A superb and fun interview with Dr Michael Fossel and why he believes telomerase therapy is the most direct route to dealing with aging.
OK. In scientific terms, it is only a ‘hypothesis’ — the reverse of the ‘Disposable Soma’ theory of ageing. Here how it goes.
For the past several decades, the Disposable Soma theory of ageing has been enjoying good publicity and a lively interest from both academics and the public alike. It stands up to scientific scrutiny, makes conceptual sense and fits well within an evolutionary framework of ageing. The theory basically suggests that, due to energy resource constraints, there is a trade-off between somatic cell and germ cell repair. As a result, germ cells are being repaired effectively and so the survival of the species is assured, at a cost of individual somatic (bodily) ageing and death. To put it very simply, we are disposable, we age and die because all the effective repair mechanisms have been diverted to our germ cell DNA in order to guarantee the survival of our species.
The theory accounts for many repair pathways and mechanisms converging upon the germ cell, and also for many of those mechanisms being driven away from somatic cell repair just to ensure germ cell survival. In the past two or three years however, it is increasingly being realised that this process is not unidirectional (from soma to germ), but it is bi-directional: under certain circumstances, somatic cells may initiate damage that affects germ cells, and also that germ cells may initiate repairs that benefit somatic cells!
I can’t even begin to describe how important this bi-directionality is. Taking this in a wider and more speculative sense, it is, in fact, the basis for the cure of ageing. The discovery that germ cells can (or are forced to) relinquish their repair priorities, and that resources can then be re-allocated for somatic repairs instead, means that we may be able to avoid age-related damage (because this would be repaired with greater fidelity) and, at the same time, avoid overpopulation (as our now damaged genetic material would be unsuitable for reproduction).
Continue reading “The ‘Indispensable Soma’ theory of ageing” »
Interest in Nootropics has grown exponentially over recent years within the health conscious communities and is still a trend moving upwards as I write this. Nootropics are essentially smart drugs that can be bought over the counter or online at retail prices below $50. The majority of Nootropics are cognitive enhancers, that is they are…
“OS FERMENTATION events have included installations, workshops, prints, and tastings. The installation includes digital prints created by custom electronics and software that allow microbes to take their own “selfies” and add image manipulation effects to their images based on the shifting pH levels, oxygen, and color values of the fermentation process.”
“When resources are scarce, a species as a whole has a better shot at surviving if its populations are organizing themselves to promote long term survival with shorter individual lifespans. They are evolving to combat overpopulation and overconsumption, basically…humans could be living a lot longer than they do now—we have, after all, inherited a lifespan from times when our forebears were eking out an existence as scrappy hunter gatherers” Read more
“The Biological Technologies Office (BTO), which opened in April 2014, aims to support extremely ambitious — some say fantastical — technologies ranging from powered exoskeletons for soldiers to brain implants that can control mental disorders. DARPA’s plan for tackling such projects is being carried out in the same frenetic style that has defined the agency’s research in other fields.” Read more
When I hear that the conversation is about an ethical problem I anticipate that right now the people are going to put everything upside down and end with common sense. Appealing to ethics has always been the weapon of conservatism, the last resort of imbecility.
How does it work? At the beginning you have some ideas, but in the end it’s always a “no”. The person speaking on the behalf of ethics or bioethics is always against the progress, because he or she is being based on their own conjectures. What if the GMO foods will crawl out of the garden beds and eat us all? What if there will be inequality when some will use genetic engineering for their kids and some won’t? Let’s then close down the schools and universities – the main source of inequality. What if some will get the education and other won’t?
That’s exactly the position that Elon Musk took by fearing the advances in genetic engineering. Well, first of all, there already is plenty of inequality. It is mediated by social system, limited resources and genetic diversity. First of all, why should we strive for total equality? More precisely, why does the plank of equality has to be based on a low intellectual level? How bad is a world where the majority of people are scientists? How bad is a world where people live thousands of years and explore deep space? It’s actually genetic engineering that gives us these chances. From the #ethics point of view things are visa versa. It’s refusing the very possibility of helping people is a terrible deed. Let’s not improve a person, because if we do what if this person becomes better than everybody else? Let’s not treat this person, because if we do he might live longer than everybody else? Isn’t this complete nonsense?
Continue reading “It is Unethical Not to Use Genetic Engineering” »
A balanced article on transhumanism and the future in a trendy Hong Kong & Chinese men’s lifestyle magazine. Article in English:
The idea is simple. First, they take an arm from a dead rat and put it through a process of decellularization using detergents. This leaves behind a white scaffold. The scaffold is key because no artificial reconstructions come close to replicating the intricacies of a natural one.
On a snowy evening in Brooklyn, New York, sweat is streaming from my pores, rolling down my face, back, and palms. I don’t know what the temperature is here inside the MRI machine, but “summer in the Sahara” seems about right. I keep thinking about how I should have shed my winter-weight pants and button-down shirt.
The lab technician chimes in over a microphone. He reminds me not to move or I’ll need to start the MRI over. Considering I’ve been here for 45 minutes, that doesn’t sound appealing. My eyes sting, and sweat has pooled in weird places. I imagine this is what Chinese water torture feels like. Add to that, I have a gadolinium contrast agent coursing through my body. The substance is supposed to highlight areas of inflammation, but it can also make you feel like you’re itching from within. Read more
