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DeepMind has released a catalog of 71 million possible variants that can cause diseases.

Genetic mutations are changes to our DNA sequence. This happens when cells make copies of themselves during cell division. Mutation is the ultimate source of human genetic variation and has evolutionary and disease genetics implications. A mutation affecting our genes might give birth to a genetic disorder. But just because you have a mutation doesn’t mean it will be a genetic disorder.

That is why researchers at DeepMind, the artificial intelligence arm of Google, have announced that they have trained a machine learning model called AlphaMissense to classify which DNA variations in our genomes are likely to cause disease.

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There is powerful science behind how our beliefs inform our genetic expression. It’s not our genes alone that dictate our health outcomes, rather it’s the biology of belief that determines our destiny.

Today on The Doctor’s Farmacy, I’m excited to talk to Dr. Bruce Lipton about how exactly our thoughts determine our genetic expression, and how we can influence our health using our minds.

Dr. Bruce Lipton is a stem cell biologist and author of the bestselling books, The Biology of Belief, Spontaneous Evolution, and The Honeymoon Effect. Dr. Lipton is the recipient of the prestigious Japanese Goi Peace Award and has been listed in the top 100 of “the world’s most spiritually influential people” by Briton’s Watkins Journal for the last 13 years.

This episode is brought to you by Rupa Health, BiOptimizers, LMNT, and Apollo.

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Studying genes in families with a propensity for certain diseases has led to many critical advances in medicine, including the discovery of statins in family members who suffered heart attacks at an early age.

Now, a team of researchers at Case Western Reserve University has identified an in a gene linked to a highly lethal cancer called (EAC).

“With this discovery, we will be able to identify early those at a high risk of developing EAC in their lifetime, and accordingly tailor screening, lifestyle and treatment strategies to prevent cancer development,” said Kishore Guda, an associate professor at the Case Western Reserve School of Medicine and member of the Case Comprehensive Cancer Center.

New research indicates that butterflies and moths share “blocks” of DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

New research provides insight about the bedrock scientific principle that mitochondrial DNA -; the distinct genetic code embedded in the organelle that serves as the powerplant of every cell in the body -; is exclusively passed down by the mother.

The study, a collaboration among Oregon Health & Science University and other institutions, published today in the journal Nature Genetics.

Scientists have long recognized the fact that mitochondrial DNA, or mtDNA, comes exclusively from egg cells in humans, meaning only the mother contributes the genetic code carried by thousands of mitochondria necessary for energy production in every cell in the body.

CRISPR-based genome editing has the potential to treat many human genetic diseases, but achieving stable, efficient and safe in vivo delivery remains a challenge. This Review assesses current delivery systems for genome editors—focusing on adeno-associated viruses and lipid nanoparticles—and highlights data from recent clinical trials. Emerging delivery systems and ongoing challenges in the field are discussed.

Summary: Researchers pioneered a groundbreaking method called “CHOOSE” to investigate genes tied to autism spectrum disorder (ASD) within human tissue. This technique allows for simultaneous examination of key transcriptional regulator genes linked to autism in a single organoid.

Utilizing CHOOSE, the team pinpointed mutations in 36 genes known to heighten autism risk, shedding light on how they influence brain development. The revelations from these organoids mirrored clinical observations, underscoring the potential of this method in advancing our understanding of neurodevelopmental disorders.