Not a dramatic increase, but a good one.
Loyal, a US biotech startup, has been conducting research and development on LOY-002, a potential drug for extending the lifespan of dogs.
The Guardian reported that the company expects to launch this beef-flavored pill on the market early next year.
Interestingly, Loyal believes their research on canine longevity will also benefit humans.
The multistep process by which phagocytes engulf these deceased cells without eliciting an inflammatory response is called efferocytosis. Despite significant insights into the fundamental mechanisms of efferocytosis, its implications in disorders such as aging and cancer remain elusive. Upon summarizing and analyzing existing studies on efferocytosis, it becomes evident that efferocytosis is our friend in resolving inflammation, yet it transforms into our foe by facilitating tumor development and metastasis. This review illuminates recent discoveries regarding the emerging mechanisms of efferocytosis in clearing apoptotic cells, explores its connections with aging, examines its influence on tumor development and metastasis, and identifies the regulatory factors of efferocytosis within the tumor microenvironment. A comprehensive understanding of these efferocytosis facets offers insights into crucial physiological and pathophysiological processes, paving the way for innovative therapeutic approaches to combat aging and cancer.
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Researchers at the Allen Institute have identified a specific brain region in mice where aging triggers significant changes in numerous cell types. The study also pinpointed which cell types undergo the most profound transformations.
This new information, published in the journal Nature, points toward potential approaches for slowing or controlling the aging process in the brain.
The research was focused on numerous glial cell types – the brain’s “support cells” – that demonstrated considerable shifts in gene activity with age. Among the cells most affected were microglia, border-associated macrophages, oligodendrocytes, tanycytes, and ependymal cells.
In this documentary, wealthy entrepreneur Bryan Johnson puts his body and fortune on the line to defy aging and extend his life beyond all known limits.
“The ultimate goal is to extend healthspan—meaning the number of years aging adults live healthy lives and enjoy overall well-being by compressing the frailty and disability that comes with aging into a shorter duration of time near the end of life,” says Andrew Brack, PhD, the PROSPR Program Manager.
The new venture will be building on some of the work that the National Institute of Aging (NIH) has been working on and will be working in collaboration with various organizations in the biotechnology industry as well as some unspecified regulators to accelerate the development, testing, and availability of new therapeutic that targets human healthspan.
It is hoped that the new initiative, along with positively impacting the healthspan of Americans, will also help to enhance the economy across the nation.
Largest brain aging study points to possible connections between diet, inflammation, and brain health.
Scientists at the Allen Institute have discovered specific types of brain cells in mice that experience significant changes as they age. They also identified a distinct “hotspot” where many of these changes are concentrated. Published today (January 1) in Nature, these findings could lead to the development of therapies aimed at slowing or managing the brain’s aging process.
Sensitive cells: Scientists discovered dozens of specific cell types, mostly glial cells, known as brain support cells, that underwent significant gene expression changes with age. Those strongly affected included microglia and border-associated macrophages, oligodendrocytes, tanycytes, and ependymal cells.
Inflammation and neuron protection: In aging brains, genes associated with inflammation increased in activity while those related to neuronal structure and function decreased.
Aging hot spot: Scientists discovered a specific hot spot combining both the decrease in neuronal function and the increase in inflammation in the hypothalamus. The most significant gene expression changes were found in cell types near the third ventricle of the hypothalamus, including tanycytes, ependymal cells, and neurons known for their role in food intake, energy homeostasis, metabolism, and how our bodies use nutrients. This points to a possible connection between diet, lifestyle factors, brain aging, and changes that can influence our susceptibility to age-related brain disorders.
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice.
A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional changes and the interaction of ageing and disease.
Scientists at the Allen Institute have identified specific cell types in the brain of mice that undergo major changes as they age, along with a specific hot spot where many of those changes occur. The discoveries, published in the journal Nature, could pave the way for future therapies to slow or manage the aging process in the brain.
The scientists discovered dozens of specific cell types, mostly glial cells, known as brain support cells, that underwent significant gene expression changes with age. Those strongly affected included microglia and border-associated macrophages, oligodendrocytes, tanycytes, and ependymal cells.
They found that in aging brains, genes associated with inflammation increased in activity while those related to neuronal structure and function decreased.
Researchers have developed a method to direct stem cells to form specific structures. By triggering the expression of specific genes in mouse embryonic stem cells, synthetic organizer cells were created, which can assemble in specific ways and carry out various phsyiological functions. This work is an important step on the road to eventually using synthetic cells to repair damaged tissues or regenerate organs. The research has been reported in Cell.
The researchers created synthetic organizer cells that could generate a structure like a mouse body, from head to tail, that underwent processes that were similar to those in mouse embryonic development. Another type of synthetic organizer cell was used to produce a structure that was similar to a heart, and featured a central chamber. This synthetic, heart-like structure also had a network of blood vessels and beat regularly.
