In 1971, scientists turned to genetics to control disease-spreading mosquitoes without DDT. Today, there are a variety of pesticide-free methods.
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Roche and its Genentech subsidiary have committed up to $12 billion to Recursion in return for using its Recursion Operating System (OS) to advance therapies in 40 programs that include “key areas” of neuroscience and an undisclosed oncology indication.
Recursion OS applies machine learning and high-content screening methods in what the companies said would be a “transformational” model for tech-enabled target and drug discovery.
The integrated, multi-faceted OS is designed to generate, analyze and glean insights from large-scale proprietary biological and chemical datasets—in this case, extensive single-cell perturbation screening data from Roche and Genentech—by integrating wet-lab and dry-lab biology at scale to phenomically capture chemical and genetic alterations in neuroscience-related cell types and select cancer cell lines.
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Jamie Metzl is an author specializing in topics of genetic engineering, biotechnology, and geopolitics.
Continue reading “Sam Harris and Brett Weinstein Twitter feud | Jamie Metzl and Lex Fridman” »
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Yesterday’s longevity AMA: michael lustgarten, phd.
Questionsabout yesterday’s video, and more…AMA!
The earliest genetic traces of Native American ancestry among Polynesians.
The peopling of Polynesia was a stunning achievement: Beginning around 800 C.E., audacious Polynesian navigators in double-hulled sailing canoes used the stars and their knowledge of the waves to discover specks of land separated by thousands of kilometers of open ocean. Within just a few centuries, they had populated most of the Pacific Ocean’s far-flung islands. Now, researchers have used modern DNA samples to trace the exploration in detail, working out what order the islands were settled in and dating each new landfall to within a few decades.
“The whole question of the settlement of Polynesia has been going on for 200 years,” says University of Hawaii, Manoa, archaeologist Patrick Kirch, who was not involved in the research. “This is a really great paper, and I’m happy to see it.”
And some of the genetic programming for this regenerative superpower may have been passed down to humans.
Chinese scientists developed a targeted delivery system that can conduct precise gene-editing for inflammatory bowel disease. /CFP
Chinese scientists have developed a targeted delivery system that can bring gene-editing tools to colon cells, offering a precise cure for inflammatory bowel disease.
The study, published on Thursday in the journal Science Advances, reported a CRISPR-Cas9 prodrug nanosystem that can transport a gene-editing protein exclusively to inflammatory lesions in mice colons and then “switch on” the protein.
Many intractable diseases are the result of a genetic mutation. Genome editing technology promises to correct the mutation and thus new treatments for patients. However, getting the technology to the cells that need the correction remains a major challenge. A new study led by CiRA Junior Associate Professor Akitsu Hotta and in collaboration with Takeda Pharmaceutical Company Limited as part of the T-CiRA Joint Research Program reports how lipid nanoparticles provide an effective means for the delivery to treat Duchenne muscular dystrophy (DMD) in mice.
Last year’s Nobel Prize for Chemistry to the discoverers of CRISPR-Cas9 cemented the impact of genome editing technology. While CRISPR-Cas9 can be applied to agriculture and livestock for more nutritious food and robust crops, most media attention is on its medical potential. DMD is just one of the many diseases that researchers foresee a treatment using CRISPR-Cas9.
“Oligonucleotide drugs are now available for DMD, but their effects are transient, so the patient has to undergo weekly treatments. On the other hand, CRISPR-Cas9 effects are long lasting,” said Hotta.
