Lifeboat Foundation

A team of scientists, led by Natural History Museum postdoctoral researcher Dr. Anne-Claire Fabre, have conducted the first study on how metamorphosis has influenced the evolution of salamanders.

Using micro-CT scanning to study the skulls of this group of animals, the team were able to build a huge dataset of 148 species of salamanders and used cutting-edge methods to describe the shape of the skull with nearly 1000 reference points, known as landmarks.

Dr. Fabre said, “Most studies of this kind are limited to just a few dozen landmarks. Our study is the first large-scale investigation of this incredibly diverse group. We have captured the shape of the skull in such great detail that it has allowed us to learn more than ever before about how these creatures evolved.”

Not even the lawyers will be spared.

In the summer of 2015, Stanford-bound high school grad Josh Browder spent his nights coding and developing an automated program that would help people contest parking tickets. The native Londoner had recently gotten his driver’s license, and had himself assembled a respectable collection of fines, some of which he felt were unjustly rewarded.

About three weeks later, Browder already had a product called DoNotPay which he shared with his friends. A blogger from Reddit picked up on it, and almost overnight, DoNotPay went from 10 people using it to 50,000 users.

Continue reading “Stanford Grad Who Created The World’s First ‘Robot Lawyer’ Raises $12 Million In Series A” »

A pair of researchers at University College London has found that people with low socioeconomic status experience more declines in age-related functions as they grow older than do people who have a higher socioeconomic status. In their paper published in Proceedings of the National Academy of Sciences, Andrew Steptoe and Paola Zaninotto describe their study of data from the English Longitudinal Study of Ageing, and what they learned.

Prior research has shown that poor people tend to suffer more adverse health effects than those who are better off. They also tend to die younger. But one area of aging that has not been well-studied is the impact of poverty on age-related functional decline, associated with such symptoms as loss of hearing or muscle strength. To learn more about the relationship between socioeconomic status and age-related functional decline, the researchers analyzed data in the English Longitudinal Study of Ageing—an ongoing long-term study of the aging process. Launched in 2002, the study involved collecting data on volunteers aged 50 and over as they grew older. The data includes both medical and physical information, along with test results designed to measure cognitive and emotional levels. The data sample for this new effort included information on 5,018 people 52 years of age or older as they aged over periods of six to eight years.

The researchers found that people living at the lower end of the economic spectrum performed worse on every measure of age-related functionality. Those less well-off lost grip strength, lung function, gait speed, processing speed and executive function. They also tended to report enjoying life less than those who were more affluent. The researchers noted their findings were independent of race, gender, education or age. They also found that those of lesser means experienced more vision problems and were more likely to be depressed.

Good talk, not just about NAD. Q&A just before 35 minutes. A lot of epigenetics here.

David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. His research has been primarily focused on the sirtuins, protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. The Sinclair lab was the first one to identify a role for NAD+ biosynthesis in regulation of lifespan and first showed that sirtuins are involved in CR in mammals. They first identified small molecules that activate SIRT1 such as resveratrol and studied how they improve metabolic function using a combination of genetic, enzymological, biophysical and pharmacological approaches. They recently showed that natural and synthetic activators require SIRT1 to mediate the in vivo effects in muscle and identified a structured activation domain. They demonstrated that miscommunication between the mitochondrial and nuclear genomes is a cause of age-related physiological decline and that relocalization of chromatin factors in response to DNA breaks may be a cause of aging.

The job market of tomorrow will require people to develop their technical capacity in tandem with human-only skills.

The coronavirus pandemic has been a real learning curve, not least for educators. But with many schools now reopening, questions are being asked about what the future of education might look like. CNBC Make It’s Karen Gilchrist spoke to entrepreneurs in India, Hong Kong and the U.S. to learn more about the multibillion-dollar business opportunity.
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Continue reading “How the pandemic fast-tracked this multibillion-dollar industry | Make It International” »

3. Evolution shifts to off-world human colonies.

4. Transhumanism will drive evolution.

Is natural selection still a major force in human evolution? As far back as high school biology, we’ve been taught to think the answer must be yes. But is it really true?

Continue reading “Have humans reached the end of evolution? Not under these 4 scenarios” »

“The state government should consider managing the invasive population of spotted-thighed frogs at Streaky Bay. This should include education programs to inform people about what to do if they find a frog, as well as the feasibility of exterminating the population in South Australia.

“Importantly, if you do see one of these critters in your travels – leave it be. We don’t want it hitchhiking any further.”

Reference: ” Indiscriminate feeding by an alien population of the spotted-thighed frog (Litoria cyclorhyncha) in southern Australia and potential impacts on native biodiversity” by Christine M. Taylor, Gunnar Keppel, Shaun O’Sullivan, Stefan Peters, Gregory D. Kerr and Craig R. Williams, 9 April 2020, Australian Journal of Zoology. DOI: 10.1071/ZO19042

The president also ordered a boost in the education of specialists in genetics and genome sequencing and the domestic production of necessary laboratory equipment, as well as tax cuts for biomedical research. Russia will also open world-class genome research centers which will, among their immediate goals, work on the development of treatments and vaccines for Covid-19.

The future database will be one of the tools that Russia hopes to use to assume a leading position in the biomedical industry. The government sees it as crucial for keeping the country competitive on the world stage going forward.

The Kurchatov Institute, which is best known for nuclear research, has been tasked with laying the foundation for the database, choosing the storage format and making tools for search and analysis. The institute has experience in the secure handling of large amounts of sensitive data and operates a number of data centers across Russia which are used for scientific collaboration projects.