Could a fecal transplant pill be the antidepressants of the future?
Depression is real, and it is complex. Most conditions that affect our brain chemistry are going to be complex, and there are no easy, simple answers. We can’t cure depression by just exercising more, eating better, or taking a short vacation to recharge (although there is some evidence that getting more money, especially to lift you out of poverty, helps relieve depressive symptoms).
Micrometeorites, tiny space rocks, may have helped deliver nitrogen, a vital life ingredient, to Earth during our solar system’s early days. This finding was published in Nature Astronomy on November 30 by an international research team, including scientists from the University of Hawaiʻi at Mānoa and Kyoto University. They discovered that nitrogen compounds like ammonium salts are common in material from regions distant from the sun. However, how these compounds reached Earth’s orbit was unclear.
The study suggests that more nitrogen compounds were transported near Earth than previously thought. These compounds could have contributed to life on our planet. The research was based on material collected from the asteroid Ryugu by Japan’s Hayabusa2 spacecraft in 2020. Ryugu, a small sun-orbiting rocky object, is carbon-rich and has experienced considerable space weathering due to micrometeorite impacts and solar charged ions.
The scientists studied the Ryugu samples to understand the materials reaching Earth’s orbit. They used an electron microscope and found the Ryugu samples’ surface covered with tiny iron and nitrogen minerals. They theorized that micrometeorites carrying ammonia compounds collided with Ryugu. This collision sparked chemical reactions on magnetite, resulting in iron nitride formation.
When Emiliano Cortés goes hunting for sunlight, he doesn’t use gigantic mirrors or sprawling solar farms. Quite the contrary, the professor of experimental physics and energy conversion at LMU dives into the nanocosmos.
“Where the high-energy particles of sunlight, the photons, meet atomic structures is where our research begins,” Cortés says. “We are working on material solutions to capture and use solar energy more efficiently.”
His findings have great potential as they enable novel solar cells and photocatalysts. The industry has high hopes for the latter because they can make light energy accessible for chemical reactions—bypassing the need to generate electricity. But there is one major challenge to using sunlight, which solar cells also have to contend with, Cortés knows: “Sunlight arrives on Earth ‘diluted,’ so the energy per area is comparatively low.” Solar panels compensate for this by covering large areas.
Summary: Dopamine, a neurotransmitter, plays a vital role in encoding both reward and punishment prediction errors in the human brain.
This study suggests that dopamine is essential for learning from both positive and negative experiences, enabling the brain to adapt behavior based on outcomes. Using electrochemical techniques and machine learning, scientists measured dopamine levels in real-time during a computer game involving rewards and penalties.
The findings shed light on the intricate role of dopamine in human behavior and could have implications for understanding psychiatric and neurological disorders.
Pentoses are essential carbohydrates in the metabolism of modern lifeforms, but their availability during early Earth is unclear since these molecules are unstable.
A new study, published in the journal JACS Au and led by the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology, Japan, reveals a chemical pathway compatible with early Earth conditions and by which C6 aldonates could have acted as a source of pentoses without the need for enzymes. Their findings provide clues about primitive biochemistry and bring us closer to understanding the Origins of Life.
The emergence of life on Earth from simple chemicals is one of the most exciting yet challenging topics in biochemistry and perhaps all of science. Modern lifeforms can transform nutrients into all sorts of compounds through complex chemical networks; what’s more, they can catalyze very specific transformations using enzymes, achieving a very fine control over what molecules are produced.
It really is impressive how many unknowns there are about the next decade in transportation. Sure, there have always been innovations and surprises, but to be unsure what most vehicles will even be powered by in 10 years, nor who — or what — will be in the driver’s seat, is astounding. Battery-electric vehicles are the leading contender to usurp internal combustion, eventually, though the road to that outcome is full of hurdles. Solid-state batteries (SSB) are seen as one of the key innovations to get there, various makers saying they’ll have at least one product with a solid-state battery on the market by the end of the decade. The overall numbers of SSB-powered vehicles might remain surprisingly low well into the 2030s, though. In Toyota’s internal news outlet, Toyota Times, the automaker wrote, “In the [SSB] mass production phase anticipated for 2030 and beyond, the companies are looking to boost capacity to several thousand tonnes (several tens of thousands of vehicles) in line with Toyota’s product plans.”
The “companies” referred to are Toyota and Japan’s petrochemical conglomerate Idemitsu Kosan, which formalized collaboration on SSBs this year. Right now, Toyota and Idemitsu are working on the development times for solid electrolyte and resulting quality and cost. When those are locked in, the firms will work on a pilot facility for commercialization. Initial commercial effort will take two years of testing and validation before wider production commences in 2030.
The “several tens of thousands of vehicles” appears to have gone through at least one revision after publication. In Jalopnik’s writeup, the capacity was quoted as “over ten thousand vehicles.” Even at the larger sum, that’s considerably less than onlookers expected, but that might be because onlookers expected too much, not because Toyota overpromised. The automaker’s talked big numbers for BEV sales, but has talked just as bigly about what kinds of electrified powertrains those sales will entail: At least four kinds of battery technologies, plus hydrogen, and hybrids. In 2021, Toyota said it expected to have an SSB ready by 2025. In 2022, a Toyota engineer said the first product to get an SSB would be a hybrid on go on sale in the first half of the decade.
Similar to human teenagers, teenage galaxies are awkward, experience growth spurts and enjoy heavy metal — nickel, that is.
A Northwestern University-led team of astrophysicists has just analyzed the first results from the CECILIA (Chemical Evolution Constrained using Ionized Lines in Interstellar Aurorae) Survey, a program that uses NASA’s James Webb Space Telescope (JWST) to study the chemistry of distant galaxies.
According to the early results, so-called “teenage galaxies” — which formed two-to-three billion years after the Big Bang — are unusually hot and contain unexpected elements, like nickel, which are notoriously difficult to observe.
Skoltech scientists have found a way to improve the most widely used technology for producing single-walled carbon nanotube films—a promising material for solar cells, LEDs, flexible and transparent electronics, smart textiles, medical imaging, toxic gas detectors, filtration systems, and more. By adding hydrogen gas along with carbon monoxide to the reaction chamber, the team managed to almost triple carbon nanotube yield compared with when other growth promoters are used, without compromising quality.
Until now, low yield has been the bottleneck limiting the potential of that manufacturing technology, otherwise known for high product quality. The study has been published in the Chemical Engineering Journal.
Although that is not how they’re really made, conceptually, nanotubes are a form of carbon where sheets of atoms in a honeycomb arrangement—known as graphene—are seamlessly rolled into hollow cylinders.
Over centuries of painstaking laboratory work, chemists have synthesized several hundred thousand inorganic compounds — generally speaking, materials not based on the chains of carbon atoms that are characteristic of organic chemistry. Yet studies suggest that billions of relatively simple inorganic materials are still waiting to be discovered3. So where to start looking?
Many projects have tried to cut down on time spent in the lab tinkering with various materials by computationally simulating new inorganic materials and calculating properties such as how their atoms would pack together in a crystal. These efforts — including the Materials Project based at the Lawrence Berkeley National Laboratory (LBNL) in Berkeley, California — have collectively come up with about 48,000 materials that they predict will be stable.
Google DeepMind has now supersized this approach with an AI system called graph networks for materials exploration (GNoME). After training on data scraped from the Materials Project and similar databases, GNoME tweaked the composition of known materials to come up with 2.2 million potential compounds. After calculating whether these materials would be stable, and predicting their crystal structures, the system produced a final tally of 381,000 new inorganic compounds to add to the Materials Project database1.
Electrocatalysis expands the ability to generate industrially relevant chemicals locally and on-demand with intermittent renewable energy, thereby improving grid resiliency and reducing supply logistics. Herein, we report the feasibility of using molecular copper boron-imidazolate cages, BIF-29(Cu), to enable coupling between the electroreduction reaction of CO2 (CO2RR) with NO3– reduction (NO3RR) to produce urea with high selectivity of 68.5% and activity of 424 μA cm–2. Remarkably, BIF-29(Cu) is among the most selective systems for this multistep C–N coupling to-date, despite possessing isolated single-metal sites. The mechanism for C–N bond formation was probed with a combination of electrochemical analysis, in situ spectroscopy, and atomic-scale simulations. We found that NO3RR and CO2RR occur in tandem at separate copper sites with the most favorable C–N coupling pathway following the condensation between *CO and NH2OH to produce urea. This work highlights the utility of supramolecular metal–organic cages with atomically discrete active sites to enable highly efficient coupling reactions.