Lifeboat Foundation

We know a lot about cancer, and yet, there is plenty we do not yet know. We do know that some cancers are genetic in nature and a series of changes in key genes can lead to identifiable malignancies down the line. We would certainly want to know what causes cancer in the first place.

Scientists have been trying to replicate the path a cell takes from being normal to becoming pre-cancerous (one of the earliest stages of cancer in which cells become abnormally shaped and sized) for quite some time now. It is a feat that requires human-derived cells to model how cancer comes to be.

Recently, researchers at The Stanford School of Medicine have been able to emulate some of the earliest stages of gastric cancer by starting with gastric organoids (a rudimentary version of the real stomach made from stem-cell-derived gastric cells) that have a single mutation. The study which was published in Nature outlines how the earliest changes in cells could be seen even before the precancerous stage.

New research provides evidence that an individual’s health behaviors and outcomes are influenced by the genetic makeup of their romantic partner. The findings, published in Behavior Genetics, indicate that your partner’s genetic tendencies can lead to changes in your own weight, smoking habits, or alcohol consumption over time.

The researchers conducted this study to investigate how a person’s partner can affect their health. They aimed to explore the concept of social genetic effects, which refers to the impact of genetic factors in one person’s environment, such as their partner’s genotype, on their own phenotype (observable characteristics or traits).

“I was mainly interested in exploring the combination of social science and genetics,” explained study author Kasper Otten of Utrecht University. “It is evident that behavior is partly genetically influenced, but much of the social sciences does not deal with this biological fact.

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Using artificial intelligence (AI) to combine data from full-body x-ray images and associated genomic data from more than 30,000 UK Biobank participants, a study by researchers at The University of Texas at Austin and New York Genome Center has helped to illuminate the genetic basis of human skeletal proportions, from shoulder width to leg length.

The findings also provide new insights into the evolution of the human skeletal form and its role in musculoskeletal disease, providing a window into our evolutionary past, and potentially allowing doctors to one day better predict patients’ risks of developing conditions such as back pain or arthritis in later life. The study also demonstrates the utility of using population-scale imaging data from biobanks to understand both disease-related and normal physical variation among humans.

“Our research is a powerful demonstration of the impact of AI in medicine, particularly when it comes to analyzing and quantifying imaging data, as well as integrating this information with health records and genetics rapidly and at large scale,” said Vagheesh Narasimhan, PhD, an assistant professor of integrative biology as well as statistics and data science, who led the multidisciplinary team of researchers, to provide the genetic map of skeletal proportions.

Summary: Researchers reveal how a fertilized egg cell, or zygote, initiates its own genetic program, a process known as zygote genome activation.

The research identifies the OBOX gene family as master-regulators, crucial for this activation. These genes instruct the enzyme RNA polymerase II to transcribe the right genes at the right time, beginning the embryo’s development.

The team suggests that the genes’ functions are redundant to ensure this critical transition occurs successfully.

Using cannabis may cause changes in the human body’s epigenome, a study of over 1,000 adults suggests. The epigenome functions like a set of switches, activating or deactivating genes to change how our bodies function.

“We observed associations between cumulative marijuana use and multiple epigenetic markers across time,” says Lifang Hou, a preventative medical doctor and epidemiologist from Northwestern University Feinberg School of Medicine.

Cannabis is a commonly used substance in the United States, with 49 percent of people trying it at least once, Hou and a team of US researchers report in their published paper. Some US states and other countries have made it legal, but we still don’t fully understand its effects on our health.

A newly described type of chemistry in fungi is both surprisingly common and likely to involve highly reactive enzymes, two traits that make the genes involved useful signposts pointing to a potential treasure trove of biological compounds with medical and chemical applications.

It was also nearly invisible to scientists until now.

In the last 15 years, the hunt for molecules from living organisms—many with promise as drugs, antimicrobial agents, chemical catalysts and even food additives—has relied on computer algorithms trained to search the DNA of bacteria, fungi and plants for genes that produce enzymes known to drive biological processes that result in interesting compounds.

Triple-negative breast cancer is a combative cancer type with a highly inflated histological grade that leads to poor theragnostic value. Gene, protein, and receptor-specific targets have shown effective clinical outcomes in patients with TNBC. Cells are frequently exposed to DNA-damaging agents. DNA damage is repaired by multiple pathways; accumulations of mutations occur due to damage to one or more pathways and lead to alterations in normal cellular mechanisms, which lead to development of tumors. Advances in target-specific cancer therapies have shown significant momentum; most treatment options cause off-target toxicity and side effects on healthy tissues.

A natural sugar called mannose is a type of hexose that is abundant in many different types of fruits. Recent studies have demonstrated that mannose has been found to be effective in promoting immune tolerance, suppressing inflammatory diseases, and efficient in suppressing tumors by suppressing glycolysis. However, it is not fully understood how mannose exerts its anticancer activity. Now, a study by Sanford Burnham Prebys and the Osaka International Cancer Institute has shed new light on the anticancer properties of mannose and suggests that mannose could be a helpful secondary treatment for cancer.

The findings are published in eLife in an article titled, “Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells.”

“Mannose has anticancer activity that inhibits cell proliferation and enhances the efficacy of chemotherapy,” wrote the researchers. “How mannose exerts its anticancer activity, however, remains poorly understood. Here, using genetically engineered human cancer cells that permit the precise control of mannose metabolic flux, we demonstrate that the large influx of mannose exceeding its metabolic capacity induced metabolic remodeling, leading to the generation of slow-cycling cells with limited deoxyribonucleoside triphosphates (dNTPs).”