Lifeboat Foundation

Check out Brilliant here: https://brilliant.org/Eons.

In the search for the genes that make us human, some of the most important answers were hiding not in the genes themselves, but in what was once considered genomic junk.

Continue reading “The Hidden Genes That Make Us Human” »

Researchers at Texas A&M University have developed the first molecular therapeutic for Angelman syndrome to advance into clinical development.

In a new article, published today in Science Translational Medicine, Dr. Scott Dindot, an associate professor and EDGES Fellow in the Texas A&M School of Veterinary Medicine and Biomedical Sciences’ (VMBS) Department of Veterinary Pathobiology, and his team share the process through which they developed this novel therapeutic candidate, also known as 4.4.PS.L, or GTX-102. Dindot is also the executive director of molecular genetics at Ultragenyx, which is leading the development of GTX-102.

Angelman syndrome (AS) is a devastating, rare neurogenetic disorder that affects approximately 1 in 15,000 live births per year; the disorder is triggered by a loss of function of the maternal UBE3A gene in the brain, causing developmental delay, absent speech, movement or balance disorder, and seizures.

Changes in the brain caused by Alzheimer’s disease are associated with shortening of the telomeres—the protective caps on the ends of chromosomes that shorten as cells age—according to a new study led by Anya Topiwala of Oxford Population Health, part of the University of Oxford, UK, published March 22 in the open-access journal PLOS ONE.

Telomeres on chromosomes protect DNA from degrading, but every time a cell divides, the telomeres lose some of their length. Short telomeres are a sign of stress and cellular aging, and are also associated with a higher risk of neurological and psychiatric disorders. Currently, little is known about the links between telomere length and changes that occur in the brains of people with neurological conditions. Understanding those relationships could offer insights into the biological mechanisms that cause neurodegenerative disorders.

In the new study, researchers compared telomere length in white blood cells to results from brain MRIs and electronic health records from more than 31,000 participants in the UK Biobank, a large-scale biomedical database and research resource containing anonymized genetic, lifestyle and health information from half a million UK participants.

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Discount Links:
NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout.

Continue reading “NAD Test #3: Impact of 1000 mg NMN/d?” »

Recently biologists discovered how to generate new neurons in the adult brain. This is an incredible breakthrough that has enormous potential to revolutionize neurodegenerative disease research. By generating genetically-mutated mice with a unique gene that activates dormant neural stem cells, scientists were able to generate new neurons in the brain. For years, scientists have been searching for ways to promote the growth of new neurons in the brain, especially in individuals with neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This new discovery could lead to new treatments and therapies that could help to restore brain function and improve the quality of life for millions of people around the world.

Leslie Samuel, founder of Interactive Biology, gives some context for the importance of genetic trading between organisms for scientific research, and notes how the loss of nerve cells in the brain is one of the hallmarks of neurodegenerative diseases. The ability to generate new neurons in the adult brain could be a game-changer in the field of neurology.

Leslie’s Thoughts

So, 22% increase. Roughly like a 120 person, which means if this literally translates to people it means a maximizing of our current lifespan. The rest is just a rundown of Aubrey’s experiment.

Dr Katcher’s lifespan experiment has come to an end as the last remaining rat, Sima, has died. She was 1,464 days old which is a record for Sprague-Dawley rats. We also talk about the exciting Robust Mouse Rejuvenation project at the LEV Foundation.

Continue reading “Dr Katcher’s E5 Lifespan Experiment Final Result | 22% Lifespan Extension” »

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Discount Links:
NAD+ Quantification: https://www.jinfiniti.com/intracellular-nad-test/
Use Code: ConquerAging At Checkout.

Continue reading “Blood Test #2 in 2023: Impact of NMN?” »

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Martian soil is generally poor for growing plants, but researchers have used CRISPR to create gene-edited rice that might be able to germinate and grow despite the hostile habitat.

By Leah Crane

Continue reading “Gene-edited rice may be able to grow on Mars” »

The research team used a new CRISPR-based genome editing system named PESpRY.

Scientists in China have effectively treated retinitis pigmentosa.

The research team utilized a novel form of CRISPR-based genome editing that is exceptionally adaptable and could potentially remedy numerous genetic mutations responsible for causing different diseases.