Lifeboat Foundation

Follow the links in the story for sources, the text is in red. A new strain of COVID-19 is causing a wave of new lockdowns in London and travel restrictions for those coming from the U.K. because some are worried that this may be an even more contagious version of the coronavirus. Experts say it’s definitely something to watch out for, but it’s not clear whether or not this variant is actually more transmissible—and there’s no reason to think the current COVID-19 vaccines won’t be effective against it. So what exactly is different about this new strain of COVID-19? Well, this variant (also called B. 1. 1. 7.) has a few mutations, 17 to be exact. Not all of them are concerning, but a few are. The mutations that have experts a little on edge have to do with genes that encode the virus’s spike protein, which is located on the surface of the virus and is the piece of the virus that helps it actually bind to human cells. (That’s the first step in becoming infected.) One of these mutations (called N501Y) may make it easier for the spike protein to bind to the receptors on our cells, Science explains. Another mutation (called 69-70del) affects the number of amino acids (the building blocks that make up a protein) in the spike protein, and variants with this mutation have been previously identified in some immunocompromised people whose bodies were unable to muster the necessary immune response to protect them from the virus.

It’s causing new lockdowns and travel restrictions.

A team of Johns Hopkins University researchers has developed a new software that could revolutionize how DNA is sequenced, making it far faster and less expensive to map anything from yeast genomes to cancer genes.

The software, detailed in a paper published in Nature Biotechnology, can be used with portable sequencing devices to accelerate the ability to conduct genetic tests and deliver diagnoses outside of labs. The new technology targets, collects and sequences specific genes without sample preparation and without having to map surrounding genetic material like standard methods require.

“I think this will forever change how DNA sequencing is done,” said Michael C. Schatz, a Bloomberg Distinguished Associate Professor of Computer Science and Biology and senior author of the paper.

Summary: Artificial intelligence technology redesigned a bacterial protein that helps researchers track serotonin in the brain in real-time.

Source: NIH

Serotonin is a neurochemical that plays a critical role in the way the brain controls our thoughts and feelings. For example, many antidepressants are designed to alter serotonin signals sent between neurons.

Continue reading “AI-Designed Serotonin Sensor May Help Scientists Study Sleep and Mental Health” »

Video on the gene edited mosquitos to be released in Florida.

The U.S. EPA gave the green light to release millions of genetically modified mosquitoes in the Florida Keys in 2021 — here’s what we know.

Using CRISPR to alter the genetics of astrocytes in mice, researchers hope they’ve discovered how to regenerate neurons in patients with Parkinsons disease.

Using CRISPR/Cas9 gene editing tools, researchers introduced a common Parkinson’s disease mutation into stems cells of the marmoset monkey for a first time, paving the way toward a primate model of this disease.

Nice lecture with both technical info and analogy.

Latest study from David Sinclair’s lab have used cellular reprogramming to restore vision in aged mice & more! Suggests reversing aging *may* be possible.

Continue reading “Reversing aging through cellular reprogramming!?” »

Dr. Steve Horvath, a professor of genetics and biostatistics at UCLA, has found a way to measure biological aging – a type of “clock” – based on the methylation pattern of an organism’s genome. Methylations are biochemical processes that modify the activity of a DNA segment without changing its sequence – a type of epigenetic change. This video primer explains the basics of epigenetic clocks, the topic of our interview with Dr. Steve Horvath, coming soon!

Get the show notes here:
https://www.foundmyfitness.com/episodes/epigenetic-clock/

Continue reading “Epigenetic Aging: How old is your DNA?” »

Rusted iron pipes can react with residual disinfectants in drinking water distribution systems to produce carcinogenic hexavalent chromium in drinking water, reports a study by engineers at UC Riverside.

Chromium is a metal that occurs naturally in the soil and groundwater. Trace amounts of trivalent chromium eventually appear in the drinking water and food supply and are thought to have neutral effects on health. Chromium is often added to iron to make it more resistant to corrosion.

Certain chemical reactions can change chromium atoms into a hexavalent form that creates cancer-causing genetic mutations in cells. This carcinogenic form of chromium was at the heart of a lawsuit in California’s Central Valley by Erin Brockovich, which became the subject of an Oscar-winning movie.