Lifeboat Foundation

Year 2022 face_with_colon_three

Mental phenomena influence the material world.

The human mind does not like to make mistakes—and makes time to avoid repeating them. A new study from University of Iowa researchers shows how the human brain, in just one second, can distinguish between an outcome caused by human error and one in which the person is not directly to blame.

Moreover, the researchers found that in cases of human error, the brain takes additional time to catalog the error and inform the rest of the body about it to avoid repeating the mistake.

“The novel aspect about this study is the brain can very quickly distinguish whether an undesirable outcome is due to a (human) error, or due to something else,” says Jan Wessel, professor in the Department of Psychological and Brain Sciences at Iowa and the study’s corresponding author. “If the brain realizes an error was the cause, it will then start additional processes to avoid further errors, which it won’t do if the outcome wasn’t due to its own action.”

Elon Musk’s Neuralink is looking for a volunteer for its first clinical trial of a brain implant chip. The trial, which begins next year, has attracted thousands of prospective patients. The ideal candidate must be an adult under 40 with all four limbs paralyzed. The procedure involves inserting electrodes and wires into the brain, with a small computer replacing part of the skull. The computer will collect and analyze brain activity, sending the data wirelessly to a nearby device. Neuralink aims to translate thoughts into computer commands. However, the company has faced criticism for animal testing practices.

The FDA approved human trials after initially rejecting them in 2022, citing safety concerns.

The FDA had initially rejected the company’s request to run human trials back in 2022, citing safety concerns.

The hope is that people who are unable to speak because of neurological conditions may one day be able to communicate again thanks to this modern technology.

Helping people with motor disorders

“There are many patients who suffer from debilitating motor disorders, like ALS (amyotrophic lateral sclerosis) or locked-in syndrome, that can impair their ability to speak,” said Gregory Cogan, Ph.D., a professor of neurology at Duke University’s School of Medicine and one of the lead researchers involved in the project.

Continue reading “Brain implant turns thoughts into speech with up to 84% accuracy” »

Summary: A new study reveals insights into how general anesthesia affects consciousness and sensory perception.

Using animal models, researchers found that while propofol anesthesia allows sensory information to reach the brain, it disrupts the spread of signals across the cortex. This suggests that consciousness requires synchronized communication throughout the brain, and propofol’s effect of limiting this interconnectivity could explain its role in inducing unconsciousness.

A new map of 56,000 cells in the outer layer of the human brain could inform research into a whole class of diseases.

Thyrotoxicosis was associated with 39% higher risk for cognitive disorders.

Thyrotoxicosis, defined as a low level of serum thyroid-stimulating hormone (TSH), can result from either a primary thyroid disorder (endogenous) or overtreatment of hypothyroidism (exogenous). Evidence suggests that thyrotoxicosis is a risk factor for dementia. In this U.S. longitudinal cohort study, researchers used data from electronic health records for 66,000 people (median age, 68) without low TSH levels or cognitive disorders at baseline and evaluated whether development of thyrotoxicosis was associated with excess risk for cognitive disorders.

During the study period (2014 to 2023), 2,700 patients had low TSH levels (60% exogenous), and 4,800 patients received diagnoses of cognitive disorders. The incidence of cognitive disorders among patients with and without thyrotoxicosis were 11% and 6% at age 75, and 34% and 26% at age 85. Adjusted for multiple variables, all-cause thyrotoxicosis was associated with a significant 39% excess risk for cognitive disorders. Exogenous thyrotoxicosis — and in particular, severe exogenous thyrotoxicosis (TSH 0.1 mIU/L) — were associated most strongly with excess risk for cognitive disorders.

“You can see a very strong modulation, which is always there. As the modulation gets to be more profound, it eventually flattens out, and that’s when the brain reaches the deeper state,” Brown says.

When the amount of drug was reduced, the amplitude of the alpha waves began to increase again.

The researchers also found a distinctive pattern in the slow and delta waves seen in the patients’ EEG readings. Slow and delta oscillations are the slowest brain waves, and as the amount of drug was increased, the frequency of these waves became slower and slower, reflecting a decrease in brain activity.