Lifeboat Foundation

Histopathology describes the process of examining pieces of tissue using a microscope. Light microscopic (LM) examination of tissue helps diagnose several types of cancer by allowing pathologists to view cellular changes within a biopsy sample.

The workload of pathologists has increased in recent years due to policies that encourage screening for early cancer diagnoses. In addition, longer life expectancies and scientific advances have led to an increased number of cancer survivors, further increasing the need for pathology evaluations. Thus, strategies to efficiently utilize the limited pathology resources have become essential to maintaining standards of care and the health and safety of patients.

Digital pathology (DP) has emerged as an alternative method for analyzing tissue samples by stitching together digital images from histopathology slides. Automated slide scanners can rapidly generate these high-resolution images with minimal human interaction. In addition to the speed, DP does not require a microscope, offering remote viewing possibilities. Pathologists and other healthcare professionals can easily share images.

— Anti-aging vaccine shows promise in mice — will it work in humans?

“This research is still in the early stages and may be a number of years from being available to patients,” Dr. David Pinato, a clinician scientist at Imperial College London’s Department of Surgery & Cancer and a consultant medical oncologist at Imperial College Healthcare NHS Trust, said in the statement. “But this trial is laying crucial groundwork that is moving us closer towards new therapies that are potentially less toxic and more precise.”

The first person treated in the U.K. arm of the trial wishes to remain anonymous, but said “I was pleased to be offered a chance to take part in a new trial.”

We’ve updated our list of the best longevity experts on Twitter/X and added 8 new accounts, including Dr. Morgan Levine, Dr. Brad Stanfield, and the research journal Nature Aging!

Best known for his popular longevity YouTube channel, Stanfield is a medical doctor with an interest in longevity science. Like some other folks on this list of longevity influencers, Stanfield can be a bit iconoclastic, challenging orthodoxy on things like resveratrol and fisetin.

Just like in his well-sourced videos, Stanfield’s Twitter feed is heavy with links to research papers and studies on longevity-related topics, from recent mouse studies out of the Interventions Testing Program, to threads on diet based on new trials. The downside is in his Twitter feed you don’t get to hear that sweet Kiwi accent you get from his videos.

Followers: 24,000

Continue reading “21 Best Longevity Experts and Influencers on Twitter/X” »

I’m excited to share my latest Opinion article on AI at The Hill, a top political site/paper read by the White House and Congress:

Regardless what politicians promise, this age of AI and robots will also affect the size and growth rates of the U.S. government. Federal and state government may not immediately take up with automation and AI to the extent the private sector does, but eventually the stark rationality of lower overhead expenses—and thus lower taxes for citizens—will prevail.

This is a good thing. A smaller, nimble, more efficient government will benefit the majority of people.

Continue reading “AI can stop government from growing, and that’s a good thing” »

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Ecstadelic GPT, powered by GPT-4, is pioneering the frontier of AI-assisted understanding of Biohacking, Anti-Aging, Superlongevity, Wellness, Technohedonism, SuperWellbeing, Personal Development, Self-Transcendence, Transhumanism.

A study at the University of Cologne’s CECAD Cluster of Excellence in Aging Research has identified a protein complex that is activated by defects in the spliceosome, the molecular scissors that process genetic information. Future research could lead to new therapeutic approaches to treat diseases caused by faulty splicing.

The genetic material, in the form of DNA, contains the information that is crucial for the correct functioning of every human and animal cell. From this information repository, RNA, an intermediate between DNA and protein, the functional unit of the cell, is generated. During this process, the genetic information must be tailored for specific cell functions. Information that is not needed (introns) is cut out of the RNA and the important components for proteins (exons) are preserved.

A team of researchers led by Professor Dr. Mirka Uhlirova at the University of Cologne’s CECAD Cluster of Excellence in Aging Research has now discovered that if the processing of this information no longer works properly, a protein complex (C/EBP heterodimer) is activated and directs the cell towards a dormant state, known as cellular senescence. The results appear under the title “Xrp1 governs the stress response program to spliceosome dysfunction” in Nucleic Acids Research.

A preventative anti-aging therapy seems like wishful thinking.

Yet a new study led by Dr. Corina Amor Vegas at Cold Spring Harbor Laboratory describes a treatment that brings the dream to life—at least for mice. Given a single injection in young adulthood, they aged more slowly compared to their peers.

By the equivalent of roughly 65 years of age in humans, the mice were slimmer, could better regulate blood sugar and insulin levels, and had lower inflammation and a more youthful metabolic profile. They even kept up their love for running, whereas untreated seniors turned into couch potatoes.

Ageing, as you might expect, had a big impact on participants’ feelings of loneliness. The deaths of partners and loved ones was particularly difficult, while participants also commented on how loss of mobility restricted their social activities. Social skills were also identified as a risk factor: one participant noted that those without strong social skills may be more likely to suffer.

Emotionally, loneliness was (unsurprisingly) connected to feelings of emptiness, sadness and lack of meaning. One participant described herself as feeling “lost… and not having control, and sometimes it can lead you to not be able to make decisions and then it just gets worse”, whilst another described loneliness as “the feeling of nothing”

But many participants also commented on strategies they used to protect against loneliness. Though ageing was a risk factor, acceptance of ageing had more positive outcomes. As one participant put it: “I used to mountain climb… If I can’t walk anymore, I’ll crawl. You have to learn how to be realistic and not brood about it. I know I’m getting older, but I consider life a transition.” Compassion was also useful: being proactive about helping others, for example, helped some participants prevent being lonely.