Lifeboat Foundation

Following your gut. Losing your appetite. A gutsy move. Though we often consider the gut as merely a digestive tool, these common expressions reflect the central role the gut plays in a much wider range of essential functions.

The entire digestive tract is lined by the enteric nervous system (ENS), a vast network of millions of neurons and glial cells—the two primary cell types also found in the central nervous system. While often called the second brain, the ENS not only generates the same neurotransmitters but actually predates the evolution of the central nervous system in the brain.

The functions of the ENS are crucial to life and extend far beyond digestion, as it regulates immunity, gut secretions, and enables complex, bi-directional communication between the gut and the brain. This is why a happy gut co-exists with a happy brain, and why digestive issues can lead to changes in mood and behavior.

Scientists investigating the possible health effects of microplastics have uncovered some disturbing initial results in an experiment based on mice.

When old and young rodents drank microscopic fragments of plastic suspended in their water over the course of three weeks, researchers at the University of Rhode Island found traces of the pollutants had accumulated in every organ of the tiny mammal’s body, including the brain.

The presence of these microplastics was also accompanied by behavioral changes akin to dementia in humans, as well as changes to immune markers in the liver and brain.

HOTs posit a possible way for the brain to render mental states conscious.

We don’t treat Isla’s vision loss as a sad circumstance or as something that is broken in her. It’s so important for us that she knows her vision impairment is not something that makes her less than. If anything, it makes her a stronger, more amazing person, and we couldn’t be prouder of who she is.

Vision impairment is the only symptom she displays of this disease, and we are fighting with everything we have to ensure it stays this way. We were told on diagnosis day that that day was the healthiest Isla would ever be, and that she was at her peak; two years later, and she has continued to defy that, Stockdale added.

The family believes that Isla’s incredible development is a result of the medication, called Miglustat, which she has been taking since November 2022.

Testing time: To see whether the modified VR headset could accurately record brain activity, the researchers had four participants wear it while opening or closing their eyes on command. There is typically an increase in alpha waves in a person’s brain when their eyes are closed, and the researchers could see this increase in the EEG data recorded by their headset.

They also had the participants wear the headset while playing a custom game designed to trigger a type of brain activity that occurs when a person is preparing for an event. As hoped, the researchers were able to see this activity in the recorded EEG data, too.

Looking ahead: The UT Austin team has started filing the paperwork to patent their tech and say they’d be open to working with VR companies to incorporate it into their systems. They don’t say what it costs to make the soft electrodes, so it’s not clear exactly how much consumers or professionals should expect to pay for a modified VR headset.

PHILADELPHIA—Trying to finish your homework while the big game is on TV? “Visual-movement” neurons in the front of your brain can help you stay focused, according to a new study from neuroscientists in the Perelman School of Medicine at the University of Pennsylvania.

In the study, published recently in Neuron, the scientists sought to illuminate the neural mechanism that helps the brain decide whether to focus visual attention on a rewarding task or an alluring distraction. By analyzing neuron activity in animal models as they faced this kind of attentional conflict, the researchers discovered that a pattern of coordinated activity called “beta bursts” in a set of neurons in the lateral prefrontal cortex (LPFC)—a section in the front of the brain responsible for motivation and rewards—appears to have a major role in keeping attention task-focused, essentially by suppressing the influence of the distracting stimulus.

“Our research suggests that while all brains have the ability to focus on a rewarding task and filter out distractions, some are better at it than others,” said senior author Bijan Pesaran PhD, the Robert A Groff II Professor of Neurosurgery at Penn Medicine. “By understanding how our brains process rewarding stimuli, we hope to be able to also understand failures to do so in a variety of cognitive and psychiatric disorders, including attention deficit disorder, schizophrenia, and obsessive-compulsive disorder.”

Every day we encounter circumstances we consider wrong: a starving child, a corrupt politician, an unfaithful partner, a fraudulent scientist. These examples highlight several moral issues, including matters of care, fairness and betrayal. But does anything unite them all?

Philosophers, psychologists and neuroscientists have passionately argued whether moral judgments share something distinctive that separates them from non-moral matters. Moral monists claim that morality is unified by a common characteristic and that all moral issues involve concerns about harm. Pluralists, in contrast, argue that moral judgments are more diverse in nature.

Fascinated by this centuries-old debate, a team of researchers set out to probe the nature of morality using one of moral psychology’s most prolific theories. The group, led by UC Santa Barbara’s René Weber, intensively studied 64 individuals via surveys, interviews and brain imaging on the wrongness of various behaviors.

Similarly, allowing the MyoLegs to flail around for a while in a seemingly aimless fashion gave them better performance with locomotion tasks, as the researchers described in another paper presented at the recent Robotics Science and Systems meeting. Vittorio Caggiano, a Meta researcher on the project who has a background in both AI and neuroscience, says that scientists in the fields of neuroscience and biomechanics are learning from the MyoSuite work. “This fundamental knowledge [of how motor control works] is very generalizable to other systems,” he says. “Once they understand the fundamental mechanics, then they can apply those principles to other areas.”

This year, MyoChallenge 2023 (which will also culminate at the NeurIPS meeting in December) requires teams to use the MyoArm to pick up, manipulate, and accurately place common household objects and to use the MyoLegs to either pursue or evade an opponent in a game of tag.

Emo Todorov, an associate professor of computer science and engineering at the University of Washington, has worked on similar biomechanical models as part of the popular Mujoco physics simulator. (Todorov was not involved with the current Meta research but did oversee Kumar’s doctoral work some years back.) He says that MyoSuite’s focus on learning general representations means that control strategies can be useful for “a whole family of tasks.” He notes that their generalized control strategies are analogous to the neuroscience principle of muscle synergies, in which the nervous system activates groups of muscles at once to build up to larger gestures, thus reducing the computational burden of movement. “MyoSuite is able to construct such representations from first principles,” Todorov says.

Cells hidden in the skull may point to a way to detect, diagnose and treat inflamed brains.

A detailed look at the skull reveals that bone marrow cells there change and are recruited to the brain after injury, possibly traveling through tiny channels connecting the skull and the outer protective layer of the brain. Paired with the discovery that inflammation in the skull is disease-specific, these new findings collectively suggest the skull’s marrow could serve as a target to track and potentially treat neurological disorders involving brain inflammation, researchers report August 9 in Cell.

New observations of skull cell signals and skull tunnels suggest bone marrow there could be used to monitor neurological diseases.