Lifeboat Foundation

Cancer is a deadly disease with multiple risk factors. Risk factors are dependent on the type of cancer and each one is treated differently. The heterogeneity of various cancers is the main reason there is no cure. Additionally, cancer evolves and can also come back after being treated and lying dormant for years. Therefore, it is very difficult to find an effective treatment that provides high quality of life for patients.

One aggressive cancer that is difficult to treat includes glioblastoma. This brain tumor is fast-growing and results in the form of many different symptoms including headache, vomiting, and seizures. Unfortunately, there is not much known on glioblastoma. The cause of this disease is unclear and treatment options are limited. This tumor stays in the brain and does not metastasize, but because of its location, glioblastoma is hard to treat. Currently, treatment options include radiation, chemotherapy, and surgery with limited success. Even immunotherapy, a more recent treatment, which activates the body’s immune system to kill the tumor has limited efficacy in the brain.

A group of researchers led by Dr. Robert Prins at the David Geffen School of Medicine at University of California Los Angeles (UCLA) recently published an article in the Journal of Clinical Investigation (JCI) describing new research that could help overcome obstacles to glioblastoma treatment. More specifically, Prins and colleagues have reported why glioblastoma that originates from other parts of the body respond better to immunotherapy compared to glioblastoma that originates in the brain.

Sights and sounds are easily digitized, but scents have eluded researchers until now.

This week in neuroscience, we’ve seen groundbreaking advancements ranging from a diet that can potentially extend lifespan without calorie restriction, to a new drug that could revolutionize obesity treatment.

A study of a genetic mouse model of schizophrenia supports two long-debated hypotheses, and unveils additional new clues about the biological roots of the disorder.

Abnormal levels of stress hormones such as adrenaline and cortisol are linked to a variety of mental health disorders, including depression and posttraumatic stress disorder (PTSD).

MIT researchers have now devised a way to remotely control the release of these hormones from the adrenal gland, using magnetic nanoparticles. This approach could help scientists to learn more about how hormone release influences mental health, and could eventually offer a new way to treat hormone-linked disorders, the researchers say.

Scientists from the University of Sydney and Fudan University have found human brain signals traveling across the outer layer of neural tissue that naturally arrange themselves to resemble swirling spirals.

Published in the journal Nature Human Behaviour, the study suggests that these widespread spiral patterns, seen during both rest and cognitive activity, play a role in organizing brain function and cognitive processes.

Senior author Associate Professor Pulin Gong, from the School of Physics in the Faculty of Science, said the discovery could have the potential to advance powerful computing machines inspired by the intricate workings of the human brain.

A new study reveals the brain circuit that controls sex drive in male mice. Scientists believe this finding could apply to humans and may allow them to manipulate the male libido.

Scientists at Stanford Medicine have identified the exact part of the brain that controls sex drive in mice. It is possible that the same part of the human brain also regulates libido in men.

“We’ve singled out a circuit in male mammals’ brains that controls sexual recognition, libido, and mating behavior and pleasure,” said Nirao Shah, one of the senior researchers and a professor of behavioral sciences at Stanford.

After a certain age, approximately 40% of people experience some degree of hearing loss. While age-related hearing loss is most prevalent in adults over the age of 65, it can start occurring far earlier than that, when people are in their 40s or 50s.

Despite their widespread use, existing diagnostic techniques might be unable to detect earlier signs of hearing loss, such as the loss of the ability to hear speech in crowded or noisy environments. Some researchers have thus been trying to devise viable techniques to detect subtler forms of hearing loss, so that they can be addressed early, before they are irreparable.

To this end, two neuroscientists at the Rotman Research Institute in Canada have recently been exploring the relationship between effortful listening and eye movements. Their most recent paper, published in The Journal of Neuroscience, suggests eye movements tend to decrease while young adults are placing greater effort in trying to hear speech.

Walking is a complex mechanism involving both automatic processes and conscious control. Its dysfunction can have multiple, sometimes extremely subtle causes, within the motor cortex, brain stem, spinal cord, or muscles. At Paris Brain Institute, Martin Carbo-Tano, Mathilde Lapoix, and their colleagues in the “Spinal Sensory Signaling” team, led by Claire Wyart (Inserm), have focused on a specific component of locomotion: forward propulsion.

In a study published in Nature Neuroscience, they show that it involves a region classically called the mesencephalic locomotor region, which controls the vigor and speed of movement and transmits the nervous message to the spinal cord via control neurons located in the brainstem.

This new mapping carried out in zebrafish corroborates recent studies in mice. It could eventually be extended to humans—helping to understand how movement control circuits can malfunction, in Parkinson’s disease notably.