Circa 2015
Researchers have taken a regular gel pen and turned it into a DIY chemical sensor.
Category: chemistry – Page 255
Summary: Researchers identified a genetic correlation between blood biomarkers and a range of mental health disorders. The study provides evidence some substance measures within the blood may be involved in the cause of mental illnesses. For example, immune system proteins may be involved in the development of depression, schizophrenia, and anorexia.
Source: The Conversation.
Mental health disorders including depression, schizophrenia, and anorexia show links to biological markers detected in routine blood tests, according to our new study of genetic, biochemical and psychiatric data from almost a million people.
Milling rice to separate the grain from the husks produces about 100 million tons of rice husk waste globally each year. Scientists searching for a scalable method to fabricate quantum dots have developed a way to recycle rice husks to create the first silicon quantum dot (QD) LED light. Their new method transforms agricultural waste into state-of-the-art light-emitting diodes in a low-cost, environmentally friendly way.
The research team from the Natural Science Center for Basic Research and Development, Hiroshima University, published their findings on January 28, 2022, in the American Chemical Society journal ACS Sustainable Chemistry & Engineering.
“Since typical QDs often involve toxic material, such as cadmium, lead, or other heavy metals, environmental concerns have been frequently deliberated when using nanomaterials. Our proposed process and fabrication method for QDs minimizes these concerns,” said Ken-ichi Saitow, lead study author and a professor of chemistry at Hiroshima University.
Despite being widely used in numerous catalytic applications, our understanding of reactive surface sites of high-surface-area γ-Al2O3 remains limited to date. Recent contributions have pointed toward the potential role of highly reactive edge sites contained in the high-field signal (−0.5 to 0 ppm) of the 1H NMR spectrum of γ-Al2O3 materials. This work combines the development of well-defined, needle-shaped γ-Al2O3 nanocrystals having a high relative fraction of edge sites with the use of state-of-the-art solid-state NMR to significantly deepen our understanding of this specific signal. We are able to resolve two hydroxyl sites with distinct isotropic chemical shifts of −0.2 and −0.4 ppm and different positions within the dipole–dipole network from 1H–1H single-quantum double-quantum NMR.
Chemical biology professor, Suyang Xu, works to crack the secrets of new states of matter.
Throughout human history, most of our efforts to store information, from knots and oracle bones to bamboo markings and the written word, boil down to two techniques: using characters or shapes to represent information. Today, huge amounts of information are stored on silicon wafers with zeros and ones, but a new material at the border of quantum chemistry and quantum physics could enable vast improvements in storage.
Suyang Xu, assistant professor of chemical biology, is tying quantum mechanical “knots” in topological materials, which may be the key to unlocking the potential of quantum technologies to store and process vast arrays of information and bring game-changing advances in a variety of fields.
“Imagine a rope identified by a number of knots,” Xu said. “No matter how much the shape of the rope is changed, the number of knots — known as the topological number — cannot be changed without altering its fundamental identity by adding or undoing knots.” It is this robustness that potentially makes topological materials particularly useful.
A new supplement that stimulates a natural body process also promotes muscle recovery in humans. New research indicates that urolithin A can play an important role in improving muscles and prolonging activity – this is especially important as muscles decline with age, exposing us to the dangers of frailty.
Longevity. Technology sponsored content: As fast as we are unlocking the secrets of urolithin A we are also discovering obstacles. Urolithin A boosts mitochondrial and muscle function for sure, but it’s a metabolite, meaning it is made by the body from raw materials that we get from fruits, especially pomegranates; however, not everyone can make sufficient quantities of this antiaging molecule, and that’s where Mitopure steps in.
It seems to be universally accepted that the older we get, the more easily we get tired and the less energy we have – but perhaps it doesn’t have to be this way. The secret lies in our mitochondria, tiny organelles that pack a mighty punch when it comes to energy production. These minute powerhouses take oxygen and glucose and create a chemical called adenosine triphosphate (ATP) and this is the energy our bodies use for movement, growth and repair.
We produce more than 380 million tonnes of plastic every year, with over 8 million tons of plastic waste escaping into our oceans. Scientists have come up with a creative solution to address this growing plastic problem, and the best thing is that their solution smells and tastes divine.
By getting help from a genetically modified bacteria, a team of researchers at the University of Edinburgh was able to turn plastic bottles into vanilla flavoring. This is the first time a valuable chemical has been achieved from plastic waste.
The study, published in the journal Green Chemistry, explains how bacteria may be used to transform plastic into vanillin, a compound that is used not just in food, but also in cosmetics and pharmaceuticals.
Chemical engineers and materials scientists are continuously looking for the following groundbreaking material, chemical, or medication. The emergence of machine-learning technologies has accelerated the discovery process, which may typically take years. Ideally, the objective is to train a machine-learning model on a few known chemical samples and then let it build as many manufacturable molecules of the same class with predictable physical attributes as feasible. You can develop new molecules with ideal characteristics if you have all of these components and the know-how to synthesize them.
However, current approaches need large datasets for training models. Many class-specific chemical databases only contain a few example compounds, restricting their capacity to generalize and construct biological molecules that might be generated in the real world.
This issue was addressed by a team of researchers from MIT and IBM by employing a generative graph model to create new synthesizable compounds within the same training data’s chemical class. The research was presented in a research paper. They model the production of atoms and chemical bonds as a graph and create a graph grammar — a linguistic analog of systems and structures for word ordering — that provides a set of rules for constructing compounds like monomers and polymers.
The researchers looked at multiple measures of cellular age. First, they used the epigenetic clock, where chemical tags throughout the genome indicate age. Secondly, they looked at the transcriptome, all the gene readouts produced by the cell. By these two measures, the reprogrammed cells matched the profile of cells that were 30 years younger, compared to reference data sets. In other words, cells from a woman of 53 now appeared like those of a woman aged 23.
The potential applications of this technique are dependent on cells not only appearing younger, but functioning like young cells too. Fibroblasts produce collagen – a molecule found in bones, skin tendons, and ligaments, helping provide structure to tissues and heal wounds. In this study, the rejuvenated fibroblasts produced more collagen proteins compared to control cells that did not undergo the reprogramming process. Fibroblasts also move into areas that need repairing. Researchers tested the partially rejuvenated cells by creating an artificial cut in a layer of cells in a dish, seen in the video below. The treated fibroblasts moved into the gap faster than older cells. This is a promising sign that one day this research could eventually be used to create cells that are better at healing wounds.
In the future, this research may also open up other therapeutic possibilities; the researchers observed that their method also influenced other genes linked to age-related diseases and symptoms. The APBA2 gene – associated with Alzheimer’s, and the MAF gene with a role in the development of cataracts – both showed changes towards youthful levels of transcription.
Coming off multiple country approvals for his “patent free” Covid vaccine, Scientist, Researcher, Author, Science Explainer, Dr. Peter Hotez, MD, Ph.D. Baylor College of Medicine, drops by for an episode of Progress, Potential, And Possibilities.
Dr. Peter J. Hotez, M.D., Ph.D. (https://peterhotez.org/), is Dean of the National School of Tropical Medicine and Professor of Pediatrics and Molecular Virology and Microbiology at Baylor College of Medicine (https://www.bcm.edu/people-search/peter-hotez-23229), where he is also Chief of the Section of Pediatric Tropical Medicine and the Texas Children’s Hospital Endowed Chair of Tropical Pediatrics (https://www.texaschildrens.org/find-a-doctor/peter-jay-hotez-md-phd).
Dr. Hotez is also Rice University’s Baker Institute fellow in disease and poverty (https://www.bakerinstitute.org/experts/peter-j-hotez/) and Co-Director of Parasites Without Borders (https://parasiteswithoutborders.com/), a global nonprofit organization with a focus on those suffering from parasitic diseases in subtropical environments.
Dr. Hotez is an internationally recognized physician-scientist with expertise in neglected tropical diseases and vaccine development. He leads the only product development partnership for developing new vaccines for hookworm, schistosomiasis and Chagas disease, and is just coming off a major win for emergency use approval of his team’s Corbevax protein sub-unit COVID-19 vaccine, of which he, and previous guest to the show, Dr. Maria Elena Bottazzi, were recently nominated for a Nobel Prize.
Dr. Hotez is the author of more than 400 original papers, as well as the books Forgotten People, Forgotten Diseases — The Neglected Tropical Diseases and Their Impact on Global Health and Development, Blue Marble Health — An Innovative Plan to Fight Diseases of the Poor amid Wealth, Vaccines Did Not Cause Rachel’s Autism: My Journey as a Vaccine Scientist, Pediatrician, and Autism Dad, and Preventing the Next Pandemic: Vaccine Diplomacy in a Time of Anti-science.