.net/publication/345970494_Radio-Fre…c_Synapses.

Continue reading “Future Computers Will Be Entirely Different” »