Lifeboat Foundation

As an embryo grows, there is a continuous stream of communication between cells to form tissues and organs. Cells need to read numerous cues from their environment, and these may be chemical or mechanical in nature. However, these alone cannot explain collective cell migration, and a large body of evidence suggests that movement may also happen in response to embryonic electrical fields. How and where these fields are established within embryos was unclear until now.

“We have characterized an endogenous bioelectric current pattern, which resembles an electric field during development, and demonstrated that this current can guide migration of a cell population known as the neural crest,” highlights Dr. Elias H. Barriga, the corresponding author who led the study published in Nature Materials.

Initially, Dr. Barriga and his team began research on the neural crest at the former Gulbenkian Institute of Science (IGC) in Oeiras, Portugal before continuing research in Dresden, establishing a group at the Cluster of Excellence Physics of Life.

Our genes contain all the instructions our body needs to function, but their expression must be finely regulated to guarantee that each cell performs its role optimally. This is where DNA and RNA epigenetics come in: a series of mechanisms that act as “markers” on genes, to control their activity without modifying the DNA or RNA sequence itself.

Until now, DNA and RNA epigenetics were studied as independent systems. These two mechanisms seemed to function separately, each playing its own role in distinct stages of the gene regulation process.

Perhaps that was a mistake.

In the final report of a phase 1 trial evaluating intracerebroventricular B7-H3-targeting CAR T cells in children and young adults with diffuse intrinsic pontine glioma, repeated intracranial infusions were feasible and well tolerated with a median overall survival of 19.8 months and 3 patients surviving over 40 months from diagnosis.

As the rate of humanity’s data creation increases exponentially with the rise of AI, scientists have been interested in DNA as a way to store digital information. After all, DNA is nature’s way of storing data. It encodes genetic information and determines the blueprint of every living thing on earth.

And DNA is at least 1,000 times more compact than solid-state hard drives. To demonstrate just how compact, researchers have previously encoded all of Shakespeare’s 154 sonnets, 52 pages of Mozart’s music, and an episode of the Netflix show “Biohackers” into tiny amounts of DNA.

Continue reading “An Entire Book Was Written in DNA—and You Can Buy It for $60” »

What is cell senescence and inflammaging?

Featuring Matt Yousefzadeh, PhD

Continue reading “What Is Cell Senescence And Inflammaging? Matt Yousefzadeh, PhD” »

Large language models surpass human experts in predicting neuroscience results, according to a study published in Nature Human Behaviour.

Scientific research is increasingly challenging due to the immense growth in published literature. Integrating noisy and voluminous findings to predict outcomes often exceeds human capacity. This investigation was motivated by the growing role of artificial intelligence in tasks such as protein folding and drug discovery, raising the question of whether LLMs could similarly enhance fields like neuroscience.

Xiaoliang Luo and colleagues developed BrainBench, a benchmark designed to test whether LLMs could predict the results of neuroscience studies more accurately than human experts. BrainBench included 200 test cases based on neuroscience research abstracts. Each test case consisted of two versions of the same abstract: one was the original, and the other had a modified result that changed the study’s conclusion but kept the rest of the abstract coherent. Participants—both LLMs and human experts—were tasked with identifying which version was correct.

Polygenic scores (PGS) are metrics used to estimate the genetic predisposition of people to developing specific mental health conditions, personality traits or diseases. In recent years, these metrics have often been used to investigate the intricate connections between genes and environmental factors.

Researchers at the JJ Peters VA Medical Center, Icahn School of Medicine at Mount Sinai and other institutes recently carried out a study aimed at determining whether neuropsychiatric polygenic scores could predict the professional categories that individuals belong to. Their findings, published in Nature Human Behaviour, suggest that these scores weakly predict the professional category that people belong to.

“Neuropsychiatric disorders are both common and highly heritable, yet they remain heavily stigmatized,” Georgios Voloudakis, first author of the paper, told Medical Xpress.

For the first time ever, scientists have used a technique called “quantum squeezing” to improve the gas sensing performance of devices known as optical frequency comb lasers. These ultra-precise sensors are like fingerprint scanners for molecules of gas. Scientists have used them to spot methane leaks in the air above oil and gas operations and signs of COVID-19 infections in breath samples from humans.

Now, in a series of lab experiments, researchers have laid out a path for making those kinds of measurements even more sensitive and faster—doubling the speed of frequency comb detectors. The work is a collaboration between Scott Diddams at CU Boulder Boulder and Jérôme Genest at Université Laval in Canada.

“Say you were in a situation where you needed to detect minute quantities of a dangerous gas leak in a factory setting,” said Diddams, professor in the Department of Electrical, Computer and Energy Engineering. “Requiring only 10 minutes versus 20 minutes can make a big difference in keeping people safe.”

Scientists develop DNADNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA). tabindex=0 DNA nanorobots capable of modifying artificial cells.