Federal officials are disappointed to find that the monoclonal antibody drugs they’ve shipped across the country aren’t being used rapidly.
These drugs are designed to prevent people recently diagnosed with COVID-19 from ending up in the hospital. But hospitals are finding it cumbersome to use these medicines, which must be given by IV infusion. And some patients and doctors are lukewarm about drugs that have an uncertain benefit.
Doctors hope that as word gets out, more people will end up trying these drugs. They are provided to health systems free by the federal government, but it costs money to administer the medication. At first, Medicare set a price that would require many patients to pay a $60 copay, but the Centers for Medicare and Medicaid Services later found a way to waive that fee.
Summary: Artificial intelligence technology redesigned a bacterial protein that helps researchers track serotonin in the brain in real-time.
Source: NIH
Serotonin is a neurochemical that plays a critical role in the way the brain controls our thoughts and feelings. For example, many antidepressants are designed to alter serotonin signals sent between neurons.
“Once they are ingested, up to 90% of the plastic fragments that reach the intestine are excreted. However, one part is fragmented into nanoplastics which are capable, due to their small size and molecular properties, to penetrate the cells and cause harmful effects. The study establishes that alterations in food absorption have been described, as well as inflammatory reactions in the intestinal walls, changes in the composition and functioning of the gut microbiome, effects on the body’s metabolism and ability to produce, and lastly, alterations in immune responses. The article alerts about the possibility of a long-term exposure to plastic, accumulated throughout generations, could give way to unpredictable changes even in the very genome, as has been observed in some animal models.”
We live in a world invaded by plastic. Its role as a chemically stable, versatile and multi-purpose fostered its massive use, which has finally translated into our current situation of planetary pollution. Moreover, when plastic degrades it breaks into smaller micro and nanoparticles, becoming present in the water we drink, the air we breathe and almost everything we touch. That is how nanoplastics penetrate the organism and produce side effects.
A revised study led by the Universitat Autónoma de Barcelona (UAB), the CREAF and the Centre for Environmental and Marine Studies (CESAM) at the University of Aviero, Portugal, and published in the journal Science Bulletin, verifies that the nanoplastics affect the composition and diversity of our intestinal microbiome and that this can cause damage to our health. This effect can be seen in both vertebrates and invertebrates, and has been proved in situations in which the exposure is widespread and prolonged. Additionally, with alteration of the gut microbiome come alterations in the immune, endocrine and nervous system and therefore, although not enough is known about the specific physiological mechanisms, the study alerts that stress to the gut microbiome could alter the health of humans.
Preliminary results suggest anti-COVID19 nanobodies may be effective at preventing and diagnosing infections.
National Institutes of Health researchers have isolated a set of promising, tiny antibodies, or “nanobodies,” against SARS-CoV-2 that were produced by a llama named Cormac. Preliminary results published in Scientific Reports suggest that at least one of these nanobodies, called NIH-CoVnb-112, could prevent infections and detect virus particles by grabbing hold of SARS-CoV-2 spike proteins. In addition, the nanobody appeared to work equally well in either liquid or aerosol form, suggesting it could remain effective after inhalation. SARS-CoV-2 is the virus that causes COVID-19.
MANILA, Philippines — A Filipino startup is recognized globally in developing a dengue hotspot prediction system using satellite and climate data in the 2020 Group on Earth Observations Sustainable Development Goals (GEO SDG) Awards for the Sectoral category, For-Profit. The GEO SDG Awards recognize the productivity, ingenuity, proficiency, novelty, and exemplary communications of results and experiences in the use of Earth observations to support sustainable development.
CirroLytix Research Services was formed to create social impact through big data. Through the application of machine learning, data engineering, remote sensing, and social listening, the Philippines-based data analytics firm hopes to help governments, researchers, non-government organizations (NGO), and social enterprises achieve positive change. The Advanced Early Dengue Prediction and Exploration Service (Project AEDES) is one of the CirroLytix’s flagship projects developed during the 2019 National Aeronautics and Space Administration’s (NASA) International Space Apps Challenge. It combines digital, climate, and remote sensing to nowcast dengue trends and detect mosquito habitats to help pre-empt cases of dengue. Project AEDES process leverages normalized difference vegetation index (NDVI), Fraction of absorbed photosynthetically active radiation (FAPAR), and normalized difference water index (NDWI) readings from Landsat and Sentinel-2 to estimate still water areas on the ground, which is correlated with dengue case counts from national health centers.
The Advanced Early Dengue Prediction and Exploration Service (Project AEDES) combines digital, climate, and remote sensing to nowcast dengue trends and detect mosquito habitats to help pre-empt cases of dengue.
Dominic Vincent “Doc” Ligot, co-founder and chief technology officer of CirroLytix, describes Project AEDES as an “early detection of panics from online searches, anticipating case counts from environment readings, but most importantly pinpointing hotspots from mosquito habitat detection.”
The Pinoy-made dengue mapper tool won the annual international hackathon of NASA globally in the best use of data, the solution that best makes space data accessible, or leverages it to a unique application. Aside from winning last year, CirroLytix also developed an integrated public policy information portal measuring the impact of the coronavirus pandemic using Earth observation, in-country economic and human mobility data, and global infection case counts, thus winning again in the Space Apps COVID-19 Challenge for the same category in the best use of data. Named G.I.D.E.O.N. (Global Impact Detection from Emitted Light, Onset of COVID-19, and Nitrogen Dioxide), this dashboard for policy makers and economic planners shows the impact of COVID-19 on various countries and effects on the economy and environment.
Rusted iron pipes can react with residual disinfectants in drinking water distribution systems to produce carcinogenic hexavalent chromium in drinking water, reports a study by engineers at UC Riverside.
Chromium is a metal that occurs naturally in the soil and groundwater. Trace amounts of trivalent chromium eventually appear in the drinkingwater and food supply and are thought to have neutral effects on health. Chromium is often added to iron to make it more resistant to corrosion.
Certain chemical reactions can change chromium atoms into a hexavalent form that creates cancer-causing genetic mutations in cells. This carcinogenic form of chromium was at the heart of a lawsuit in California’s Central Valley by Erin Brockovich, which became the subject of an Oscar-winning movie.
ANCHORAGE, Alaska (Reuters) — A Fairbanks clinician suffered anaphylactic symptoms after being given the Pfizer Inc coronavirus vaccine, a hospital said on Friday, becoming the third Alaska health care worker to suffer an adverse reaction to the new drug. The clinician, whose name was not released, started showing symptoms about 10 minutes after being inoculated on Thursday, according to Foundation Health Partners, operator of the Fairbanks Memorial Hospital. The health care worker was treated in the hospital’s emergency room with epinephrine and released about six hours later, Foundation Health Partners said in a written statement. “Allergic reactions, though uncommon, can occur with injections of medications and vaccines,” Foundation Health Partners’ Chief Medical Officer Dr. Angelique Ramirez said in the statement.
“A reactogenic vaccine is not the same thing as an unsafe vaccine,” says Saad Omer, a vaccinologist and the director of the Yale Institute for Global Health.”
The COVID-19 vaccine will make some people feel sick. But they’re not—that’s the immune system doing its job.
As we sit here in 2020, in the middle of a major viral pandemic, we can’t forget the fact that a century after the first antibiotics were created, drug resistant bacterial infections have become a major threat around the globe, exactly at the same time that the antibiotic pipelines of pharma companies have either dried up, or they have gotten out of the business.
In the U.S. alone, Centers For Disease Control (CDC) estimates that antibiotic resistance causes more than 2 million infections, several million hospital stay days, and over 35, 000 deaths per year. Worldwide, such infections cause 750, 000 deaths every year. And a recent United Nations (UN) report concluded that by 2050, “super bugs” could kill 10 million people globally every year, if no action is taken to combat the problem.
Emerging and reemerging infections present an ever-increasing challenge to global health. Here, we report a nanoparticle-enabled smartphone (NES) system for rapid and sensitive virus detection. The virus is captured on a microchip and labeled with specifically designed platinum nanoprobes to induce gas bubble formation in the presence of hydrogen peroxide. The formed bubbles are controlled to make distinct visual patterns, allowing simple and sensitive virus detection using a convolutional neural network (CNN)-enabled smartphone system and without using any optical hardware smartphone attachment. We evaluated the developed CNN-NES for testing viruses such as hepatitis B virus (HBV), HCV, and Zika virus (ZIKV). The CNN-NES was tested with 134 ZIKV-and HBV-spiked and ZIKV-and HCV-infected patient plasma/serum samples. The sensitivity of the system in qualitatively detecting viral-infected samples with a clinically relevant virus concentration threshold of 250 copies/ml was 98.97% with a confidence interval of 94.39 to 99.97%.
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Smartphone systems can also benefit from the recent unprecedented advancements in nanotechnology to develop diagnostic approaches. Catalysis can be considered as one of the popular applications of nanoparticles because of their large surface-to-volume ratio and high surface energy (11–16). So far, numerous diagnostic platforms for cancer and infectious diseases have been developed by substituting enzymes, such as catalase, oxidase, and peroxidase with nanoparticle structures (17–20). Here, we adopted the intrinsic catalytic properties of platinum nanoparticles (PtNPs) for gas bubble formation to detect viruses on-chip using a convolutional neural network (CNN)–enabled smartphone system.
