While scientists around the world pursue ways to extend the human healthspan, cancer cells have found a way to become immortal.
For the first time, researchers have discovered how one type of cancer – melanoma – achieves that immortality.
New video: Dr. Aaron Cravens, CEO of Revel Pharmaceuticals at #RejuvenationStartupSummit 2022 about developing designer enzymes to treat diseases of aging, e.g. glucosepane crosslink breakers to prevent hardening of tissues such as muscle, skin, and arteries leading to increased blood pressure, vascular damage, and wrinkling of the skin.
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Structuring, Financing & Growing Novel Longevity Ventures — Dr. Tobias Reichmuth Ph.D., Founding Partner, Maximon
Dr. Tobias Reichmuth, Ph.D. is Founding Partner at Maximon (https://www.maximon.com/), The Longevity Company Builder, which empowers entrepreneurs to build impactful, science-based and scalable companies providing healthy aging and rejuvenation solutions.
I don’t think immortality is possible because everything has it’s end.with with proper research in medical science life expectancy can be increased.
The pursuit of immortality is getting older. So are we.
Year 2020 face_with_colon_three
An international team of scientists have restored the vision in blind rats using a nanoparticle-based artificial retina prosthesis that can be injected directly into the eye. The scientific advance has been successfully demonstrated for a period of eight months without the need for surgery. While it is still early days for the research, it suggests it might one day be possible to use the conjugated polymer nanoparticle (P3HT-NP) treatment in humans to correct eye problems –ranging from hereditary retinal dystrophies to the incredibly common age-related macular degeneration.
“In our ‘liquid retina device,’ P3HT nanoparticles spread out over the entire subretinal space and promoted light-dependent activation of spared inner retinal neurons, recovering subcortical, cortical and behavioral visual responses,” Fabio Benfenati, research director at the Italian Institute of Technology, told Digital Trends. “We think that P3HT-NPs provide a new avenue in retinal prosthetics.”
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Year 2021 face_with_colon_three
Xenobots, a type of programmable organism made from frog cells, can replicate by spontaneously sweeping up loose stem cells, researchers say. This could have implications for regenerative medicine.
The BACE1 enzyme has a rate-limiting role in the amyloidogenic pathway (see Glossary) and has been extensively studied for its neuronal functions[1]. Since 2000, intensive efforts have focused on developing small-molecule BACE1 inhibitors to reduce amyloid β (Aβ) production in Alzheimer’s disease (AD) brains. However, human clinical trials involving most BACE1 inhibitors were stopped at Phase 2/3 due to limited therapeutic benefits[2]. BACE1 inhibitors act by reducing Aβ-related pathologies in AD brains, that is, they are used to treat the symptoms rather than the underlying disease.
Summary: Researchers engineered cells containing customized adhesion molecules that bind to specific cell partners in predictable ways to form complex multicellular entities. The discovery is a major step toward building new tissue and organs.
Source: UCSF
Researchers at UC San Francisco (UCSF) have engineered molecules that act like “cellular glue,” allowing them to direct in precise fashion how cells bond with each other. The discovery represents a major step toward building tissues and organs, a long-sought goal of regenerative medicine.
Achieving a long-sought goal of regenerative medicine.
Researchers from the University of California, San Francisco, (UCSF) engineered molecules that function as “cellular glue,” enabling them to precisely direct how cells bond with each other. This is a significant step toward regenerative medicine’s long-term goal of creating new tissues and organs, according to a press release.
Adhesive molecules are naturally present in the body and keep the tens of trillions of cells together in organized patterns. They build neural networks, develop structures, and direct immune cells to specific areas of the body. Adhesion also makes cell communication easier to maintain the body functioning as a self-regulating whole.
