Lifeboat Foundation

A study of more than 8 million adults in Ontario, Canada suggests that even a modest loss of kidney function is associated with increased health risks. The study, published in The BMJ, could lead to better approaches to prevent chronic kidney disease and related conditions, particularly in younger adults.

“The dogma is that healthy, young adults don’t need to worry about kidney function unless it drops to around 50% of the normal level, but our research suggests that even a more modest 20–30% drop may have consequences and we may want to have earlier conversations about prevention and monitoring,” said senior author Dr. Manish Sood, senior scientist, nephrologist and Jindal Research Chair for the Prevention of Kidney Disease at The Ottawa Hospital and professor at the University of Ottawa.

The research team examined ICES health record data from 2008 to 2021 for every Ontario adult aged 18–65 who had at least one blood test for kidney function, but no history of kidney disease. They found that 18% of those in the 18–39 age group had kidney function that was modestly below normal levels, but not low enough to be diagnosed with chronic kidney disease. Individuals in this “gray zone” faced a modestly increased risk of kidney failure, death and cardiovascular events such as heart attack.

Four volunteers are about to enter a simulated Mars habitat where they’ll spend the next 378 days as part of ongoing preparations for the first crewed mission to the faraway planet.

The specially designed, enclosed habitat at NASA’s Johnson Space Center in Houston, Texas, will host Alyssa Shannon, Ross Brockwell, Kelly Haston, and Nathan Jones from Sunday, June 25. The team’s experience spans science, engineering, and health, and each member will use their specific skills during their stay.

The mission will be the first of three one-year Mars surface simulations, called CHAPEA (Crew Health and Performance Exploration Analog).

Making the yogurt of the future requires a cast of 21st-century helpers: machine learning, gut science and even a mysterious artificial stomach.

At a new Danone facility near Paris, researchers feed dollops of yogurt into globular glass vessels and plastic tubes designed to mimic the human gut. Once the bacteria inside show they can survive the digestive juices, artificial intelligence is put to work to probe their potential health benefits.

To consumers bombarded with claims about the supposed power of probiotics, the goal may sound familiar: souped-up yogurt. But the owner of Activia and Actimel is betting technology can yield answers on which friendly bacteria work best and why, giving its products a scientific edge at a time when revenue is lagging and consumers are growing wary of processed food.

A new study shows how space travel may modify the gene expression in white blood cells (WBCs), which fight infections.

Beyond Earth, a less gravity environment poses a significant risk to the health of astronauts, particularly during longer-duration missions.

Understanding how the human body reacts to the space environment is crucial for the long term and designing countermeasures to protect astronauts’ health.

People who owned black-and-white television sets until the 1980s didn’t know what they were missing until they got a color TV. A similar switch could happen in the world of genomics as researchers at the Berlin Institute of Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB) have developed a technique called Genome Architecture Mapping (“GAM”) to peer into the genome and see it in glorious technicolor. GAM reveals information about the genome’s spatial architecture that is invisible to scientists using solely Hi-C, a workhorse tool developed in 2009 to study DNA interactions, reports a new study in Nature Methods by the Pombo lab.

“With a black-and-white TV, you can see the shapes but everything looks gray,” says Professor Ana Pombo, a molecular biologist and head of the Epigenetic Regulation and Chromatin Architecture lab. “But if you have a color TV and look at flowers, you realize that they are red, yellow and white and we were unaware of it. Similarly, there’s also information in the way the genome is folded in three-dimensions that we have not been aware of.”

Understanding DNA organization can reveal the basis of health and disease. Our cells pack a 2-meter-long genome into a roughly 10 micrometer-diameter nucleus. The packaging is done precisely so that regulatory DNA comes in contact with the right genes at the right times and turns them on and off. Changes to the three-dimensional configuration can disrupt this process and cause disease.

Nima Majlesi, director of Medical Toxicology at Staten Island University Hospital, also not part of the research, said the new study is “fascinating, and the more research that can be done on neurodegenerative diseases such as [Alzheimer’s disease], the more answers that can then be obtained for the betterment of everyone’s health.”

“There has never been any doubt that excessive alcohol use and recurrent intoxication [are] unhealthy in the medical community. There has occasionally been some doubt on whether a small amount of alcohol use daily can have health benefits. Even in patients not at risk for [Alzheimer’s disease], excessive alcohol use and recurrent intoxication [have] many detrimental effects on human health.” — Dr. Nima Majlesi

However, Dr. Majlesi cautioned that “in this study, they exposed mice to ethanol vapors, which is not the typical route for human consumption.”

Hospitals and cancer centers are running out of two major injectable cancer drugs: carboplatin and cisplatin. Dr. Eleonora Teplinsky, head of breast medical oncology for the Valley Health System in New Jersey, joins Ali Rogin to discuss the causes and effects of the shortages, and the dilemmas that providers and their patients now face.

Researchers from the Gothelf lab at Aarhus University.

Established in Aarhus, Denmark in 1928, Aarhus University (AU) is the largest and second oldest research university in Denmark. It comprises four faculties in Arts, Science and Technology, Health, and Business and Social Sciences and has a total of 27 departments. (Danish: Aarhus Universitet.)

Circa 2020

Imagine a dressing that releases antibiotics on demand and absorbs excessive wound exudate at the same time. Researchers at Eindhoven University of Technology hope to achieve just that, by developing a smart coating that actively releases and absorbs multiple fluids, triggered by a radio signal. This material is not only beneficial for the health care industry, it is also very promising in the field of robotics or even virtual reality.

Continue reading “Artificial skin heals wounds and makes robots sweat” »