Lifeboat Foundation

A new research paper was published by Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) in Volume 15, Issue 15, entitled, “Associations between klotho and telomere biology in high stress caregivers.”

Aging biomarkers may be related to each other through direct co-regulation and/or through being regulated by common processes associated with chronological aging or stress. Klotho is an aging regulator that acts as a circulating hormone with critical involvement in regulating insulin signaling, phosphate homeostasis, oxidative stress, and age-related inflammatory functioning.

In this new study, researchers Ryan L. Brown, Elissa E. Epel, Jue Lin, Dena B. Dubal, and Aric A. Prather from the Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, Department of Biochemistry and Biophysics, University of California, San Francisco, and the Department of Neurology and Weill Institute of Neurosciences, University of California, San Francisco discuss the association between klotho levels and telomere length of specific sorted immune cells among a healthy sample of mothers caregiving for a child with autism spectrum disorder (ASD) or a child without ASD — covarying age and body mass index — in order to understand if high stress associated with caregiving for a child with an ASD may be involved in any association between these aging biomarkers.

O.o!!! The longevity of this complex organism could reveal new avenues for immortality.

Arenaerpeton supinatus was discovered in rocks cut from a nearby quarry that were intended for the building of a garden wall.

A 240-million-year-old fossil of an amphibian was found in a retaining wall in the 1990s. This significant find has now been formally named and described by scientists at the University of New South Wales (UNSW Sydney) and the Australian Museum.

Continue reading “240-Million-Year-Old Giant Amphibian Discovered in Retaining Wall” »

We all know having a balanced diet is important to stay healthy. New research from Waseda University has started to unpick the optimum proportion of macronutrients for a diet that supports metabolic health as we age – starting with protein. The study is published in GeroScience.

Linking diet to “healthspan”

Over our lifespans, our nutrition needs change. By optimizing our diets according to what our bodies need (in relation to our age), we can maintain our metabolic health and thereby increase our “healthspan”, with healthspan referring to the length of time in our lives that we spend in good health.

These clocks promise to measure biological age and help identify anti-aging drugs, but there are lingering questions over their accuracy.

Brain age was estimated using an algorithm that combined multiple measures of brain structure obtained through MRI scans when the participants were 45 years old. This algorithm quantified the difference between estimated brain age and the participants’ chronological age, referred to as brain age gap estimate.

If the estimated brain age is higher than the chronological age, it suggests that the brain’s structural characteristics are more similar to those of an older individual. Conversely, if the estimated brain age is lower than the chronological age, the brain’s structural characteristics resemble those of a younger individual.

Lay-Yee and his colleagues also adjusted their analyses for various potential confounding factors. These included socio-demographic factors like sex and socio-economic status, as well as family factors (teen-aged mother, single parent, change in residence, maltreatment) and child-behavioral factors (self-control, worry/fearfulness).

The authors used a long-read nanopore method to study chromatin accessibility and DNA methylation of the highly repetitive centromeres, telomeres, and ribosomal DNA arrays in both wildtype and DNA methylation mutants of Arabidopsis.

I will try to live as long as possible.

Dr. Ezekiel Emanuel plans to reject life-extending medical care at the age of 75. The reason he does this is quite similar to why the Kaelons commit ritual suicide in Star Trek: The Next Generation. Does this make sense?

Continue reading “How Long Should You Live? Star Trek, Dr. Emanuel, & The Ethics of Life Extension” »

This is a SURVEY result of Rapamycin users. Overall, it’s really good for you. It has not had a true trial as it is off-patent so it’s harder to get rich from it. Low dose use has minimal side effects if any at all. Many patients can get off-label prescription from their doctor.

Magnesium Breakthrough 10% Discount _https://bit.ly/3O5tPfu_ Code Modern10 This video brought to you by BiOptimizers.
Here Prof Kaeberlein provides some updates on rapamycin, in particular the results from the survey based trial that his team ran and thoughts on next steps for the supplement.

Continue reading “Rapamycin Update What You Need To Know | Prof Matt Kaeberlein Ep1” »

DISCLOSURE: Longevity. Technology (a brand of First Longevity Limited) has been contracted by the company featured in this article to support its current funding round. Qualifying investors can find out more via the Longevity. Technology investor portal.

This week’s Longevity Summit Dublin is in full swing, bringing together experts from around the world, fostering collaboration and knowledge exchange in the pursuit of solutions to extend human healthspan. One of the speakers during today’s sessions was Stanford professor and surgeon, Dr Vinit Mahajan, who is also Chief Medical Advisor for longevity biotech startup Mitrix Bio.

In his address to summit delegates in Dublin, Mahajan presented the company’s fascinating preclinical technology: bioreactor-grown mitochondria designed to be transplanted into the human body to regenerate organs, reverse age-related disease, and support other longevity therapies.