Lifeboat Foundation

The most common organism in the oceans, and possibly on the entire planet, is a family of single-celled marine bacteria called SAR11. These drifting organisms look like tiny jelly beans and have evolved to outcompete other bacteria for scarce resources in the oceans.

We now know that this group of organisms thrives despite—or perhaps because of—the ability to host viruses in their DNA. A study published in May in Nature Microbiology could lead to new understanding of viral survival strategies.

University of Washington oceanographers discovered that the bacteria that dominate seawater, known as Pelagibacter or SAR11, hosts a unique virus. The virus is of a type that spends most of its time dormant in the host’s DNA but occasionally erupts to infect other cells, potentially carrying some of its host’s genetic material along with it.

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For the first time, scientists have found a genetic mutation that appears to offer a measure of protection against some of the biological effects of ageing.

Continue reading “First Ever Anti-Ageing Gene Discovered in a Secluded Amish Family” »

An international team of scientists has identified 29 independent genetic risk variants — 19 of them novel — linked to problematic alcohol use and revealed genetic relationships with numerous other traits.

Whereas textbooks depict metabolism in perfect homeostasis, disturbances occur in real life. One particularly relevant disturbance, caused by excess food and alcohol consumption and exacerbated by genetics, is reductive stress. New work by Goodman et al. identifies a biomarker of reductive stress and uses a gene therapy solution in mice. This work suggests how exercise and an accessible nutritional technology can synergistically increase catabolism and relieve reductive stress.

Sirtuins, telomeres, A.I. experiment with vitamin A and personalized medicine, a bit of everything here.

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Continue reading “BRIAN KENNEDY — Reversing Human Aging (#0004)” »

Not all viruses set out to cause widespread death and sickness — some have the potential to fight cancer, according to new research.

Researchers from Hokkaido University in Japan have genetically engineered adenoviruses, which is a family of viruses that cause mild symptoms, to replicate inside cancer cells and kill them, according to a new paper in the journal Cancers.

To do this, Fumihiro Higashino, a molecular oncologist, and his team inserted adenylate-uridylate-rich elements (AREs) from two human genes — a stabilizing element found in a type of macromolecule present in all biological cells — into two strains of the virus to help specifically attack cancer cells.

Landmark study identifies the genes that it seems people can and cannot live without and highlights ongoing challenges in making data sets more representative of the world’s population.

CRISPR gene-editing trials have taken off—and may hold the key to medical breakthroughs.

[Illustration: Jamie Cullen]

A key epigenetic mark can block the binding of an important gene regulatory protein, and therefore prohibit the gene from being turned off, a new UNSW study in CRISPR-modified mice—published this month in Nature Communications —has shown.

The study has implications for understanding how epigenetics works at a molecular level—and down the track, the scientists hope the research will help them to investigate new treatments for blood disorders.

“Epigenetics looks at how non-permanent, acquired chemical marks on DNA determine whether or not particular genes are expressed,” study leader and UNSW Professor Merlin Crossley says.