Lifeboat Foundation

In August, the Food and Drug Administration (FDA) granted accelerated approval of Tecelra (afamitresgene autoleucel)— the first T-cell receptor therapy for solid tumors—for people with inoperable or metastatic synovial sarcoma. Tecelra is a gene therapy created from a patient’s own T cells. A sample of cells is removed and genetically modified to express a natural T-cell receptor that targets MAGE-A4, an antigen expressed on cancer cells. In the Phase II SPEARHEAD-1 trial, the overall response rate was 43%, and 39% of responders were still doing well a year later.

Avalo, a crop development company based in North Carolina, is using machine learning models to accelerate the creation of new and resilient crop varieties.

The traditional way to select for favorable traits in crops is to identify individual plants that exhibit the trait – such as drought resistance – and use those plants to pollinate others, before planting those seeds in fields to see how they perform. But that process requires growing a plant through its entire life cycle to see the result, which can take many years.

Avalo uses an algorithm to identify the genetic basis of complex traits like drought, or pest resistance in hundreds of crop varieties. Plants are cross-pollinated in the conventional way, but the algorithm can predict the performance of a seed without needing to grow it – speeding up the process by as much as 70%, according to Avalo chief technology officer Mariano Alvarez.

Northwestern Medicine investigators have discovered new molecular mechanisms underlying DNA repair dysregulation in prostate cancer cells, findings that may inform the development of new targeted therapies for patients that have become resistant to standard treatments, according to a recent study published in Science Advances.

Qi Cao, Ph.D., the Anthony J. Schaeffer, MD, Professor of Urology, was senior author of the study.

DNA damage is a natural occurrence in cells caused by various intercellular and external stressors. However, if left unrepaired, this damage can lead to genetic mutations that can lead to the development of different diseases, including cancer.

Astronauts and commercial space travelers are subject to damaging radiation and microgravity, along with other potential injuries. We need better ways to protect them.

Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell makes a copy of DNA, called mRNA. Then, another molecule called a ribosome reads the mRNA, translating it into protein. But this step has been a visual mystery; scientists previously did not know how the ribosome attaches to and reads mRNA.

Now, a team of international scientists, including University of Michigan researchers, has used advanced microscopy to image how ribosomes recruit to mRNA while it’s being transcribed by an enzyme called RNA polymerase (RNAP). Their results, which examine the process in bacteria, are published in the journal Science.

“Understanding how the ribosome captures or ‘recruits’ the mRNA is a prerequisite for everything that comes after, such as understanding how it can even begin to interpret the information encoded in the mRNA,” said Albert Weixlbaumer, a researcher from Institut de génétique et de biologie moléculaire et cellulaire in France who co-led the study.

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to systematically discover and understand such antibiotic relationships.

A groundbreaking study has used patient-derived stem cells to recreate a rare genetic form of autism in the lab.

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Continue reading “Viruses Contribute To Aging And Age-Related Diseases: Amy Proal, PhD” »

Scientists from the Longevity Research Institute (LRI), which was formed by the merger of SENS Research Foundation and Lifespan.io, have achieved expression of an essential mitochondrial gene in the nucleus and proper functioning of the protein. This could pave the way for curing diseases caused by mitochondrial mutations [1].

The fragile mitochondrial DNA

The prevailing scientific consensus is that mitochondria were once independent microorganisms that entered a symbiotic relationship with larger cells. This duo gave rise to eukaryotic cells: the building blocks of all multicellular life. Without that fateful “marriage,” complex life would not exist, as mitochondria provide cells with essential energy via oxidative phosphorylation.