Lifeboat Foundation

Project Recode may be the most ambitious science experiment of our time – genetically engineering humans to be virus-resistant.

Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) and the FIRC Institute of Molecular Oncology (IFOM) in Italy, has revealed that mature cells can be reprogrammed into re-deployable stem cells without direct genetic modification — by confining them to a defined geometric space for an extended period of time.

“Our breakthrough findings will usher in a new generation of stem cell technologies for tissue engineering and regenerative medicine that may overcome the negative effects of geonomic manipulation,” said Prof Shivashankar.

Researchers isolated several mutations leading to melanoma and reproduced them in the lab using CRISPR.

Two papers authored by researchers at the University of California, San Francisco described the genetic changes that turn harmless moles into malignant melanomas and the experiment they devised to recreate the step-by-step evolution of normal skin cells into cancer cells [1], [2].

Summary ([1])

Continue reading “Two Papers Trace The Steps Leading From Moles to Melanomas” »

Derrick Broze, Guest Waking Times

New scientific research is causing scientists to rethink what they believe about the static nature of genes. What do these discoveries mean for a species increasingly facing environmental and political calamity?

Ongoing discoveries regarding how environmental factors can affect life on the genetic level are causing many scientists and researchers to rethink the notion that the genetic makeup of an individual is static and unchanging. Most recently, a team of researchers with Tufts University has found evidence which suggests stress or mistreatment during childhood can lead to genetic changes which are passed down to the victim’s children and grandchildren. Larry Feig and his team have shown that inducing stress on mice can lead to genetic changes which are imprinted on the sperm. This same effect has been found in male humans as well.

Continue reading “What Does Epigenetics Mean for Humanity’s Awakening?” »

Canadian researchers have discovered a new and direct molecular mechanism to stop cancer cells from proliferating. In the prestigious journal Nature Cell Biology, scientists from Université de Montréal show that a disruption of a fine balance in the composition of ribosomes (huge molecules that translate the genetic code into proteins) results in a shutdown of cancer cell proliferation, triggering a process called senescence.

“Ribosomes are complex machines composed of both RNAs and proteins that make all the proteins necessary for cells to grow,” said UdeM biochemistry professor Gerardo Ferbeyre, the study’s senior author. Cancer cells grow and proliferate relentlessly and thus require a massive amount of ribosomes, he explained. Growing cells must coordinate the production of both ribosomal RNAs and ribosomal proteins in order to assemble them together in strict proportion to each other.

“We were surprised, however, to find that if the production of ribosomal RNA–protein proportions are driven out of balance in a cancer cell, proliferation can be shut down by in a very simple and direct manner,” said Ferbeyre.

Continue reading “Scientists discover a new mechanism that prevents the proliferation of cancer cells” »

https://wisechase.tv/the-bugs-that-reverse-damage/

https://www.youtube.com/watch?v=Nufc8vTsbBY

Life extension genetics.

Many factors contribute to exceptional longevity, with genetics playing a significant role. However, to date, genetic studies examining exceptional longevity have been inconclusive. This comprehensive review seeks to determine the genetic variants associated with exceptional longevity by undertaking meta-analyses.

Meta-analyses of genetic polymorphisms previously associated with exceptional longevity (85+) were undertaken. For each variant, meta-analyses were performed if there were data from at least three independent studies available, including two unpublished additional cohorts.

Continue reading “Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity” »

“I believe gene therapy will become a mainstay in treating, and maybe curing, many of our most devastating and intractable illnesses,” said FDA commissioner Dr Scott Gottlieb after Luxturna’s approval.

As innovative gene and cell therapies continue to make the transition from the laboratory to the clinic, they are bringing with them the promise of truly personalised medicine. The last few years have seen the regulatory approval of the first gene therapies that take a patient’s own immune cells and genetically engineer them to target cancer cells more effectively.

These chimeric antigen receptor T-cell (CAR-T) therapies now represent a rapidly growing field, with Novartis’s Kymriah, the first CAR-T therapy approved by the US Food and Drug Administration (FDA) in August 2017 for the treatment of a rare blood cancer, seen as the tip of the iceberg for this treatment class’ potential. Approval of Kite Pharma’s Yescarta, a CAR-T treatment for certain forms of non-Hodgkin lymphoma, followed just a few months later.

Continue reading “Can the gene and cell therapy revolution scale up?” »