Lifeboat Foundation

IBM scientists have developed a new lab-on-a-chip technology that can, for the first time, separate biological particles at the nanoscale and could help enable physicians to detect diseases such as cancer before symptoms appear.

As reported today in the journal Nature Nanotechnology*, the IBM team’s results show size-based separation of bioparticles down to 20 nanometers (nm) in diameter, a scale that gives access to important particles such as DNA, viruses and exosomes. Once separated, these particles can be analyzed by physicians to potentially reveal signs of disease even before patients experience any physical symptoms and when the outcome from treatment is most positive. Until now, the smallest bioparticle that could be separated by size with on-chip technologies was about 50 times or larger, for example, separation of circulating tumor cells from other biological components.

IBM is collaborating with a team from the Icahn School of Medicine at Mount Sinai to continue development of this lab-on-a-chip technology and plans to test it on prostate cancer, the most common cancer in men in the U.S.

Continue reading “IBM lab on a chip can sort 20 nanometer nanoparticles such as DNA, viruses and exos” »

It’s the feel good Autopilot story Tesla has been waiting for.

This pill could change treatment for type 2 diabetes forever.

Dr. Aubrey de Grey of the of the SENS Research Foundation explains the OncoSENS approach to curing ALT-Cancer, the corresponding crowdunding campaign (https://www.lifespan.io/campaigns/sens-control-alt-delete-cancer/), and how this is a vital part of overcoming the ill-effects of aging.

This presentation is part of the Designing New Advances conference held by the Institute of Exponential Sciences in the Netherlands, orchestrated by Demian Hoed, and Lotte Van Norte.

Continue reading “Aubrey de Grey Explains SENS Anti-Cancer Strategy and Lifespan.io Campaign at D.N.A. Conference” »

California-based startup Ambrosia is starting clinical trials that will see older people pumped with blood from younger donors, in the hopes of rejuvenating their bodies.

Reversing and eliminating aging has always been one of the true Holy Grails of medical science. Like the search for the rumored Grail, the journey to eliminate aging will be a difficult one– and there is some doubt as to whether it is actually achievable.

Continue reading “Reversing Aging: Clinical Trials For ‘Young-to-Old’ Blood Transfusions Begin” »

Open Bionics prosthetic arm.

We’re live with Open Bionics and we’re checking out their insanely cool Deus Ex prosthetic arm.

More progress with senolytics for treating age related diseases and further vindication for the SENS approach to aging.

The open access paper linked below provides another reason to be optimistic about the therapies to clear senescent cells from old tissues that are presently under development. Here, the researchers created genetically engineered mice in which they could selectively trigger senescent cell death in lung tissues. In older mice, the result was improved pulmonary function, and other improvements in the state of lung tissue — turning back the clock on some of the detrimental age-related changes that take place in the lungs.

Cells become senescent in response to damage or environmental toxicity, or at the end of their replicative lifespan, or to assist in wound healing. The vast majority either destroy themselves or are destroyed by the immune system, but a few manage to linger on. Those few grow in numbers over the years, and more so once the immune system begins to decline and falter in its duties. Ever more senescent cells accumulate in tissues with advancing age, and they secrete a mix of signals that can encourage other cells to become senescent, increase inflammation, and destructively remodel nearby tissue structures. In small numbers senescent cells can help to resist cancer or assist healing, but in large numbers they contribute meaningfully to all of the symptoms and conditions of old age. They are one of the root causes of aging.

Continue reading “Removing Senescent Cells from the Lungs of Old Mice Improves Pulmonary Function and Reduces Age-Related Loss of Tissue Elasticity” »

Posting for the friends who hasn’t heard about the US funding the new program to grow half human and half animal embryos. Part of the goal is to enable organs to be made available for transplants, etc…

The federal government is planning to lift a moratorium on funding of controversial experiments that use human stem cells to create animal embryos that are partly human.

The National Institutes of Health has unveiled a new policy to permit scientists to get federal money to make the embryos, known as chimeras, under certain carefully monitored conditions.

Continue reading “US Government gives go-ahead to research to grow part-animal part-human organs for transplants” »

The benefits of the technology for humans, while still largely hypothetical, are promising. The sensors could allow physicians to monitor the health of organs, create new therapies for neurological disorders, and help the physically impaired to control prosthetics.

While chips have been implanted in humans and other animals before, these sensors mark a significant improvement because they are small, wireless, batteryless, and could last in the body for years without degrading, said Michel Maharbiz, the associate professor who devised and studied the sensors alongside neuroscientist Jose Carmena.

“Hopefully the [tiny sensors] demonstrate a new direction for the field, and then you could build the consensus that’s needed to drive these forward,” Maharbiz said.

Continue reading “Engineers implanted tiny sensors in rats’ nerves and muscles. Are humans next?” »