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SARS-CoV-2 uses the SARS-CoV receptor ACE2 for host cell entry.

The spike protein of SARS-CoV-2 is primed by TMPRSS2.

Antibodies against SARS-CoV spike may offer some protection against SARS-CoV-2.


The emerging SARS-coronavirus 2 (SARS-CoV-2) threatens public health. Hoffmann and coworkers show that SARS-CoV-2 infection depends on the host cell factors ACE2 and TMPRSS2 and can be blocked by a clinically proven protease inhibitor. These findings might help to establish options for prevention and treatment.

By Bill D’Zio March 24, 2020 (Originally posted on www.westeastspace.com)

WestEastSpace mapped out NASA locations on a map of COVID19 impacted areas of USA from www.usafacts.org as of March 23rd, 2020With the launch window for NASA’s Mars Perseverance rover opening in a little less than four months, there are nearly daily pre-launch milestones to complete the rover pre flight activities at the Kennedy Space Center in Cape Canaveral, Florida. Tight schedules on complex missions usually do not mix well. Now NASA has to contend with another challenge. COVID19.

NASA Leadership Assessing Mission Impacts of Coronavirus

Covid-19 lasted for 17 days in the cabins of cruise ships:


Cruise ships are often settings for outbreaks of infectious diseases because of their closed environment and contact between travelers from many countries.

What is added by this report?

More than 800 cases of laboratory-confirmed COVID-19 cases occurred during outbreaks on three cruise ship voyages, and cases linked to several additional cruises have been reported across the United States. Transmission occurred across multiple voyages from ship to ship by crew members; both crew members and passengers were affected; 10 deaths associated with cruise ships have been reported to date.

The emergence of the novel coronavirus and its associated disease, COVID-19, has led to a global pandemic and a call for individuals, in the name of overall public health and an attempt to prevent national medical systems from being overwhelmed with too many patients at once, to self-isolate, self-quarantine, and practice social distancing. Many of us are confronted, for perhaps the only time in our lives, with an uncertain span of time in solitude.

Although this is the first time we’ve seen this particular phenomenon, social distancing isn’t a new invention. Humans have always had good reasons to withdraw from society, often for the greater good. Among the champions of isolation and social distancing are astronauts and cosmonauts—including the late Al Worden—whose time in space has often been spent in extended periods of cramped loneliness, away from family and friends. They can serve as inspiration in these difficult times.

As a cultural anthropologist, my research focuses on human behavior, particularly types of behavior shared by groups, and it is clear that social distancing is unusual. Human beings are gregarious creatures and we do tend to be found in “corporate bodies,” ranging from small bands of 30 to 50 people all the way up to huge cities filled with millions. In band societies, everyone knows everyone else and there’s generally shared work, shared play, and lots of shared gossip. In larger societies, where we may be surrounded by virtual strangers, celebrities seem to fill in as the people everyone knows, giving us membership in a community where celebrities are “shared points of reference” (Hermes and Kooijmann 2016). I may not know you well, but we can probably talk to each other about Sigourney Weaver and Tom Hanks.

As the COVID-19 cases continue to rise globally, the National Medical Products Administration of China has approved the first-ever antiviral medicine called Favilavir. This medicine is said to possibly treat the now-declared pandemic illness.

Over the weekend, Taizhou’s city government announced that Favilavir, which was initially formulated by a Chinese-owned pharmaceutical firm, is the first medicine authorized to stop the widespread of this fatal illness. At present, this drug is being promoted with the label, Avigan.

According to the Ministry of Science and Technology of China, the Favilavir of Hisun Pharmaceutical is among the three drugs that have presented results for hindering COVID-19 (in initial trials) from spreading and further damaging the health of the people worldwide.

Engineers have created a tiny device that can rapidly detect harmful bacteria in blood, allowing health care professionals to pinpoint the cause of potentially deadly infections and fight them with drugs.

The Rutgers coauthored study, led by researchers at Rochester Institute of Technology, is published in the journal ACS Applied Materials & Interfaces.

“The rapid identification of drug-resistant bacteria allows to prescribe the right drugs, boosting the chances of survival,” said coauthor Ruo-Qian (Roger) Wang, an assistant professor in the Department of Civil and Environmental Engineering in the School of Engineering at Rutgers University-New Brunswick.

A Covid-19 test can deliver results in less than an hour has been approved under an FDA emergency authorization, marking the first test that clinicians can use at the bedside.

Testing shortages have been an ongoing challenge in the U.S. response to curb the pandemic. The White House has promised testing will ramp up as more private companies come on board.

Public health and clinical labs have run more than 195,000 tests to date, but that doesn’t include hospital laboratories running their own test, Brett Giroir, assistant secretary for health at the U.S. Department of Health and Human Services, said during a White House briefing Saturday.

At least five downtown Denver hotels have closed temporarily to stem the coronavirus spread, and the statewide industry is bracing for a hit that could lead to as many as 72,000 job losses in a sector that produces a $13.4 billion annual gross domestic product statewide.

While only a handful of mountain resorts had shut down by early this week, that number has ballooned in recent days as hotels across the metro region are reporting vacancy levels below 10% during a month many had predicted would be record-setting, Colorado Hotel and Lodging Association President/CEO Amie Mayhew said. Among those that have announced they will shutter until May 11 or 12 are the Grand Hyatt Denver, the Oxford Hotel, the Crawford Hotel and The Maven Hotel at Dairy Block.

All of those except for the Grand Hyatt are operated by Sage Hospitality Group of Denver, whose CEO, Walter Isenberg, issued a letter Thursday saying he’d made “the very difficult decision to temporarily suspend business operations at a portion of our hotels and restaurants in order to protect the health and safety of our guests, our associates and our communities.”

Dr. Ezekiel Emanuel, an American oncologist and bioethicist who is senior fellow at the Center for American Progress as well as Vice Provost for Global Initiatives at the University of Pennsylvania and chair of the Department of Medical Ethics and Health Policy, said on MSNBC on Friday, March 20, that Tesla and SpaceX CEO Elon Musk told him it would probably take 8–10 weeks to get ventilator production started at his factories (he’s working on this at Tesla and SpaceX).

I reached out to Musk for clarification on that topic and he replied that, “We have 250k N95 masks. Aiming to start distributing those to hospitals tomorrow night. Should have over 1000 ventilators by next week.” With medical supplies such as these being one of the biggest bottlenecks and challenges at the moment in the COVID-19 response in the United States (as well as elsewhere) — something that is already having a very real effect on medical professionals and patient care — the support will surely be received with much gratitude. That said, while there has been much attention put on the expected future need for ventilators, very few places reportedly have a shortage of them right now. In much greater need at the moment are simpler supplies like N95 masks, which must be why Tesla/SpaceX is providing 250,000 of them.

Dr. Emanuel also said in the segment of MSNBC’s “Morning Joe” he was on that we probably need 8–12 weeks (2–3 months) of social distancing in the US in order to deal with COVID-19 as a society. However, he also expects that the virus will come back and we’ll basically have a roller coaster of “social restrictions, easing up, social restrictions, easing up … to try to smooth out the demand on the health care system.”