Lifeboat Foundation

The Adaptive Immunity and Immunoregulation Section (AIIS) in the Laboratory of Allergic Diseases at #NIAID is seeking an exceptional candidate for a postdoctoral fellowship position.

The National Institute of Allergy and Infectious Diseases (NIAID), one of the largest institutes in the National Institutes of Health (NIH), and part of the Department of Health and Human Services (HHS), conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases.

A postdoctoral fellowship position is available immediately in the Adaptive Immunity and Immunoregulation Section (AIIS) within the Laboratory of Allergic Diseases, NIAID. AIIS seeks highly motivated and collaborative candidates with a strong publication record who are capable of independent reasoning and excited about learning new technologies.

AIIS aims to define the cellular and molecular mechanisms controlling the balance between protective and pathogenic adaptive immune responses to allergens and pathogens. With a particular focus on memory T and B cells and T follicular helper (Tfh) cells, the lab utilizes state-of-the-art cellular and molecular approaches, including in vivo models of infection and allergy, multi-color flow cytometry, adoptive transfer experiments, cell fate tracking experiments, bone marrow chimeras, parabiosis surgery, imaging, conditional knockout and transgenic models, RNA-Seq, and single-cell technologies to characterize memory B-and T-cell responses in different models of food and respiratory allergens and infections.

Summary: Researchers identified specific plant compounds that provide antioxidant and neuroprotective effects, contributing to brain health beyond basic nutrition. By analyzing plant-based foods like lemon balm, sage, and elderberry, scientists linked compounds such as phenolics and terpenes to benefits like reducing oxidative stress and scavenging harmful reactive species.

Quercetin-rich foods, such as Queen Garnet plum and clove, showed strong potential to prevent neuron-like cell damage. This study sheds light on how plant-based diets and supplements could support brain health and manage neuroinflammation-related conditions.

Science and Technology: This was previously thought to be impossible:

This was previously thought to be impossible:

Scientists were astonished to find that recirculating a cocktail of preserving agents through a severed pig’s head caused the animal’s brain to show signs of life.

Continue reading “Doctors Intrigued by Treatment That Makes Dead Brains Show Signs of Life” »

One of the first warnings came in a paper published in 2021. There was an unexpected rise in pancreatic cancer among young people in the United States from 2000 to 2018. The illness can be untreatable by the time it is discovered, a death sentence.

With publication of that report, by Dr. Srinivas Gaddam, a gastroenterologist at Cedars-Sinai Medical Center, researchers began searching for reasons. Could the increase be caused by obesity? Ultraprocessed foods? Was it toxins in the environment?

Alternatively, a new study published on Monday in The Annals of Internal Medicine suggests, the whole alarm could be misguided.

The hypertension drug rilmenidine has been shown to slow down aging in worms, an effect that in humans could hypothetically help us live longer and keep us healthier in our latter years.

Previous research has shown rilmenidine mimics the effects of caloric restriction on a cellular level. Reducing available energy while maintaining nutrition within the body has been shown to extend lifespans in several animal models.

Whether this translates to human biology, or is a potential risk to our health, is a topic of ongoing debate. Finding ways to achieve the same benefits without the costs of extreme calorie cutting could lead to new ways to improve health in old age.

As a simple illustration, let’s say someone wanted to create a tomato sauce recipe, optimizing vitamin C and using sustainable tomatoes within a certain cost range. Journey Foods then taps into its database to generate an optimal recipe, and will continually push recommendations of top suppliers.

“Essentially, when people go to ChatGPT or something, and they’re asking them, ‘write this paper for me, or give me a social media post, speak to this audience,’ or whatever, right? It’s the same thing with our generative recipe recommendations,” Lynn said.

Except Lynn doesn’t use ChatGPT. Systems such as ChaptGPT gather data from the open internet, but Journey Foods gets its data from research institutions, academic journals, suppliers and manufacturers. Lynn said her business uses a lot of private, hard data that’s unstructured, with her company then giving it structure and doing so globally.

Bacteria modify their ribosomes when exposed to widely used antibiotics, according to research published in Nature Communications. The subtle changes might be enough to alter the binding site of drug targets and constitute a possible new mechanism of antibiotic resistance.

Escherichia coli is a common bacterium which is often harmless but can cause serious infections. The researchers exposed E. coli to streptomycin and kasugamycin, two drugs which treat bacterial infections. Streptomycin has been a staple in treating tuberculosis and other infections since the 1940s, while kasugamycin is less known but crucial in agricultural settings to prevent bacterial diseases in crops.

Both antibiotics tamper with bacteria’s ability to make new proteins by specifically targeting their ribosomes. These molecular structures create proteins and are themselves made of proteins and ribosomal RNA. Ribosomal RNA is often modified with chemical tags that can alter the shape and function of the ribosome. Cells use these tags to fine tune protein production.

Pesticides can be made more effective and environmentally friendly by improving how they stick to plant surfaces, thanks to new research led by Dr. Mustafa Akbulut, professor of chemical engineering at Texas A&M University.

Akbulut and his research group have developed an innovative pesticide delivery system called nanopesticides. These tiny technologies, developed through a collaboration between Texas A&M University’s engineering and agricultural colleges, Dr. Luis Cisneros-Zevallo, professor of Horticultural Science and Dr. Younjin Min, professor of Chemical Environ Engineering at University of California, Riverside, could change how we use pesticides.

“The U.S. is a world leader in agricultural production, feeding not just our nation but much of the world. Yet we are using pesticides in a way that is simply not sustainable—with a substantial fraction not reaching its intended target,” said Akbulut. “Our research shows that by optimizing the surface chemistry of pesticide carriers, we can make these essential crop protection tools more efficient.”

Recent research reveals that the immune system interacts with the body’s internal clock, influencing both fat storage and temperature regulation.

The discovery hints at why shift workers and others with irregular work, eating, or sleep patterns driven by the demands of modern life fall out of metabolic sync, and may hold potential for developing therapies to address obesity and prevent wasting.

The key finding—that an immune molecule within adipose (fat) tissue, known as interleukin-17A (IL-17A), plays a regulatory role in fat storage—holds significant therapeutic potential for addressing obesity, preventing wasting, and mitigating other metabolic disorders. By targeting this molecule, drug developers may gain a valuable new pathway for creating treatments aimed at these conditions.