The psychedelic compound psilocybin has played a role in hominid lives and perceptions for millions of years.
Category: neuroscience – Page 141
Ever since sharing Ned Block’s talk on it, phenomenal consciousness has been on my mind. This week, I decided I needed to go back to the main spokesperson for the issue of subjective experience, David Chalmers, and his seminal paper Facing Up to the Problem of Consciousness.
I have to admit I’ve skimmed this paper numerous times, but always struggled after the main thesis. This time I soldiered on in a more focused manner, and was surprised by how much I agreed with him on many points.
Chalmers starts off by acknowledging the scientifically approachable aspects of the problem.
By Douglas Whitbread via SWNS
Footage shows a Parkinson’s sufferer’s “life-changing” transformation after taking a new wonder treatment — for just one week.
Damian Gath, 52, who previously went to the gym four times a week, was diagnosed with the incurable brain condition — which causes involuntary shaking — ten years ago.
Dive into our latest feature that unveils the seamless melding of the human mind with sophisticated technology. Witness how brain-machine interfaces are setting the stage for a revolution in how we interact with the digital world.
A brain-computer interface from the startup Inbrain could be used to treat Parkinson’s disease.
Dr John Marshall is a leading neuroscientist and a pioneer in the signalling and synaptic trafficking fields, and has made major contributions to understanding brain injury and neurodevelopmental disorders. He received his MSc from the University of Toronto and completed his PhD training in Neurobiology at the MRC at Cambridge University, England. He worked with Professor Len Kaczmarek at Yale University. Marshall assumed his position at Brown University in 1995 and has continued to produce cutting-edge research. His lab focus is on memory and behaviour in rodent models of Angelman syndrome.
Contact Details
Recently, human brain organoids have raised increasing interest from scholars of many fields and a dynamic discussion in bioethics is ongoing. There is a serious concern that these in vitro models of brain development based on innovative methods for three-dimensional stem cell culture might deserve a specific moral status [1, 2]. This would especially be the case if these small stem cell constructs were to develop physiological features of organisms endowed with nervous systems, suggesting that they may be able to feel pain or develop some form of sentience or consciousness. Whether one wants to envision or discard the possibility of conscious brain organoids and whether one wants to acknowledge or dispute its moral relevance, the notion of consciousness is a main pillar of this discussion (even if not the only issue involved [3]). However, consciousness is itself a difficult notion, its nature and definition having been discussed for decades [4, 5]. As a consequence, the ethical debate surrounding brain organoids is deeply entangled with epistemological uncertainty pertaining to the conceptual underpinnings of the science of consciousness and its empirical endeavor.
It has been argued that neuroethics should circumvent this fundamental uncertainty by adhering to a precautionary principle [6]. Even if we do not know with certainty at which point brain organoids could become conscious, following some experimental design principles would ensure that the research does not raise any ethically problematic features in the years to come. It has also been proposed to redirect the inquiry to the “what-kind” issue (rather than the “whether or not” issue) in order to rely on more graspable features for ethical assessment [7]. These strategies, however, make the epistemological issue even more relevant. The question of whether or not current and future organoids can develop a certain form of consciousness (without presupposing what these different forms of consciousness might be) and how to assess this potentiality in existing biological systems is bound to stay with the field of brain organoid technology for a certain time. Even if it is not for advancing ethical issues, there is a theoretical interest in determining the boundary conditions of consciousness and its potential emergence in artificial entities. Although the methodological and knowledge gap is still wide between the research community on cellular biology and stem cell culture on the one side and the research community on consciousness such as cognitive neuroscience on the other, there will be more and more circulation of ideas and methods in the coming years. The results of this scientific endeavor will, in turn, impact ethics.
In this article, I look back at the history of consciousness research to find new perspectives on this contemporary epistemological conundrum. In particular, I suggest the distinction between “global” theories of consciousness and “local” theories of consciousness as a thought-provoking one for those engaged in the difficult task of adapting models of consciousness to the biological reality of brain organoids. The first section introduces the consciousness assessment issue as a general framework and a challenge for any discussion related to the putative consciousness of brain organoids. In the second section, I describe and critically assess the main attempt, so far, at solving the consciousness assessment issue relying on integrated information theory. In the third section, I propose to rely on the distinction between local and global theories of consciousness as a tool to navigate the theoretical landscape, before turning to the analysis of a notable local theory of consciousness, Semir Zeki’s theory of microconsciousness, in the fourth section. I conclude by drawing the epistemological and ethical lessons from this theoretical exploration.
Though not a new technology, new advancements have progressed this field significantly.
People who struggle with facial recognition can find forming relationships a challenge, leading to mental health issues and social anxiety. A new study provides insights into prosopagnosia or face blindness, a condition that impairs facial recognition and affects approximately 1 in 50 people.
The researchers scanned the brains of more than 70 study participants as they watched footage from the popular TV series “Game of Thrones.” Half of the participants were familiar with the show’s famously complex lead characters and the other half had never seen the series.
When lead characters appeared on screen, MRI scans showed that in neurotypical participants who were familiar with the characters, brain activity increased in regions of the brain associated with non-visual knowledge about the characters, such as who they are and what we know about them.
As the world grapples with an aging population, the rise in neurodegenerative diseases such as Alzheimer’s and Parkinson’s is becoming a significant challenge. These conditions place a heavy burden not only on those afflicted but also on their families and society at large. Traditional treatments, including drug therapy and surgery, often come with side effects and high costs, and more critically, they fail to halt the progression of neuronal degeneration or prevent the death of neurons in patients.