Lifeboat Foundation

Age-related hearing loss impacts one in three adults between the ages of 64 and 75 in the US, and around half of these numbers are down to genes.

The extra kicker, though, is that because hearing involves a complex genetic toolkit, it also makes this kind of hearing loss incredibly difficult to treat.

A team of researchers has for the first time targeted age-related genetic hearing loss in a much older cohort of mice, which had a mutation of the human transmembrane serine protease 3 (TMPRSS3) gene that results in autosomal recessive deafness 8/10 (DFNB8/DFNB10).

A new genetics study of ant “social parasites” shows how complex sets of features can emerge rapidly and potentially split species.

How we’re linking together genetic material from thousands of people — modern and ancient — to trace our ancestors and the history of our evolution.

Summary: A novel study uncovers a peculiar pattern of decision-making in mice, influenced by a specific gene named Arc.

While searching for food, mice repeatedly visited an empty location instead of staying at a site abundant in food. However, mice lacking the Arc gene demonstrated a more practical approach, sticking with the food-rich site, thereby consuming more calories overall.

This unique research potentially opens the door for a new field, ‘decision genetics’, investigating the genetic influence on decision-making, possibly even in humans.

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Continue reading “Blood Test #3 in 2023: Supplements, Diet” »

Scientists have enhanced the efficiency of CRISPR/Cas9 gene editing by threefold using interstrand crosslinks, without resorting to viral material for delivery. This approach boosts the cell’s natural repair mechanisms, allowing for more accurate and efficient gene editing, potentially improving disease research and preclinical work.

Gene editing is a powerful method for both research and therapy. Since the advent of the Nobel Prize-winning CRISPR/Cas9 technology, a quick and accurate tool for genome editing discovered in 2012, scientists have been working to explore its capabilities and boost its performance.

Researchers in the University of California, Santa Barbara biologist Chris Richardson’s lab have added to that growing toolbox, with a method that increases the efficiency of CRISPR/Cas9 editing without the use of viral material to deliver the genetic template used to edit the target genetic sequence. According to their new paper published in the journal Nature Biotechnology, their method stimulates homology-directed repair (a step in the gene editing process) by approximately threefold “without increasing mutation frequencies or altering end-joining repair outcomes.”

I quoted and responded to this remark:

“…we probably will not solve death and this actually shouldn’t be our goal.” Well nice as she seems thank goods Dr Levine does not run the scientific community involved in rejuvenation.

Continue reading “The science of super longevity | Dr. Morgan Levine” »

While hearing aids and cochlear implants offer limited relief, no available treatment can reverse or prevent this group of genetic conditions, prompting scientists to evaluate gene therapies for alternative solutions.

One of the most promising tools used in these therapies—adeno associated virus (AAV) vectors—has galvanized the hearing-loss community in recent years.

So it is confirmed that the new variant of covid 19 virus is here but the actual spike now is in China. But will most likely spread globally much how previous viruses have done. Be sure to be prepared for another pandemic. Anyway what may be the possible cure would be new bioengineering techniques with crispr to eventually be immune to the virus like I have posted in some genetically engineered cells recently were made. But rest assured this could lead to a global pandemic because the current variant is taxing our current vaccination measures.

The country once had some of the harshest Covid restrictions on the planet, but the response from the government and the public is relatively muted this time.