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Archive for the ‘chemistry’ category: Page 162

Jan 3, 2023

Artificial DNA can kill cancer

Posted by in categories: biotech/medical, chemistry

𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 𝐚𝐭 𝐭𝐡𝐞 𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲 𝐨𝐟 𝐓𝐨𝐤𝐲𝐨 𝐢𝐧 𝐉𝐚𝐩𝐚𝐧 𝐡𝐚𝐯𝐞 𝐮𝐬𝐞𝐝 𝐚𝐫𝐭𝐢𝐟𝐢𝐜𝐢𝐚𝐥 𝐃𝐍𝐀 𝐭𝐨 𝐭𝐚𝐫𝐠𝐞𝐭 𝐚𝐧𝐝 𝐤𝐢𝐥𝐥 𝐜𝐚𝐧𝐜𝐞𝐫 𝐜𝐞𝐥𝐥𝐬 𝐢𝐧 𝐚 𝐧𝐞𝐰 𝐰𝐚𝐲.

The method was effective in lab tests against human cervical cancer-and breast cancer-derived cells, and against malignant melanoma cells from mice. The team created a pair of chemically synthesized, hairpin-shaped, cancer-killing DNA. When the DNA pairs were injected into cancer cells, they connected to microRNA (miRNA) molecules that are overproduced in certain cancers.

Once connected to the miRNA, they unraveled and joined together, forming longer chains of DNA which triggered an immune response. This response not only killed the cancer cells but prevented further growth of cancerous tissue. This method is different from conventional anticancer drug treatments and is hoped to bring about a new era of drug development.

Jan 2, 2023

Solar-powered cells: Light-activated proton pumps generate cellular energy, extend life

Posted by in categories: bioengineering, biotech/medical, chemistry, genetics, life extension

New research in the journal Nature Aging takes a page from the field of renewable energy and shows that genetically engineered mitochondria can convert light energy into chemical energy that cells can use, ultimately extending the life of the roundworm C. elegans. While the prospect of sunlight-charged cells in humans is more science fiction than science, the findings shed light on important mechanisms in the aging process.

“We know that is a consequence of aging,” said Andrew Wojtovich, Ph.D., associate professor of Anesthesiology and Perioperative Medicine and Pharmacology & Physiology at the University of Rochester Medical Center and senior author of the study.

“This study found that simply boosting metabolism using light-powered gave laboratory worms longer, healthier lives. These findings and new research tools will enable us to further study mitochondria and identify new ways to treat age-related diseases and age healthier.”

Jan 2, 2023

Biomaterial Design Inspired by Regenerative Research Organisms

Posted by in category: chemistry

The efficacy of implanted biomaterials is largely dependent on the response of the host’s immune and stromal cells. Severe foreign body response (FBR) can impede the integration of the implant into the host tissue and compromise the intended mechanical and biochemical function. Many features of FBR, including late-stage fibrotic encapsulation of implants, parallel the formation of fibrotic scar tissue after tissue injury. Regenerative organisms like zebrafish and salamanders can avoid fibrosis after injury entirely, but FBR in these research organisms is rarely investigated because their immune competence is much lower than humans. The recent characterization of a regenerative mammal, the spiny mouse (Acomys), has inspired us to take a closer look at cellular regulation in regenerative organisms across the animal kingdom for insights into avoiding FBR in humans.

Jan 1, 2023

Microscopic Animal Brought Back To Life After 24,000 Years Frozen In Siberian Permafrost

Posted by in categories: biological, chemistry, life extension

Tardigrades have competition in the realm of microscopic and incredibly sturdy beasties. Like tardigrades, Bdelloid rotifers can also survive drying, freezing, starving, and even low-oxygen conditions. Now, scientists report that they revived some of these rotifers after having been frozen in Siberian permafrost for at least 24,000 years.

The incredible observations are reported in the journal Current Biology. The researchers took samples of permafrost about 3.5 meters (11.5 feet) deep and slowly warmed the sample, which led to the resurrection of several microscopic organisms including these tiny little animals.

“Our report is the hardest proof as of today that multicellular animals could withstand tens of thousands of years in cryptobiosis, the state of almost completely arrested metabolism,” co-author Stas Malavin of the Soil Cryology Laboratory at the Institute of Physicochemical and Biological Problems in Soil Science in Pushchino, Russia, said in a statement.

Jan 1, 2023

Graphene-Based Electronics: Can This Replace Silicon Microelectronics, Semiconductors?

Posted by in categories: chemistry, materials

Finding a material that could replace silicon is a critical task in nanoelectronics. For many years, graphene has appeared promising. However, its potential was compromised along the way because of destructive processing techniques and the absence of a new electronics paradigm to adopt it. The need for the next major nanoelectronics platform is greater than ever, as silicon is almost at its limit in supporting faster computation.

The strength of graphene, according to Walter de Heer, a professor at the Georgia Institute of Technology’s School of Physics, rests in its flat, two-dimensional structure, which is kept together by the strongest chemical bonds known.

Dec 31, 2022

Trillions of tiny, self-replicating satellites could unlock interstellar travel

Posted by in categories: biological, chemistry, genetics, satellites

Alpha Centauri, here we come.


However, while technology has indeed advanced a long way since the 1940s, it still seems like we are still a long way from having a fully functional von Neumann machine. That is unless you turn to biology. Even simple biological systems can perform absolutely mind-blowing feats of chemical synthesis. And there are few people in the world today who know that better than George Church. The geneticist from Harvard has been at the forefront of a revolution in the biological sciences over the last 30 years. Now, he’s published a new paper in Astrobiology musing about how biology could aid in creating a pico-scale system that could potentially explore other star systems at next to no cost.

Continue reading “Trillions of tiny, self-replicating satellites could unlock interstellar travel” »

Dec 31, 2022

What Happens To 3D-Printed Materials When They Get Older?

Posted by in categories: 3D printing, chemistry, life extension

3D printers to create rapid on-demand objects have only been around for a short time. It’s a popular technique for making quick mock-ups or temporary solutions, but 3D-printing can also be used for more long-term applications. For example, some museums used it to create tactile models for interactive displays or even to create structural parts to support restoration projects. Either way, these are not temporary whimsical creations, but structures that they would likely still want to be in perfect shape several years down the line.

There are also other reasons to want to preserve 3D-printed materials for more than just a few years, but we haven’t had the technology for long enough to really know what will happen to these objects over time.

To find out, art conservation researchers at the Universidad Complutense de Madrid in Spain subjected two types of 3D printing materials to an artificial accelerated aging process. When plastics age, any damage such as loss of color or chemical changes in the materials are often caused either by UV radiation from exposure to light or by extreme temperature fluctuations. To simulate these extreme environments in a much faster scale than natural aging, the researchers put the 3D printed samples and the original filaments in two different chambers: One exposing the samples to UV light and the other subjecting them to a range of high temperatures.

Dec 31, 2022

Old Christmas trees could be recycled into renewable fuels and other useful products

Posted by in categories: chemistry, energy

Turns out, sending millions to the landfills need not be the case.

A new study is finding that pine needles from discarded Christmas trees could be used to produce renewable fuels and value-added chemicals using only water as a solvent, according to a press release by the University of Sheffield published on Thursday.

Releasing dangerous methane gas.

Dec 31, 2022

Neural control of monkeys’ body temperatures could be useful for space travel

Posted by in categories: chemistry, food, space

The study aims to induce hibernation in monkeys and, eventually, in humans.

In a new study, researchers reduced the core body temperature of crab-eating macaques purely by controlling their brains. The study aims to find a way to induce hibernation in monkeys and, eventually, in humans.


Gremlin/iStock.

Continue reading “Neural control of monkeys’ body temperatures could be useful for space travel” »

Dec 31, 2022

Ultrathin organic solar cells could turn buildings into power generators

Posted by in categories: chemistry, particle physics, solar power, space, sustainability

In November 2021, while the municipal utility in Marburg, Germany, was performing scheduled maintenance on a hot water storage facility, engineers glued 18 solar panels to the outside of the main 10-meter-high cylindrical tank. It’s not the typical home for solar panels, most of which are flat, rigid silicon and glass rectangles arrayed on rooftops or in solar parks. The Marburg facility’s panels, by contrast, are ultrathin organic films made by Heliatek, a German solar company. In the past few years, Heliatek has mounted its flexible panels on the sides of office towers, the curved roofs of bus stops, and even the cylindrical shaft of an 80-meter-tall windmill. The goal: expanding solar power’s reach beyond flat land. “There is a huge market where classical photovoltaics do not work,” says Jan Birnstock, Heliatek’s chief technical officer.

Organic photovoltaics (OPVs) such as Heliatek’s are more than 10 times lighter than silicon panels and in some cases cost just half as much to produce. Some are even transparent, which has architects envisioning solar panels not just on rooftops, but incorporated into building facades, windows, and even indoor spaces. “We want to change every building into an electricity-generating building,” Birnstock says.

Heliatek’s panels are among the few OPVs in practical use, and they convert about 9% of the energy in sunlight to electricity. But in recent years, researchers around the globe have come up with new materials and designs that, in small, labmade prototypes, have reached efficiencies of nearly 20%, approaching silicon and alternative inorganic thin-film solar cells, such as those made from a mix of copper, indium, gallium, and selenium (CIGS). Unlike silicon crystals and CIGS, where researchers are mostly limited to the few chemical options nature gives them, OPVs allow them to tweak bonds, rearrange atoms, and mix in elements from across the periodic table. Those changes represent knobs chemists can adjust to improve their materials’ ability to absorb sunlight, conduct charges, and resist degradation. OPVs still fall short on those measures. But, “There is an enormous white space for exploration,” says Stephen Forrest, an OPV chemist at the University of Michigan, Ann Arbor.