Lifeboat Foundation

ACE, a groundbreaking DNA-powered signal amplification technology, significantly enhances the sensitivity of mass cytometry, providing new insights into various biological and pathological processes.

Since the 1950s, researchers have employed “flow cytometry,” a renowned technique devised by Wallace Coulter, to characterize various types of immune cells in research studies and human blood samples. This method has significantly enhanced our understanding of immune cell development and provided innovative approaches for evaluating human health and diagnosing various blood cancers. Eventually, flow cytometry was extended to analyze other cell types as well.

In traditional flow cytometry, cell surface and intracellular proteins are detected with antibody molecules that are linked to fluorescent probes. However, while providing single-cell sensitivity, this method is limited in detecting multiple proteins by the number of fluorophores that can be clearly distinguished within the entire spectrum of fluorescent light.

It seems that Silicon Valley giants, AAA game developers, and other companies desperately clinging to the AI trend and trying to integrate the technology into any product they own will soon have to rethink their marketing strategies, as a new study conducted by researchers from Washington State University indicates that using terms like “AI” or “artificial intelligence” in product descriptions can negatively impact sales.

To explore the impact of including “AI” in goods and service descriptions on consumers’ purchase intentions, the team conducted six experiments and surveyed over a thousand people, discovering that the use of these terms decreases purchase intention and lowers emotional trust, leading to what any company fears the most – diminishing sales numbers.

Furthermore, the researchers found that putting artificial intelligence in the spotlight can be even more detrimental when it comes to high-risk products – those consumers typically think twice about buying, such as expensive gadgets and medical services – compared to low-risk items, primarily because of the greater likelihood of incurring monetary losses or facing health risks.

A UCSF study reveals that higher inflammation levels in young adults are associated with poorer cognitive performance in midlife, underscoring the importance of lifestyle choices in reducing inflammation and preventing cognitive decline.

Higher levels of inflammation in young adults, associated with factors like obesity, physical inactivity, chronic illness, stress, and smoking, are linked to decreased cognitive function in midlife, according to a new study from UC San Francisco.

Researchers previously linked higher inflammation in older adults to dementia, but this is one of the first studies to connect inflammation in early adulthood with lower cognitive abilities in midlife.

Microwave technology has dramatically progressed, marked by the arrival of the 5G era, owing to the advantages of electromagnetic waves in long-distance, wireless, and high-speed transmissions. However, electromagnetic wave pollution problems such as electromagnetic wave interference and electromagnetic wave radiation are becoming increasingly serious.

Electromagnetic wave pollution not only affects the normal operation of electronic equipment, greatly threatens the information security of the scientific community, but also endangers human health and is a possible cause of cancer and sensitized diseases.

SiOC precursor ceramics have great application potential in electromagnetic protection because of their advantages such as lightweight, high-temperature resistance, and molecular designability. The main challenge of polymer-derived ceramic-based composites for electromagnetic wave absorption is the single loss mechanism, resulting in inferior electromagnetic wave attenuation ability.

A city in Southern California has become the first in the nation to replace its police patrol cars with electric vehicles, officials announced Monday, unveiling a fleet of 20 new Teslas.

South Pasadena on the edge of Los Angeles will replace its gas-guzzling police cruisers with the Teslas to help protect public health and fight climate change through reducing emissions. The Teslas will use new electric vehicle chargers installed at City Hall, officials said.

(CNN) — Regular aspirin use may keep the oncologist away, at least when it comes to colorectal cancer, according to a new study, and people with unhealthy lifestyles seemed to see the greatest benefit.

Colorectal cancer is the second most common cause of cancer death worldwide, predicted to cause more than 52,500 deaths in the US alone in 2023. About 153,020 people in the US were diagnosed with the condition in 2023, and it’s become much more prevalent among people under 55, with numbers more than doubling in this group from a decade ago, studies show.

The causes of colorectal cancer can be genetic, but certain lifestyle factors also seem to raise risk, including eating an unhealthy diet, not getting enough exercise, drinking alcohol, smoking and having a high body mass index.

Everyone knows that exercise helps both body and mind, but high-intensity interval training (HIIT) offers older adults an even greater boost for long-term brain health, compared to less intense workouts.

Future studies can now be designed to understand the discovery in greater depth and use it to develop treatments. “The essential next step is to investigate the efficacy of IL-22BP inhibitors in animal models and possibly in clinical trials to treat severe intestinal infections,” Fachi said. Another possibility will be to explore how different types and quantities of food fiber affect short-chain fatty acid production. “The composition of gut microbiota in the absence of IL-22BP can provide valuable information,” he added.

Gut microbiota modulation may benefit other intestinal inflammatory conditions, such as Crohn’s disease and ulcerative colitis, as well as infections caused by other pathogens.

“Finding out how IL-22 interacts with other molecules and immune system cells in the absence of IL-22BP will help us better understand its function in intestinal immunity. Future studies could transform our understanding of the role of these proteins in intestinal health and lead to the development of novel therapeutic strategies to prevent and treat intestinal infections,” Vinolo said.

Age ain’t nothing but a number, but ‘inflammatory age’ may be real.