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Changing the number of chromosomes an animal has can take millions of generations to happen in nature through the course of evolution – and now, scientists have been able to make these same changes in lab mice in a relative blink of an eye.

The new technique using stem cells and gene editing is a major accomplishment, and one that the team is hoping will reveal more about how the rearrangement of chromosomes can influence the way that animals evolve over time.

It’s in chromosomes – those strings of protein and DNA inside cells – that we find our genes, inherited from our parents and blended together to make us who we are.

Analysis of the genome and proteome shows that eukaryotic evolution gave rise to the regulatory function of chromatin.

Two meters of DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

This finding “proved” the significance of chromosomal rearrangement, a crucial evolutionary indicator of the emergence of a new species.

Researchers from the Chinese Academy of Sciences (CAS) claim to have found a novel technique for programmable chromosome fusion successfully producing mice with genetic changes “that occur on a million-year evolutionary scale” in the laboratory.

The findings could shed light on how chromosome rearrangements—the tidy packages of organized genes provided in equal numbers by each parent, which align and trade or blend traits to produce offspring—influence evolution, reported Phys.org on Thursday.


Evolutionary chromosomal changes may take a million years in nature, but researchers are now reporting a novel technique enabling programmable chromosome fusion that has successfully produced mice with genetic changes that occur on a million-year evolutionary scale in the laboratory. The result may provide critical insights into how rearrangements of chromosomes—the tidy packages of organized genes, provided in equal number from each parent, which align and trade or blend traits to produce offspring—influence evolution.

In results published today in Science, the researchers reveal that chromosome-level engineering can be achieved in mammals, and they successfully derived a laboratory house mouse with novel and sustainable karyotype, providing critical insight into how may influence evolution.

“The laboratory house mouse has maintained a standard 40-chromosome karyotype—or the full picture of an organism’s chromosomes—after more than 100 years of artificial breeding,” said co-first author Li Zhikun, researcher in the Chinese Academy of Sciences (CAS) Institute of Zoology and the State Key Laboratory of Stem Cell and Reproductive Biology. “Over longer time scales, however, karyotype changes caused by chromosome rearrangements are common. Rodents have 3.2 to 3.5 rearrangements per million years, whereas primates have 1.6.”

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Program & apply to join: https://foresight.org/existential-hope/

In the Existential Hope-podcast (https://www.existentialhope.com), we invite scientists to speak about long-termism. Each month, we drop a podcast episode where we interview a visionary scientist to discuss the science and technology that can accelerate humanity towards desirable outcomes.

Xhope Special with Foresight Fellow Morgan Levine.

Morgan Levine is a ladder-rank Assistant Professor in the Department of Pathology at the Yale School of Medicine and a member of both the Yale Combined Program in Computational Biology and Bioinformatics, and the Yale Center for Research on Aging. Her work relies on an interdisciplinary approach, integrating theories and methods from statistical genetics, computational biology, and mathematical demography to develop biomarkers of aging for humans and animal models using high-dimensional omics data. As PI or co-Investigator on multiple NIH-, Foundation-, and University-funded projects, she has extensive experience using systems-level and machine learning approaches to track epigenetic, transcriptomic, and proteomic changes with aging and incorporate.
this information to develop measures of risk stratification for major chronic diseases, such as cancer and Alzheimer’s disease. Her work also involves development of systems-level outcome measures of aging, aimed at facilitating evaluation for geroprotective interventions.

Existential Hope.
A group of aligned minds who cooperate to build beautiful futures from a high-stakes time in human civilization by catalyzing knowledge around potential paths to get there and how to plug in.

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Researchers at Washington University School of Medicine in St. Louis have found a new druggable pathway that potentially could be used to help prevent Alzheimer’s dementia.

Amyloid beta accumulation in the brain is the first step in the development of Alzheimer’s dementia. Scientists have poured countless hours and millions of dollars into finding ways to clear amyloid away before cognitive symptoms arise, with largely disappointing results.

In this study, published Aug. 24 in the journal Brain, researchers found a way to increase clearance of waste products from the brains of mice by ramping up a genetic quirk known as readthrough. This same strategy also may be effective for other characterized by the buildup of toxic proteins, such as Parkinson’s disease, the researchers said.

Basically this means halting and controlling cellular death which would reverse the death process :3.


During pyroptosis, gasdermin D (GSDMD) forms plasma membrane pores that initiate cell lysis. Here, the authors develop optogenetically activatable human GSDMD to assess GSDMD pore behavior and show that they are dynamic and can close, which can be a pyroptosis regulatory mechanism.

“These results will have future implications in forensic medicine and genetic diagnosis.”

In 1999, François Brunelle, a Canadian artist, and photographer, began documenting look-alikes in a picture series “I’m not a look-alike!”

The project, undoubtedly, was a massive hit on social media and other parts of the internet, but it also drew the attention of scientists who study genetic relationships.

TABLE OF CONTENTS —————
0:00–15:11 : Introduction.
15:11–36:12 CHAPTER 1: POSTHUMANISM
a. Neurotechnology b. Neurophilosophy c. Teilhard de Chardin and the Noosphere.

TWITTER https://twitter.com/Transhumanian.
PATREON https://www.patreon.com/transhumania.
BITCOIN 14ZMLNppEdZCN4bu8FB1BwDaxbWteQKs8i.
BITCOIN CASH 1LhXJjN4FrfJh8LywR3dLG2uGXSaZjey9f.
ETHEREUM 0x1f89b261562C8D4C14aA01590EB42b2378572164
LITECOIN LdB94n8sTUXBto5ZKt82YhEsEmxomFGz3j.
CHAINLINK 0xDF560E12fF416eC2D4BAECC66E323C56af2f6666.

POSTHUMAN TECHNOLOGY

36:12–54:39 CHAPTER 2 : TELEPATHY/ MIND-READING
a. MRI
b. fMRI
c. EEG
d. Cognitive Liberty e. Dream-recording, Dream-economies f. Social Credit Systems g. Libertism VS Determinism.

1:02:07–1:25:48 : CHAPTER 3 : MEMORY/ MIND-AUGMENTING
a. Memory Erasure and Neuroplasticity b. Longterm Potentiation (LTP/LTD)
c. Propanolol d. Optogenetics e. Neuromodulation f. Memory-hacking g. Postmodern Dystopias h. Total Recall, the Matrix, and Eternal Sunshine of the Spotless Mind i. Custom reality and identity.

1:25:48–1:45:14 CHAPTER 4 : BCI/ MIND-UPGRADING