Lifeboat Foundation

A team of Massachusetts General Hospital (MGH) investigators has made the first steps towards development of bioartificial replacement limbs suitable for transplantation They had used decellularization technique to regenerate kidneys, livers, hearts and lungs from animal models, but this is the first reported use to engineer the more complex tissues of a bioartificial limb.

They took the leg from recently deceased rat and then:

* Over a period of 52 hours, infusion of a detergent solution removes cells from a rat forelimb, leaving behind the cell-free matrix scaffolding onto which new tissues can be regenerated.

Continue reading “Next Big Future: Conceptually Viable Brute Force Radical Life Extension” »

Curing aging has 4 stages: mild aging deceleration, dramatic aging deceleration, achieving negligible senescence and rejuvenation. Today we can definitively claim that the task of mild aging deceleration is theoretically solved.

We know the drugs and interventions that slow down aging in mammals. The only thing that we don’t know is dosages, regimes and drug combinations. Defining all of that is the goal of pre-clinical and clinical studies. They can be started immediately. It is also a good idea to do clinical studies of various diets aimed at improving human longevity.

Dramatic aging deceleration will be achieved using gene therapy. Breakthrough studies of lifespan extension in old model animals happened in this area quite recently. We know the genes and delivery methods, now we need a set of powerful experiments aimed at radical life extension. The subject of the intervention will not only be the human genome, but the genomes of the human microbiota.

Continue reading “Fours Stages of Curing Aging” »

A long interview from Esquire on transhumanism, AI, life extension, my campaign, and thoughts on the future.

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New story in The Huffington Post on transhumanism, life extension, and overcoming deathist culture:

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“The Howard Hughes Medical Institute (HHMI) announced today that 26 of the nation’s top biomedical researchers will become HHMI investigators and will receive the flexible support necessary to move their research in creative new directions. The initiative represents an investment in basic biomedical research of $153 million over the next five years.”

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Harnessing “Black Holes”: The Large Hadron Collider – Ultimate Weapon of Mass Destruction

Why the LHC must be shut down

Continue reading “CERN-Critics: LHC restart is a sad day for science and humanity!” »

Vicki Turk & Brian Anderson | Motherboard
“That’s another basic thing that the doom-and-gloom, death-is-preferable-to-the-future crowd seem to misunderstand. The world won’t just stay the same, with everyone trudging along in a state of boredom; it’ll keep changing. There’ll be new stuff to do because we’ll keep making new stuff. We’ll get those jetpacks we were promised, and that’s just the start.” Read more

By Levi Sumagaysay — siliconbeat

“When I am successful in realizing this mega-project, then I will finally have 10,000 years for numerous hobbies.”

— Dmitry Itskov, founder of the 2045 Initiative, which aims to transfer our brains and human consciousness to robot avatars instead of bodies that weaken and die. Itskov is a billionaire who’s known as the godfather of the Russian Internet. He also apparently has plenty of hobbies.

Think tech isn’t working on big problems? Newsweek checks on the progress of the 2045 Initiative and other efforts — including in Silicon Valley — to cheat death. The efforts are funded by other deep-pocketed titans of tech: Peter Thiel of PayPal fame has given money to the Methuselah Foundation, which is working to find drugs that cure age-related damage to the body’s cells. Oracle founder Larry Ellison’s Ellison Medical Foundation distributes grants to those who are researching aging. As we’ve written, Google spinoff Calico‘s stated mission is to “harness advanced technologies to increase our understanding of the biology that controls lifespan.” Google’s Larry Page has also backed Singularity University; co-founders Ray Kurzweil and Peter Diamandis are big fans of immortality — or at least living till 700.

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